Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kathleen J Dumas"'
Autor:
Annabel A Ferguson, Sudipa Roy, Kaitlyn N Kormanik, Yongsoon Kim, Kathleen J Dumas, Vladimir B Ritov, Dietrich Matern, Patrick J Hu, Alfred L Fisher
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004020 (2013)
Recent work has identified changes in the metabolism of the aromatic amino acid tyrosine as a risk factor for diabetes and a contributor to the development of liver cancer. While these findings could suggest a role for tyrosine as a direct regulator
Externí odkaz:
https://doaj.org/article/e80bd8e6faa045ac90bf2098b2e3ed86
Autor:
Theodore W. Peters, Christopher S. Nelson, Akos A. Gerencser, Kathleen J. Dumas, Brandon Tavshanjian, Kyu Chul Chang, Gordon J. Lithgow, Robert E. Hughes
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify t
Externí odkaz:
https://doaj.org/article/21cf586f07fa4cc2bb6f00f7365e300d
Autor:
Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face
Externí odkaz:
https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
Autor:
Omar A. Itani, Stephane Flibotte, Kathleen J. Dumas, Chunfang Guo, Thomas Blumenthal, Patrick J. Hu
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1751-1756 (2016)
Metazoan introns contain a polypyrimidine tract immediately upstream of the AG dinucleotide that defines the 3′ splice site. In the nematode Caenorhabditis elegans, 3′ splice sites are characterized by a highly conserved UUUUCAG/R octamer motif.
Externí odkaz:
https://doaj.org/article/8937a89a33f04a399466d440e6a8784b
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 351-356 (2016)
Chromoanasynthesis is a recently discovered phenomenon in humans with congenital diseases that is characterized by complex genomic rearrangements (CGRs) resulting from aberrant repair of catastrophic chromosomal damage. How these CGRs are induced is
Externí odkaz:
https://doaj.org/article/e7f65930a3a24e34a461e8d58ccfe7fa
Autor:
Kyu Chul Chang, Akos A. Gerencser, Robert E. Hughes, Kathleen J. Dumas, Brandon Tavshanjian, Gordon J. Lithgow, Theodore W. Peters, Christopher S. Nelson
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
G3: Genes, Genomes, Genetics, Vol 8, Iss 11, Pp 3421-3431 (2018)
A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b248d7bc8c3bbf3f8d8abef225e2b5ec
http://europepmc.org/articles/PMC6222566
http://europepmc.org/articles/PMC6222566
Autor:
Xin Li, Jing Yang, Kathleen J. Dumas, Ling Qi, Peter Arvan, Leena Haataja, Hung-Jen Shih, Patrick J. Hu, Stephane Flibotte, Colin Delaney, Jeeyeon Cha, Jialu Xu, Omar A. Itani, Ming Liu
Publikováno v:
Science Advances
A forward genetic screen in C. elegans leads to the discovery of a role for a conserved ER membrane protein in insulin biogenesis.
The mechanistic basis for the biogenesis of peptide hormones and growth factors is poorly understood. Here, we sho
The mechanistic basis for the biogenesis of peptide hormones and growth factors is poorly understood. Here, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587779b66a88ea6640d8c044f5301d87
http://europepmc.org/articles/PMC6892615
http://europepmc.org/articles/PMC6892615
Autor:
Sonnet S. Davis, Dylan J. Sorensen, Gordon J. Lithgow, Karla A. Mark, Birgit Schilling, Tal Ronnen Oron, Mark Lucanic, Kathleen J. Dumas, Arvind Ramanathan, Rachel B. Brem, Simon Melov, Dipa Bhaumik, Bradford W. Gibson
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1227-1237 (2016)
Summary: Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca66f986cfc7ddfd5a47ee887eb7250
Autor:
Chunfang Guo, Thomas Blumenthal, Omar A. Itani, Stephane Flibotte, Patrick J. Hu, Kathleen J. Dumas
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1751-1756 (2016)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Metazoan introns contain a polypyrimidine tract immediately upstream of the AG dinucleotide that defines the 3′ splice site. In the nematode Caenorhabditis elegans, 3′ splice sites are characterized by a highly conserved UUUUCAG/R octamer motif.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d163a11694654c0420bcc2ef89c1e2bc
http://g3journal.org/lookup/doi/10.1534/g3.116.028662
http://g3journal.org/lookup/doi/10.1534/g3.116.028662
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 351-356 (2016)
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 351-356 (2016)
Chromoanasynthesis is a recently discovered phenomenon in humans with congenital diseases that is characterized by complex genomic rearrangements (CGRs) resulting from aberrant repair of catastrophic chromosomal damage. How these CGRs are induced is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd29f5f47fc0033c45043328502d87dd
http://europepmc.org/articles/PMC4751554
http://europepmc.org/articles/PMC4751554