Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kathleen I. MacKenzie"'
Autor:
Mary Jo Numerick, Kathleen I. MacKenzie, Bryan Goodwin, Guizhen Luo, Jane G Binz, Yaping Liu, Bhasha Desai, Steven A. Kliewer, Stacey A. Jones, Traci Ann Mansfield, Steve Dennis
Publikováno v:
Journal of Clinical Investigation. 112:1678-1687
Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver,
Autor:
Bryan Goodwin, Kathleen K. Brown, Yaping Liu, John F. Reinhard, Diane Hawkins-Brown, Stacey A. Jones, Curtis D. Klaassen, Jeff L. Staudinger, Kathleen I. MacKenzie, Anne M. Latour, Timothy M. Willson, Beverly H. Koller, Steven A. Kliewer
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3369-3374
The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which induce cytochrome P450 3A ( CYP3A ) expression and protect the body from harmful chemicals. In this study, we demonstrate