Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes

Autor: Fang Xie, Federica Franciosi, Hakan Cakmak, Jing Chen, Marco Conti, Simona Torcia, Chih-Jen Lin, Courtney Onodera, Kathleen Horner, Marcelle I. Cedars, Miguel Ramalho-Santos, Jun S. Song

Publikováno v: Nature Cell Biology. 15:1415-1423

Germ cells divide and differentiate in a unique local microenvironment under the control of somatic cells. Signals released in this niche instruct oocyte reentry into the meiotic cell cycle. Once initiated, the progression through meiosis and the ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcc518491eedc4030fc19a308290765
https://doi.org/10.1038/ncb2873

Luteinizing Hormone-Dependent Activation of the Epidermal Growth Factor Network Is Essential for Ovulation

Autor: Minnie Hsieh, Daekee Lee, David W. Threadgill, Sara Panigone, David C. Lee, Alekos A. Theologis, Marco Conti, Ruby Chen, Kathleen Horner

Publikováno v: Molecular and Cellular Biology. 27:1914-1924

In the preovulatory ovarian follicle, mammalian oocytes are maintained in prophase meiotic arrest until the luteinizing hormone (LH) surge induces reentry into the first meiotic division. Dramatic changes in the somatic cells surrounding the oocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f364a7b9b36a71d0b7bad9161b39b300
https://doi.org/10.1128/mcb.01919-06

Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility

Autor: Catherine Jin, Marco Conti, Vincent C. Manganiello, Mary D Hinckley, Steven Hockman, Chengyu Liu, Sunhee Park, Taku Nedachi, Kathleen Horner, Silvia Masciarelli

Publikováno v: Journal of Clinical Investigation. 114:196-205

Since cAMP blocks meiotic maturation of mammalian and amphibian oocytes in vitro and cyclic nucleotide phosphodiesterase 3A (PDE3A) is primarily responsible for oocyte cAMP hydrolysis, we generated PDE3A-deficient mice by homologous recombination. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40049aeac31585d54ce0ac2a9033358
https://doi.org/10.1172/jci21804

Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

Autor: Peter Day, Andrew J. Patterson, Rani Agrawal, Ping Wang, Sébastien Granier, Tao Lei, Marco Conti, Matthew D. Bruss, Yvonne L Wang, Kathleen Horner, Brian K. Kobilka, Søren G. F. Rasmussen, Wito Richter

Publikováno v: The EMBO Journal

Beta1- and beta2-adrenergic receptors (betaARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by beta1AR but not beta2AR signaling, and chroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3711a3f4b055d249a9af5504c0235e5
https://pubmed.ncbi.nlm.nih.gov/18188154

Functional localization of cAMP signalling in cardiac myocytes

Autor: RODOLPHE FISCHMEISTER, Francesca Rochais, Grégoire Vandecasteele, Aniella Abi-Gerges, Florence Lefebvre, Dermot Cooper, Kathleen Horner, Marco Conti

Publikováno v: Biochemical Society Focussed meeting on compartmentalization in cAMP signalling
Biochemical Society Focussed meeting on compartmentalization in cAMP signalling, 2006, Cambridge, France
HAL

Compartmentation of cAMP is thought to generate the specificity of Gs-coupled receptors action in cardiac myocytes, with phosphodiesterases (PDEs) playing a major role in this process by preventing cAMP diffusion. We have tested this hypothesis in ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::420cc715bb8ae4009e3d7b99ce2f40fb
https://www.hal.inserm.fr/inserm-00000012