Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kathleen H. Mortell"'
Autor:
Brenda Martino, Diana L. Donnelly-Roberts, Jill M. Wetter, Marie E. Uchic, Kennan C. Marsh, Ahmed A. Hakeem, Sherry Nelson, Teodozyj Kolasa, Gin C. Hsieh, Odile F. El-Kouhen, Kathleen H. Mortell, Rohde Jeffrey J, Meena V. Patel, Ruth L. Martin, Marlon D. Cowart, Peter R. Hollingsworth, Marc A. Terranova, Andrew O. Stewart, Robert B. Moreland, and Jorge D. Brioni, Mark A. Matulenko, Loan N. Miller, Gary A. Gintant, James P. Sullivan, Marian T. Namovic, John F. Darbyshire, Renjie Chang, Masaki Nakane
Publikováno v:
Journal of Medicinal Chemistry. 49:7450-7465
The goal of this study was to identify a structurally distinct D(4)-selective agonist with superior oral bioavailability to our first-generation clinical candidate 1a (ABT-724) for the potential treatment of erectile dysfunction. Arylpiperazines such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f481cffca5c5c281238800552907e71e
https://doi.org/10.1021/jm060662k
https://doi.org/10.1021/jm060662k
Autor:
Carrie L. Wade, James J. Lynch, Hongyu Xu, Kennan C. Marsh, Chengmin Zhong, Kathleen H. Mortell, Chih Hung Lee, Michael F. Jarvis, Chang Z. Zhu, William H. Bunnelle, David J. Anderson, Murali Gopalakrishnan, Prisca Honore
Publikováno v:
Pain. 125:136-142
Gabapentin and pregabalin have been demonstrated, both in animal pain models and clinically, to be effective analgesics particularly for the treatment of neuropathic pain. The precise mechanism of action for these two drugs is unknown, but they are g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba60e77cd12767e06e4ff8be1eb38c4
https://doi.org/10.1016/j.pain.2006.05.012
https://doi.org/10.1016/j.pain.2006.05.012
Autor:
James J. Lynch, Heath A. McDonald, Kathy Sarris, Michael F. Jarvis, Murali Gopalakrishnan, David J. Anderson, Chih-Hung Lee, Sherry Nelson, Kathleen H. Mortell, Prisca Honore, Scott J. Baker, Reza S. Sabet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1138-1141
A series of α-amino acids were identified as ligands which compete with gabapentin for binding to the α 2 δ subunit of voltage-dependent Ca 2+ channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1316212f41d4171ca0d5993172aa1f4b
https://doi.org/10.1016/j.bmcl.2005.11.108
https://doi.org/10.1016/j.bmcl.2005.11.108
Publikováno v:
Journal of Molecular Catalysis A: Chemical. 116:209-216
Non-natural carbohydrate-bearing polymers are emerging as important materials for the investigation of multivalent carbohydrate-protein interactions. In the present study, neoglycopolymers were generated via aqueous ring-opening metathesis polymeriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0a59f5efeb58e83850cfff366ca7f1b
https://doi.org/10.1016/s1381-1169(96)00194-x
https://doi.org/10.1016/s1381-1169(96)00194-x
Autor:
Mary C. Chervenak, Kathleen H. Mortell, Laura L. Kiessling, Eric J. Toone, Ross V. Weatherman
Publikováno v:
Biochemistry. 35:3619-3624
The binding of the mannose/glucose specific lectins from Canavalia ensiformis (concanavalin A) and Dioclea grandiflora to a series of C-glucosides were studied by titration microcalorimetry and fluorescence anisotropy titration. These closely related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e6de2aba042bd9a2bd449faa1151ba
https://doi.org/10.1021/bi951916z
https://doi.org/10.1021/bi951916z
Autor:
Jens Halvard Grønlien, Kathleen H. Mortell, Kirsten Thorin Hagene, Murali Gopalakrishnan, William H. Bunnelle, David J. Anderson, Michael R. Schrimpf
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
A series of alpha7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three series of compounds in which aryl moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fec1f21ad27ef311874b6bfbaff3f6a
https://pubmed.ncbi.nlm.nih.gov/19954975
https://pubmed.ncbi.nlm.nih.gov/19954975
Publikováno v:
Glycoscience ISBN: 9783540361541
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6386aeef3819c0d036331300f519819
https://doi.org/10.1007/978-3-540-30429-6_64
https://doi.org/10.1007/978-3-540-30429-6_64
Autor:
Kathleen H, Mortell, David J, Anderson, James J, Lynch, Sherry L, Nelson, Kathy, Sarris, Heath, McDonald, Reza, Sabet, Scott, Baker, Prisca, Honore, Chih-Hung, Lee, Michael F, Jarvis, Murali, Gopalakrishnan
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c38cfc851c2e0ef07f554fb7434f4f2
https://pubmed.ncbi.nlm.nih.gov/16380257
https://pubmed.ncbi.nlm.nih.gov/16380257
Publikováno v:
Glycoscience ISBN: 9783662118955
Glycoscience: Chemistry and Chemical Biology I–III ISBN: 9783540677642
Glycoscience: Chemistry and Chemical Biology I–III ISBN: 9783540677642
Protein-carbohydrate recognition events mediate numerous physiological processes including fertilization, pathogen-cell adhesion, and the inflammatory response [1, 2, 3, 4]. Given the specificity of these biological recognition events, it is surprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecd901ca0068c71eb12024794a2c692
https://doi.org/10.1007/978-3-662-11893-1_18
https://doi.org/10.1007/978-3-662-11893-1_18
Autor:
Clark A. Briggs, Kathleen H. Mortell, Jens Halvard Grønlien, Hilde Ween, Rachid El-Kouhen, Chih-Hung Lee, Karla Drescher, Murali Gopalakrishnan, John Malysz, Kristen Thorin-Hagene, David J. Anderson
Publikováno v:
Biochemical Pharmacology. 82:1030
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab3921a197865471b13d6df2ba1fb285
https://doi.org/10.1016/j.bcp.2011.07.022
https://doi.org/10.1016/j.bcp.2011.07.022