Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kathleen G Mountjoy"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140320 (2015)
MRAP1 but not MRAP2, is essential for melanocortin receptor 2 functional expression. Human MRAP1 splice variant (hMRAPα) and human MRAP2 (hMRAP2) also interact with the other melanocortin receptor subtypes in vitro, although the physiological signif
Externí odkaz:
https://doaj.org/article/d9287c8bd7a54329acaa544ca75c0c9e
Autor:
Jarl E. S. Wikberg, Jeffrey B. Tatro, Helgi Schiöth, Colin Pouton, Kathleen G. Mountjoy, Victor J. Hruby, Carrie Haskell-Luevano, Ira Gantz, Tung M. Fong, Sadaf Farooqi, Alex N. Eberle, Roger D. Cone, Adrian J. L. Clark, Biao-Xin Chai, Vanni Caruso
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e1dd58e2809f3d3ee0d5953002ec11
https://doi.org/10.2218/gtopdb/f38/2023.1
https://doi.org/10.2218/gtopdb/f38/2023.1
Autor:
Nathaniel A. K. Glenn, David B. Finlay, Emma R. Carruthers, Kathleen G. Mountjoy, Christopher S. Walker, Natasha L. Grimsey
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23a448d5ff1378e9bde6bc17cb980f5
https://doi.org/10.1111/bph.16095
https://doi.org/10.1111/bph.16095
Publikováno v:
Journal of Molecular Endocrinology
The melanocortin-4 receptor (MC4R), a critical G-protein-coupled receptor (GPCR) regulating energy homeostasis, activates multiple signalling pathways, including mobilisation of intracellular calcium ([Ca2+]i). However, very little is known about the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37467c2aded8e6346be13a32d0f0f0a5
https://doi.org/10.1530/jme-20-0285
https://doi.org/10.1530/jme-20-0285
Autor:
Kathleen G. Mountjoy
Publikováno v:
Journal of Immunoassay and Immunochemistry. 42:154-173
Enzyme-linked immunosorbent assay (ELISA) has long been the standard for quantitative analysis of metabolic hormones and cytokines. LUMINEX multiplex bead array assays were developed as cost- and time-effective alternatives to ELISA, but they are the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f23bea14641d397b9ec85c45f70648
https://doi.org/10.1080/15321819.2020.1838924
https://doi.org/10.1080/15321819.2020.1838924
Autor:
Helgi B. Schiöth, Alex N. Eberle, Sadaf Farooqi, Biaoxin Chai, Roger D. Cone, Colin W. Pouton, Jeffrey B. Tatro, Vanni Caruso, Jarl E. S. Wikberg, Adrian J. L. Clark, Tung M. Fong, Carrie Haskell-Luevano, Victor J. Hruby, Kathleen G. Mountjoy, Ira Gantz
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH). Endogenous anta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2ace4b81cb4715932d98c70bb99013
https://doi.org/10.2218/gtopdb/f38/2021.3
https://doi.org/10.2218/gtopdb/f38/2021.3
Publikováno v:
Endocrinology
Mice with a targeted mutation in the pro-opiomelanocortin (Pomc) gene (Pomctm1/tm1 mice) are unable to synthesize desacetyl-α-MSH and α-MSH and they develop obesity when fed chow diet. In this study, we hypothesized that a chronic high-fat (HF) die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5c30881b2e8ebdeaec5da6427cfe3f
https://doi.org/10.1210/en.2018-00924
https://doi.org/10.1210/en.2018-00924
Publikováno v:
Journal of the Endocrine Society
The human melanocortin 4 receptor (hMC4R) plays a critical role in the regulation of energy balance with more than 150 distinct human obesity-associated mutations. Most exhibit defective MC4R functionality but six have been reported to associate with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13e0b9c4c972cadd5eef681ebaf4e41
http://europepmc.org/articles/PMC7207459
http://europepmc.org/articles/PMC7207459
Publikováno v:
Biochimica et biophysica acta. General subjects. 1864(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd3e8f9beeb37fe7aa5651e4462c8960
https://pubmed.ncbi.nlm.nih.gov/32585252
https://pubmed.ncbi.nlm.nih.gov/32585252
Autor:
Kathleen G. Mountjoy, Shree S Kumar
Publikováno v:
Journal of the Endocrine Society
There is compelling evidence for human melanocortin-4-receptor (hMC4R) playing a critical function regulating energy balance; yet signal transduction pathways contributing to this are unclear. The hMC4R activates multiple signaling pathways, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3566df56fa5a1b72780c1a7620f17f66
http://europepmc.org/articles/PMC8089185
http://europepmc.org/articles/PMC8089185