Výsledky vyhledávání - "Kathleen F. Ludwig"

Supplementary Figures from Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Autor: Rolf A. Brekken, James B. Lorens, Anirban Maitra, N.V. Rajeshkumar, Shinichi Yabuuchi, Victoria H. Cruz, Jason E. Toombs, Mary Topalovski, Katarzyna Wnuk-Lipinska, Noah B. Sorrelle, Wenting Du, Kathleen F. Ludwig

Supplementary Figures 1-7 and Supplementary Table 1. Supplementary Figure 1 H&E stain and trichrome stain of representative 7-week-old KIC tumor tissue. Supplementary Figure 2 Axl gene expression in pancreatic cancer patient-derived xenografts. Suppl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318dd776a2f705e23be8ac011adcc930
https://doi.org/10.1158/0008-5472.22417191

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Supplementary Methods from Small-Molecule Inhibition of Axl Targets Tumor Immune Suppression and Enhances Chemotherapy in Pancreatic Cancer

Expanded Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35447ae3039f835ba31b710398913978
https://doi.org/10.1158/0008-5472.22417188.v1

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Supplementary Tables S1-S2 from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Autor: Rolf A. Brekken, James B. Lorens, Michael T. Dellinger, David Micklem, Sean P. Dineen, Miao Wang, Jason E. Toombs, Renate Ranaweera, Tone Sandal, Gry Haaland, Noah Sorrelle, Kathleen F. Ludwig, Amanda Kirane

Supplementary Tables S1-S2. Metastatic events in preclinical models of PDA (S1); Warfarin enhances the activity of gemcitabine in an Axl-dependent manner (S2).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f51f7f62631108f61ea5f307de4091
https://doi.org/10.1158/0008-5472.22405361.v1

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Supplementary Figures S1-S6 from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Supplementary Figures S1-S6. Axl is required for the growth of Mia PaCa-2 tumors (S1); Characterization of 10C9 (S2); Warfarin inhibits autocrine activation of Axl in pancreatic tumor cells (S3); In vivo warfarin effects (S4); Maintenance of mesenchy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3811e238c2eb5002e9c3bdaf3e2302ed
https://doi.org/10.1158/0008-5472.22405367

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Data from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Repurposing “old” drugs can facilitate rapid clinical translation but necessitates novel mechanistic insight. Warfarin, a vitamin K “antagonist” used clinically for the prevention of thrombosis for more than 50 years, has been shown to have a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d564c7a77f2cd47e20a363fe4fd21ed
https://doi.org/10.1158/0008-5472.c.6506816

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Supplementary Methods and References from Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a11e569036be7761c940f3d5140a0c7
https://doi.org/10.1158/0008-5472.22405364.v1

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