Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Kathleen E. Mcgrath"'
Autor:
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression
Externí odkaz:
https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
Autor:
Yu-Shan Huang, Luis F. Delgadillo, Kathryn H. Cyr, Paul D. Kingsley, Xiuli An, Kathleen E. McGrath, Narla Mohandas, John G. Conboy, Richard E. Waugh, Jiandi Wan, James Palis
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane skeleton, composed of spectrin, 4.1R-complex, and ankyr
Externí odkaz:
https://doaj.org/article/59ae1bf1686e4ba7bff3a96a98431c78
Autor:
Ah Ram Kim, Jayme L. Olsen, Samantha J. England, Yu-Shan Huang, Katherine H. Fegan, Luis F. Delgadillo, Kathleen E. McGrath, Paul D. Kingsley, Richard E. Waugh, James Palis
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 995-1003 (2015)
Red blood cells (RBCs), responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to meet the increased demand for RBC transfusions projected to occur as our population ages. We
Externí odkaz:
https://doaj.org/article/3ae0fc0361fe4cda8fa7712907e42bec
Autor:
Kathleen E. McGrath, Jenna M. Frame, Katherine H. Fegan, James R. Bowen, Simon J. Conway, Seana C. Catherman, Paul D. Kingsley, Anne D. Koniski, James Palis
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1892-1904 (2015)
Hematopoietic potential arises in mammalian embryos before adult-repopulating hematopoietic stem cells (HSCs). At embryonic day 9.5 (E9.5), we show the first murine definitive erythro-myeloid progenitors (EMPs) have an immunophenotype distinct from p
Externí odkaz:
https://doaj.org/article/269ef6228cb94fd289fb02d1e72d7407
Autor:
Preeti Maurya, Sara K. Ture, Chen Li, Kristin M. Scheible, Kathleen E. McGrath, James Palis, Craig N. Morrell
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:873-885
Background: Thrombocytopenia is common in preterm neonates. Platelet transfusions are sometimes given to thrombocytopenic neonates with the hope of reducing the bleeding risk, however, there are little clinical data to support this practice, and plat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a509dd32c713372f9b4c26632714684
https://doi.org/10.1161/atvbaha.122.318162
https://doi.org/10.1161/atvbaha.122.318162
Autor:
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Ji-Ying Song, Cor Lieftink, Matilda Ayidah, Colin E. J. Pritchard, Judith Vivié, Kathleen E. Mcgrath, Ivo J. Huijbers, Sjaak Philipsen, Marieke von Lindern, Wilbert Zwart, Roderick L. Beijersbergen, James Palis, Paul C. M. van den Berk, Heinz Jacobs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(4):e2216055120. National Academy of Sciences
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e077fb0f8ba8a59c4009b6aa84c1c
https://pure.eur.nl/en/publications/97d9e55e-3739-4a7c-9feb-61f4e8e1c6a8
https://pure.eur.nl/en/publications/97d9e55e-3739-4a7c-9feb-61f4e8e1c6a8
Autor:
Noah Salama, Olivia Lynch, Emily R Quarato, Yuko Kawano, Benjamin Rodems, Eric Cefaloni, Tzu-Chieh Ho, Kathleen E. McGrath, Michael W. Becker, Jane L. Liesveld, Paula M Vertino, James Palis, Jeevisha Bajaj, Laura M. Calvi
Publikováno v:
Blood. 140:9757-9758
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661d97e24a591dde2f123251b46b731c
https://doi.org/10.1182/blood-2022-168015
https://doi.org/10.1182/blood-2022-168015
Autor:
Michael H. Atkins, Rebecca Scarfò, Kathleen E. McGrath, Donghe Yang, James Palis, Andrea Ditadi, Gordon M. Keller
Publikováno v:
Journal of Experimental Medicine. 219
In the mouse, the first hematopoietic cells are generated in the yolk sac from the primitive, erythro-myeloid progenitor (EMP) and lymphoid programs that are specified before the emergence of hematopoietic stem cells. While many of the yolk sac–der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2a6f0bfe3e99207e6a4fb665c50b84
https://doi.org/10.1084/jem.20211924
https://doi.org/10.1084/jem.20211924
Autor:
Jayme L. Olsen, Kathleen E. McGrath, Kristin Murphy, Taylor Schofield, Michael Getman, Mohandas Narla, Lionel Blanc, Vincent P Schulz, Patrick G. Gallagher, Laurie A. Steiner, James Palis
Publikováno v:
Blood. 140:8152-8152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49457c4973a4b1bd6bcd5119e2e037f
https://doi.org/10.1182/blood-2022-167830
https://doi.org/10.1182/blood-2022-167830
Autor:
Travis Nemkov, Paul D. Kingsley, Monika Dzieciatkowska, Jeffrey Malik, Kathleen E. McGrath, Kirk C. Hansen, Angelo D’Alessandro, James Palis
Publikováno v:
Blood advances. 6(10)
Primitive erythropoiesis is a critical component of the fetal cardiovascular network and is essential for the growth and survival of the mammalian embryo. The need to rapidly establish a functional cardiovascular system is met, in part, by the intrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd3b28756676bb2deb161104420c123
https://pubmed.ncbi.nlm.nih.gov/35139174
https://pubmed.ncbi.nlm.nih.gov/35139174