Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kathleen E. McGinness"'
Autor:
Taylor L Hickman, Eugene Choi, Kathleen R Whiteman, Sujatha Muralidharan, Tapasya Pai, Tyler Johnson, Avani Parikh, Taylor Friedman, Madaline Gilbert, Binzhang Shen, Luke Barron, Kathleen E McGinness, Seth A Ettenberg, Greg T Motz, Glen J Weiss, Amy Jensen-Smith
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0266980 (2022)
PurposeThe solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can impr
Externí odkaz:
https://doaj.org/article/e9bfd0d7932a41a6b4376dcb7b3a2440
Autor:
Tyler B. Johnson, Taylor Friedman, Eugene Choi, Madaline Gilbert, Barron Luke, Sujatha Muralidharan, Tapasya Pai, Kathleen E. McGinness, Taylor Hickman, Seth Ettenberg, Amy Jensen-Smith, Kathleen R. Whiteman, Binzhang Shen, Greg Motz, Avani Parikh, Glen J. Weiss
PurposeThe solid tumor microenvironment (TME) drives T cell dysfunction and inhibits the effectiveness of immunotherapies such as chimeric antigen receptor-based T cell (CAR T) cells. Early data has shown that modulation of T cell metabolism can impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdc6eb317e873444c9c4a90e0f6bd32d
https://doi.org/10.1101/2021.11.17.469041
https://doi.org/10.1101/2021.11.17.469041
Autor:
Greg Motz, Veronika Bachanova, Patricia L. Harris, Luke P. Akard, Kathleen E. McGinness, Jonathon B. Cohen, Jessica Sachs, Ann Ranger, Ian W. Flinn, Samantha Jaglowski
Publikováno v:
Cancer Immunology Research. 7:A003-A003
Background: Autologous T cells engineered to express a universal ACTR chimeric receptor kill tumors through interactions with tumor-targeting antibodies [Kudo, Cancer Res 2014]. ACTR707 was identified through rigorous preclinical screening of more th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16183dfb571424199e6620e24b0795c
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a003
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a003
Autor:
Leonid A. Parunov, Kathleen E. McGinness, Mikhail A. Panteleev, Natalia P. Soshitova, Fazoil I. Ataullakhanov, Konstantin G. Kopylov, James C. Gilbert, Robert G. Schaub, Maria A. Kumskova, Anna N. Balandina, Olga A. Fadeeva
Publikováno v:
Journal of Thrombosis and Haemostasis. 9:1825-1834
Summary. Background: Tissue factor pathway inhibitor (TFPI) is a major regulator of clotting initiation and a promising target for pro- and anticoagulation therapy. The aptamer BAX499 (formerly ARC19499) is a high-affinity specific TFPI antagonist de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8cc8cdda05705fac5a0de77dd1576e
https://doi.org/10.1111/j.1538-7836.2011.04412.x
https://doi.org/10.1111/j.1538-7836.2011.04412.x
Autor:
Heather Huet, Tapasya Pai, James Hemphill, Greg Motz, Casey Judge, Kathleen E. McGinness, Ann Ranger, Michael J. Vasconcelles, John H. Shin, Anthony Barnitz, James Kim, Seth Ettenberg, Kathleen R. Whiteman, Geoffrey Hodge, Birgit Schultes
Publikováno v:
Molecular Cancer Therapeutics. 17:B105-B105
The Antibody-Coupled T-cell Receptor (ACTR) platform is an autologous engineered T-cell therapy developed to combine with tumor-targeting antibodies to exert potent antitumor immune responses and tumor cell killing. The ACTR construct is composed of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ead0fa17e9f5ea4d7a8f02a17341f8e
https://doi.org/10.1158/1535-7163.targ-17-b105
https://doi.org/10.1158/1535-7163.targ-17-b105
Publikováno v:
Chemistry & Biology. 9(5):585-596
Variants of the class I ligase ribozyme, which catalyzes joining of the 3' end of a template bound oligonucleotide to its own 5' end, have been made to evolve in a continuous manner by a simple serial transfer procedure that can be carried out indefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8860a42416c1c1255b738935c2d670
Autor:
Kathleen E. McGinness, Gerald F. Joyce
Publikováno v:
Journal of Biological Chemistry. 277:2987-2991
A systematic analysis was carried out to examine the effects of ribonucleotide substitution at various locations within the promoter element for T7 RNA polymerase. Ribonucleotides could be introduced at most positions without significantly decreasing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861f03cc877c9eaa4480957b024266e5
https://doi.org/10.1074/jbc.m108820200
https://doi.org/10.1074/jbc.m108820200
Autor:
Birgit Schultes, Seth Ettenberg, Shyra Gardai, Lori Westendorf, Katie O'Callaghan, Heather Huet, Ryan M. Boomer, Taylor Hickman, Django Sussman, Allison Nelson, Luke Manlove, Kathleen E. McGinness, Tooba A. Cheema
Publikováno v:
Cancer Research. 77:4605-4605
B cell maturation antigen (BCMA) has recently emerged as an attractive therapeutic target in multiple myeloma. BCMA has restricted expression on plasma cells with little to no expression on other normal tissues, but is upregulated on the surface of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b967a976b2949823a1f347bdcc099c
https://doi.org/10.1158/1538-7445.am2017-4605
https://doi.org/10.1158/1538-7445.am2017-4605
Autor:
Birgit Schultes, R. Anthony Barnitz, Kathleen R. Whiteman, Lan Cao, Seth Ettenberg, John Shin, Tooba Cheema, Casey Judge, Ann Ranger, Geoffrey Hodge, Michael J. Vasconcelles, Kathleen E. McGinness, Ryan M. Boomer, Heather Huet
Publikováno v:
Blood. 128:3512-3512
The Antibody-Coupled T-cell Receptor (ACTR) platform is a universal engineered T cell therapy developed to mediate anti-tumor activity in combination with tumor-targeting antibodies. The ACTR construct is composed of the extracellular domain of CD16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786645f9403cca1900b996f565614c12
https://doi.org/10.1182/blood.v128.22.3512.3512
https://doi.org/10.1182/blood.v128.22.3512.3512
Autor:
Greg Motz, James Hemphill, Allison Nelson, Kathleen E. McGinness, Seth Ettenberg, Taylor Friedman, Taylor Hickman, Heather Huet, John Shin, Eugene Choi, Tooba Cheema, Ryan Boomer
Publikováno v:
Blood. 128:3362-3362
Adoptive T-cell therapy with single-chain variable fragment (scFv)-derived chimeric antigen receptors (CARs) has transformed cancer therapy. Nevertheless, treatment failure can occur and is often associated with loss of the targeted antigen-an outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113b785b9f6dd78c0b9f5b841d185896
https://doi.org/10.1182/blood.v128.22.3362.3362
https://doi.org/10.1182/blood.v128.22.3362.3362