Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Kathleen E. Brummel-Ziedins"'
Autor:
Mariana Vigiola Cruz, Jenna N. Luker, Bonnie C. Carney, Kathleen E. Brummel-Ziedins, Maria-Cristina Bravo, Thomas Orfeo, Jason H. Chen, Lauren T. Moffatt, Jeffrey W. Shupp
Publikováno v:
Thrombosis Journal, Vol 15, Iss 1, Pp 1-7 (2017)
Abstract Background A functional coagulation assay was used to investigate the extrinsic pathway of coagulation on citrated whole blood samples from healthy adult male Sprague Dawley rats using the mini cup and pin system. Methods Reference values fo
Externí odkaz:
https://doaj.org/article/dc81dbdcd50f46babbe8864b843bdcfa
Autor:
John W. Keyloun, Tuan D. Le, Thomas Orfeo, Kathleen E. Brummel-Ziedins, Maria C. Bravo, Matthew D. Kaye, Dana E. Bourne, Bonnie C. Carney, Kalev Freeman, Kenneth G. Mann, Anthony E. Pusateri, Jeffrey W. Shupp, Melissa M. McLawhorn, Lauren T. Moffatt, Rachael A. Callcut, Mitchell J. Cohen, Linda R. Petzold, Jeffrey D. Varner, Maria Cristina Bravo, Aarti Gautam, Rasha Hammamieh, Marti Jett
Publikováno v:
Journal of Surgical Research. 274:169-177
Proposed mechanisms of acute traumatic coagulopathy (ATC) include decreased clotting potential due to factor consumption and proteolytic inactivation of factor V (FV) and activated factor V (FVa) by activated protein C (aPC). The role of FV/FVa deple
Autor:
Laura S. Johnson, Jeffrey W. Shupp, Kathleen E. Brummel-Ziedins, Anthony E. Pusateri, Robert L. Ball, Lauren T. Moffatt, John W Keyloun, Thomas Orfeo, Tina L Palmieri
Publikováno v:
Shock (Augusta, Ga.), vol 54, iss 2
Shock (Augusta, Ga.)
Shock (Augusta, Ga.)
Burn-induced coagulopathy is not well understood, and consensus on diagnosis, prevention, and treatments are lacking. In this review, literature on burn-induced (and associated) coagulopathy is presented along with the current understanding of the ef
Autor:
Maria Cristina Bravo, Melissa M McLawhorn, Laura S. Johnson, Anthony E. Pusateri, John W Keyloun, Lauren T. Moffatt, Tuan D. Le, Jeffrey W. Shupp, Kathleen E Brummel-Ziedins, Thomas Orfeo
Publikováno v:
Journal of burn careresearch : official publication of the American Burn Association. 43(2)
Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury (IHI) increases morbidity and mortality. The aim of this work is to identify associations between IHI, coagulation homeostasis, vascular endothe
Autor:
Rachel LeCover, Kathleen E. Brummel-Ziedins, Thomas Orfeo, Jeffrey D. Varner, Anthony E. Pusateri, Maria Cristina Bravo
Publikováno v:
IFAC-PapersOnLine. 52:94-100
Thromboelastic testing provides an assessment of a patient’s coagulation and fibrinolytic systems. In recent years, thromboelastic testing has become an important point of care technique. However, its direct connection with the underlying biochemis
Autor:
Bonnie C. Carney, Robert L. Ball, Jeffrey W. Shupp, Tuan D. Le, Melissa M McLawhorn, Kathleen E Brummel-Ziedins, John W Keyloun, Anthony E. Pusateri, Thomas Orfeo, Lauren T. Moffatt, Maria Christina Bravo
Publikováno v:
Shock (Augusta, Ga.)
Objective: The aim of this study is to evaluate the association between burn injury and admission plasma levels of Syndecan-1 (SDC-1) and Tissue Factor Pathway Inhibitor (TFPI), and their ability to predict 30-day mortality. Background: SDC-1 and TFP
Autor:
Jonathan H Foley, Thomas Orfeo, Anetta Undas, Kelley C McLean, Ira M Bernstein, Georges-Etienne Rivard, Kenneth G Mann, Stephen J Everse, Kathleen E Brummel-Ziedins
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54728 (2013)
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin time (PT) cannot predict thrombotic or bleeding risk. Since thrombin generation is central to haemorrhage control and when unregulated, is the like
Externí odkaz:
https://doaj.org/article/b368f046e2a348a18ddb94fef059ca6b
Autor:
John W Keyloun, Kathleen E Brummel-Ziedins, Thomas Orfeo, Anthony E. Pusateri, Lauren T. Moffatt, R. A. Callcut, Melissa M McLawhorn, Jeffrey W. Shupp, Tuan D. Le
Publikováno v:
BJS Open
Introduction Abnormal fibrinolysis early after injury has been associated with increased mortality in trauma patients, but no studies have addressed patients with burn injury. This prospective cohort study aimed to characterize fibrinolytic phenotype
Autor:
Kathleen E Brummel-Ziedins, Thomas Orfeo, Peter W Callas, Matthew Gissel, Kenneth G Mann, Edwin G Bovill
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44378 (2012)
The underlying cause of thrombosis in a large protein C (PC) deficient Vermont kindred appears to be multicausal and not explained by PC deficiency alone. We evaluated the contribution of coagulation factors to thrombin generation in this population
Externí odkaz:
https://doaj.org/article/f074f548dd204369b3ff82ec65902d45
Autor:
David Chadwick, Russell P. Tracy, Álvaro H. Borges, Kathleen E. Brummel-Ziedins, Matthew Gissel, Jacqueline Neuhaus, Jason V. Baker, James D. Neaton, Sean Emery
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Brummel-Ziedins, K E, Gissel, M, Neuhaus, J, Borges, Á H, Chadwick, D R, Emery, S, Neaton, J D, Tracy, R P, Baker, J V & INSIGHT SMART, ESPRIT Study Groups 2018, ' In silico thrombin generation : Plasma composition imbalance and mortality in human immunodeficiency virus ', Research and Practice in Thrombosis and Haemostasis, vol. 2, no. 4, pp. 708-717 . https://doi.org/10.1002/rth2.12147
Brummel-Ziedins, K E, Gissel, M, Neuhaus, J, Borges, Á H, Chadwick, D R, Emery, S, Neaton, J D, Tracy, R P, Baker, J V & INSIGHT SMART, ESPRIT Study Groups 2018, ' In silico thrombin generation : Plasma composition imbalance and mortality in human immunodeficiency virus ', Research and Practice in Thrombosis and Haemostasis, vol. 2, no. 4, pp. 708-717 . https://doi.org/10.1002/rth2.12147
Background: Effective HIV treatment with antiretroviral therapy has prolonged survival and shifted causes of death to non-AIDS illnesses such as cardiovascular disease. We have shown that inflammation and HIV viral load associate with pro- and antico