Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Kathleen E McGrath"'
Autor:
Brenda Cadiz-Rivera, George Fromm, Christina de Vries, Jennifer Fields, Kathleen E McGrath, Steven Fiering, Michael Bulger
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e92947 (2014)
In mammals, the complex tissue- and developmental-specific expression of genes within the β-globin cluster is known to be subject to control by the gene promoters, by a locus control region (LCR) located upstream of the cluster, and by sequence elem
Externí odkaz:
https://doaj.org/article/69364aba8e8e41969c241971a8c2e6d4
Autor:
Preeti Maurya, Sara K. Ture, Chen Li, Kristin M. Scheible, Kathleen E. McGrath, James Palis, Craig N. Morrell
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:873-885
Background: Thrombocytopenia is common in preterm neonates. Platelet transfusions are sometimes given to thrombocytopenic neonates with the hope of reducing the bleeding risk, however, there are little clinical data to support this practice, and plat
Autor:
Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression
Externí odkaz:
https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
Autor:
Yu-Shan Huang, Luis F. Delgadillo, Kathryn H. Cyr, Paul D. Kingsley, Xiuli An, Kathleen E. McGrath, Narla Mohandas, John G. Conboy, Richard E. Waugh, Jiandi Wan, James Palis
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly and form a unique membrane skeleton, composed of spectrin, 4.1R-complex, and ankyr
Externí odkaz:
https://doaj.org/article/59ae1bf1686e4ba7bff3a96a98431c78
Autor:
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Ji-Ying Song, Cor Lieftink, Matilda Ayidah, Colin E. J. Pritchard, Judith Vivié, Kathleen E. Mcgrath, Ivo J. Huijbers, Sjaak Philipsen, Marieke von Lindern, Wilbert Zwart, Roderick L. Beijersbergen, James Palis, Paul C. M. van den Berk, Heinz Jacobs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(4):e2216055120. National Academy of Sciences
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of
Autor:
Noah Salama, Olivia Lynch, Emily R Quarato, Yuko Kawano, Benjamin Rodems, Eric Cefaloni, Tzu-Chieh Ho, Kathleen E. McGrath, Michael W. Becker, Jane L. Liesveld, Paula M Vertino, James Palis, Jeevisha Bajaj, Laura M. Calvi
Publikováno v:
Blood. 140:9757-9758
Autor:
Michael H. Atkins, Rebecca Scarfò, Kathleen E. McGrath, Donghe Yang, James Palis, Andrea Ditadi, Gordon M. Keller
Publikováno v:
Journal of Experimental Medicine. 219
In the mouse, the first hematopoietic cells are generated in the yolk sac from the primitive, erythro-myeloid progenitor (EMP) and lymphoid programs that are specified before the emergence of hematopoietic stem cells. While many of the yolk sac–der
Autor:
Jayme L. Olsen, Kathleen E. McGrath, Kristin Murphy, Taylor Schofield, Michael Getman, Mohandas Narla, Lionel Blanc, Vincent P Schulz, Patrick G. Gallagher, Laurie A. Steiner, James Palis
Publikováno v:
Blood. 140:8152-8152
Autor:
Travis Nemkov, Paul D. Kingsley, Monika Dzieciatkowska, Jeffrey Malik, Kathleen E. McGrath, Kirk C. Hansen, Angelo D’Alessandro, James Palis
Publikováno v:
Blood advances. 6(10)
Primitive erythropoiesis is a critical component of the fetal cardiovascular network and is essential for the growth and survival of the mammalian embryo. The need to rapidly establish a functional cardiovascular system is met, in part, by the intrav
Autor:
Laura M. Calvi, Edward Ayoub, James Palis, Kathleen E. McGrath, Archibald S. Perkins, Allison J. Li, Michael P Wilson, Yi Zhang, Benjamin J. Frisch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1