Výsledky vyhledávání - "Kathleen E Fischer"

Akademický článek

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

Autor: Kathleen E Fischer, Jonathan A L Gelfond, Vanessa Y Soto, Chul Han, Shinichi Someya, Arlan Richardson, Steven N Austad

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126644 (2015)

Rapamycin, an mTOR inhibitor, has been shown to extend lifespan in a range of model organisms. It has been reported to extend lifespan in multiple strains of mice, administered chronically or acutely early or late in life. The ability of rapamycin to

Externí odkaz: https://doaj.org/article/42ea1c25437542dca4fdeb96acdbc959

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Data from eRapa Restores a Normal Life Span in a FAP Mouse Model

Autor: Zelton Dave Sharp, Tyler J. Curiel, Vincent Hurez, Lishi Sun, Gene Hubbard, Kruthi Murthy, Lauren Sloane, Kathleen E. Fischer, Martin Javors, Randy Strong, Diane Jones, Sherry G. Dodds, Carolina B. Livi, Paul Hasty

Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk for colon cancer. ApcMin/+ mice exhibit multiple intestinal neoplasia (MIN) that causes anemi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf0634f81327f10016a3b4b0ab3b7c
https://doi.org/10.1158/1940-6207.c.6544299.v1

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Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways

Autor: Zhengdong Zhang, Shixiang Sun, Jan Vijg, Steven N. Austad, Kathleen E. Fischer, Ryan R. White

Publikováno v: GeroScience

Freshwater polyps of the genus Hydra do not age. However, temperature stress induces aging and a shift from reproduction by asexual budding to sexual gamete production in a cold-sensitive (CS) strain of H. oligactis. We sequenced the transcriptome of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07358ad2c9c80efb3c4f2a085e36a91
https://pubmed.ncbi.nlm.nih.gov/32578072

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Deficient autophagy in epithelial stem cells drives aging in the freshwater cnidarian Hydra

Autor: Steven N. Austad, Nenad Slavko Suknovic, Kazadi Ekundayo, Quentin Schenkelaars, Brigitte Galliot, Yvan Wenger, Christoph Ruediger Bauer, Wanda Christa Buzgariu, Szymon Tomczyk, Kathleen E. Fischer

Publikováno v: Development (Cambridge, England)
Development, Vol. 147, No dev177840 (2020) pp. 1-16

Hydra possesses three distinct stem cell populations that continuously self-renew and prevent aging in Hydra vulgaris. However, sexual animals from the H. oligactis cold-sensitive strain Ho_CS develop an aging phenotype upon gametogenesis induction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604c469d1167a688a643e8818ba77af8
http://europepmc.org/articles/PMC6983715

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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

Autor: Jordan B. Jahrling, Veronica Galvan, Stacy A. Hussong, Kathleen E. Fischer, Ai-Ling Lin, Stephen F. Hernandez, Matthew J. Hart, Candice E. Van Skike, Vanessa Y. Soto, Raquel R. Burbank, James Cuvillier, Steven N. Austad, Jonathan J. Halloran, Martin A. Javors

Publikováno v: Aging Cell

Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with aging and is one of the earliest events in the pathogenesis of Alzheimer'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee55649ebf509d9122466500262854
https://doi.org/10.1111/acel.13057

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A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

Autor: Jonathan Gelfond, Kathleen E. Fischer, Arlan Richardson, Jessica M. Hoffman, Vanessa Y. Soto, Steven N. Austad, Lauren B. Sloane

Publikováno v: Aging (Albany NY)

Lifespan provides a discrete metric that is intuitively appealing and the assumption has been that healthspan is extended concomitant with lifespan. Medicine has been more successful at extending life than preserving health during aging. Intervention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb28886a929404bb399100ce75fc9825
https://doi.org/10.18632/aging.101059

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Salt-sensitivity of σHand Spo0A prevents sporulation ofBacillus subtilisat high osmolarity avoiding death during cellular differentiation

Autor: Nils Widderich, Kathleen E. Fischer, Erhard Bremer, Fabian M. Commichau, Christopher D. A. Rodrigues, Fernando H. Ramírez-Guadiana, David Z. Rudner

Publikováno v: Molecular Microbiology. 100:108-124

The spore-forming bacterium Bacillus subtilis frequently experiences high osmolarity as a result of desiccation in the soil. The formation of a highly desiccation-resistant endospore might serve as a logical osmostress escape route when vegetative gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94ecabc05570015abd2ef0f6c9599967
https://doi.org/10.1111/mmi.13304

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Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

Autor: Michael Kinter, Daniel Pulliam, Arlan Richardson, Kaitlyn Riddle, Wilson C. Fok, Gavin Pharaoh, Holly Van Remmen, Vanessa Y. Soto, Shauna Hill, Jonathan D. Wren, Sathyaseelan S. Deepa, Vivian Diaz, Carlo Viscomi, Constantin Georgescu, Kathleen E. Fischer

Publikováno v: Aging Cell

Summary Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes in metabolism (reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d1966da85be4d1e958eb572e6f219
http://hdl.handle.net/11577/3321362

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