Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kathleen E Delgiorno"'
Autor:
Maya Saison-Ridinger, Kathleen E DelGiorno, Tejia Zhang, Annabelle Kraus, Randall French, Dawn Jaquish, Crystal Tsui, Galina Erikson, Benjamin T Spike, Maxim N Shokhirev, Christopher Liddle, Ruth T Yu, Michael Downes, Ronald M Evans, Alan Saghatelian, Andrew M Lowy, Geoffrey M Wahl
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189051 (2017)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and bec
Externí odkaz:
https://doaj.org/article/23aab20296124703a94f74164e9e8040
Autor:
Kathleen E DelGiorno, Jason W Tam, Jason C Hall, Gangadaar Thotakura, Howard C Crawford, Adrianus W M van der Velden
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e92807 (2014)
Pancreatitis, a known risk factor for the development of pancreatic ductal adenocarcinoma, is a serious, widespread medical condition usually caused by alcohol abuse or gallstone-mediated ductal obstruction. However, many cases of pancreatitis are of
Externí odkaz:
https://doaj.org/article/5b70faa214d64b718cdbce884435c459
Autor:
Wahida H Ali, Qin Chen, Kathleen E Delgiorno, Wenjuan Su, Jason C Hall, Tsunaki Hongu, Huasong Tian, Yasunori Kanaho, Gilbert Di Paolo, Howard C Crawford, Michael A Frohman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55325 (2013)
Cell migration and phagocytosis ensue from extracellular-initiated signaling cascades that orchestrate dynamic reorganization of the actin cytoskeleton. The reorganization is mediated by effector proteins recruited to the site of activity by locally-
Externí odkaz:
https://doaj.org/article/4ccb4dc8e5cf4eb0ac4dc64d3575e3de
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/701bd9cc40c84f01adc79b9847285b4d
Autor:
Jahg Wong, Vincent Q. Trinh, Nidhi Jyotsana, Jumanah F. Baig, Frank Revetta, Chanjuan Shi, Anna L. Means, Kathleen E. DelGiorno, Marcus Tan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Hepatocyte Nuclear Factor 4-alpha (HNF4α) comprises a nuclear receptor superfamily of ligand-dependent transcription factors that yields twelve isoforms in humans, classified into promoters P1 or P2-associated groups with specific functions
Externí odkaz:
https://doaj.org/article/2e7c001fbfc04a259a20bc76eaa9db29
Autor:
Vikas B. Gubbala, Nidhi Jytosana, Vincent Q. Trinh, H. Carlo Maurer, Razia F. Naeem, Nikki K. Lytle, Zhibo Ma, Steven Zhao, Wei Lin, Haiyong Han, Yu Shi, Tony Hunter, Pankaj K. Singh, Kenneth P. Olive, Marcus C.B. Tan, Susan M. Kaech, Geoffrey M. Wahl, Kathleen E. DelGiorno
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 4, Pp 682-697 (2022)
Background and Aims: Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the cell types responsib
Externí odkaz:
https://doaj.org/article/feecc0f1541240d993d5e3ead6ccabdb
Autor:
Natalie Luhtala, Kathleen E. DelGiorno
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/dc1fd887312049438322625782d85658
Autor:
Leah R. Caplan, Vera Vavinskaya, David G. Gelikman, Nidhi Jyotsana, Vincent Q. Trinh, Kenneth P. Olive, Marcus C. B. Tan, Kathleen E. DelGiorno
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of only 11%, due, in part, to late diagnosis, making the need to understand early events in tumorigenesis critical. Acinar-to-ductal metaplasia (ADM), when n
Externí odkaz:
https://doaj.org/article/0ac378f50b50461799a05fbe2e446bf9
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione synthesis; a process that protects cells from oxidative stress
Externí odkaz:
https://doaj.org/article/232f324f49784ef3a2fb3e4f381a79f8
Publikováno v:
Gut. 72:1211-1219
Recent advances in single-cell RNA sequencing and bioinformatics have drastically increased our ability to interrogate the cellular composition of traditionally difficult to study organs, such as the pancreas. With the advent of these technologies an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af46578eb2cd8495b87796378cd5671
https://doi.org/10.1136/gutjnl-2022-329313
https://doi.org/10.1136/gutjnl-2022-329313