Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial CellsSummary

Autor: Tyler J. Caron, Kathleen E. Scott, Nishita Sinha, Sureshkumar Muthupalani, Mahnoor Baqai, Lay-Hong Ang, Yue Li, Jerrold R. Turner, James G. Fox, Susan J. Hagen

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 783-801 (2021)

Background & Aims: Tight junctions form a barrier to the paracellular passage of luminal antigens. Although most tight junction proteins reside within the apical tight junction complex, claudin-18 localizes mainly to the basolateral membrane where it

Externí odkaz: https://doaj.org/article/9a1b277e98b940a79bfd9b227fc8c915

Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells

Autor: Mahnoor Baqai, James G. Fox, Susan J. Hagen, Nishita Sinha, Yue Li, Tyler J. Caron, Jerrold R. Turner, Sureshkumar Muthupalani, Lay-Hong Ang, Kathleen E Scott

Publikováno v: Elsevier
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 783-801 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Tight junctions form a barrier to the paracellular passage of luminal antigens. Although most tight junction proteins reside within the apical tight junction complex, claudin-18 localizes mainly to the basolateral membrane where its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fe29aeb8bf6cde834e2ffb0c105a3b
https://doi.org/10.1016/j.jcmgh.2020.10.005

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis

Autor: Rudolf Jaenisch, Zhongming Ge, Carolyn M. Madden, Kathleen E Scott, Johanne T. Jacobsen, Tyler J. Caron, Gabriel D. Victora, Vasudevan Bakthavatchalu, Katherine J. Wert, Anthony Mannion, Yan Feng, Alexis García, James G. Fox

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 3, p e0194443 (2018)

Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to clinical trials. However, CRISPR/Cas9 gene editing of the Wsh/Wsh mouse strain to create an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8213d221682af4164fa70a8430fd594f
http://europepmc.org/articles/PMC5858775

Evaluation of Best Practices for the Euthanasia of Zebra Finches (

Autor: Kathleen E, Scott, Lauren A, Bracchi, Mia T, Lieberman, Nichola J, Hill, Tyler J, Caron, Mary M, Patterson

Publikováno v: Journal of the American Association for Laboratory Animal Science : JAALAS. 56(6)

Although zebra finches (Taeniopygia guttata) have been used in biomedical research for many years, no published reports are available about euthanizing these small birds. In this study, we compared 5 methods for zebra finch euthanasia: sodium pentoba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3392185358b09b7ac6a6894132aec035
https://pubmed.ncbi.nlm.nih.gov/29256376

Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier

Autor: Tyler J. Caron, Kathleen E Scott, Susan J. Hagen, James G Fox

Publikováno v: Baishideng Publishing Group

Long-term chronic infection with Helicobacter pylori (H. pylori ) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer, tight junction dysfunction is thought to occur and serve as a risk factor by pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2ac5aa7e4966bebc1ae54bf23012e6
https://orcid.org/0000-0002-2007-8724