Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kathleen E, Prosser"'
Autor:
Gregory A. MacNeil, Stephanie W. Chang, Kathleen E. Prosser, Eric Ye, Devon Heroux, Andrew R. Lewis, Marcel Bally, Charles J. Walsby
Publikováno v:
Chemical Communications. 59:623-626
Fluorine labelling of a Ru(iii) chemotherapeutic candidate enables studies of reactivity in tissues by 19F nuclear magnetic resonance imaging methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35cffa33cc55b1ac82b00ec1943fb63
https://doi.org/10.1039/d2cc04830b
https://doi.org/10.1039/d2cc04830b
Autor:
Gregory A, MacNeil, Stephanie W, Chang, Kathleen E, Prosser, Eric, Ye, Devon, Heroux, Andrew R, Lewis, Marcel, Bally, Charles J, Walsby
Publikováno v:
Chemical communications (Cambridge, England).
The application of CF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5deb390c189fee388661484863068cb
https://pubmed.ncbi.nlm.nih.gov/36537324
https://pubmed.ncbi.nlm.nih.gov/36537324
Autor:
Christine N. Morrison, Kathleen E. Prosser, Ryjul W. Stokes, Anna Cordes, Nils Metzler-Nolte, Seth M. Cohen
Publikováno v:
Chemical science, vol 13, iss 32
Correction for ‘Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery’ by Christine N. Morrison et al., Chem. Sci., 2020, 11, 1216–1225, https://doi.org/10.1039/C9SC05586J.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7e3afa84977ed13d9d9eaa2f29973a
https://escholarship.org/uc/item/429861st
https://escholarship.org/uc/item/429861st
Autor:
Kathleen E. Prosser, Gregory A. MacNeil, Rahul T. Kadakia, Annica Chu, Da Xie, Emily L. Que, Bryton R. Varju, Charles J. Walsby
Publikováno v:
Chemistry – A European Journal. 27:9839-9849
Targeting the low-oxygen (hypoxic) environments found in many tumours by using redox-active metal complexes is a strategy that can enhance efficacy and reduce the side effects of chemotherapies. We have developed a series of CuII complexes with tride
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4698583a42973a9b295b71a5e4db61
https://doi.org/10.1002/chem.202100603
https://doi.org/10.1002/chem.202100603
Publikováno v:
Dalton Transactions. 49:8841-8845
Herein, we report the room temperature aqueous synthesis of the Zr(iv)-based metal-organic framework UiO-66 and a series of functionalized derivatives through postsynthetic exchange from a perfluorinated UiO-66-F4 precursor. All synthesized MOFs in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebef334cbf3b19f1368a43ec6303f01
https://doi.org/10.1039/d0dt01939a
https://doi.org/10.1039/d0dt01939a
Autor:
Seth M. Cohen, Kathleen E. Prosser, Mark Kalaj, Johannes Karges, Hyeonglim Seo, Benjamin L. Dick
Publikováno v:
Inorganic chemistry, vol 60, iss 22
Inorg Chem
Inorg Chem
Bioisosteres are a useful approach to address pharmacokinetic liabilities and improve drug-like properties. Specific to developing metalloenzyme inhibitors, metal-binding pharmacophores (MBPs) have been combined with bioisosteres, to produce metal-bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70680a258be468e465d6adc0d0d6dccc
https://escholarship.org/uc/item/1g04h0s2
https://escholarship.org/uc/item/1g04h0s2
Autor:
Zeev Gross, Tim Storr, Kathleen E. Prosser, Atif Mahammed, Luiza M.F. Gomes, Jason R. Smith, Michael A. Silverman, Charles J. Walsby
Publikováno v:
Chemical Science. 10:1634-1643
Alzheimer's disease (AD) is a multifaceted disease that is characterized by increased oxidative stress, metal-ion dysregulation, and the formation of intracellular neurofibrillary tangles and extracellular amyloid-β (Aβ) aggregates. In this work we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e03d8f1830f55bc5d3b1eb7d76c6a73a
https://doi.org/10.1039/c8sc04660c
https://doi.org/10.1039/c8sc04660c
Publikováno v:
Chemical communications (Cambridge, England), vol 57, iss 40
Chem Commun (Camb)
Chem Commun (Camb)
This study demonstrates the screening of a collection of twelve (19)F-tagged metal-binding pharmacophores (MBPs) against the Zn(II)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by (19)F NMR. The isomorphous replacement of Zn(II) by Co(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399ddf2c34f3c8df9b2af817d6dbe54e
https://escholarship.org/uc/item/2jd1s6ck
https://escholarship.org/uc/item/2jd1s6ck
Publikováno v:
ACS medicinal chemistry letters, vol 11, iss 6
ACS Med Chem Lett
ACS Med Chem Lett
[Image: see text] The 3-dimensional (3D) structure of therapeutics and other bioactive molecules is an important factor in determining the strength and selectivity of their protein–ligand interactions. Previous efforts have considered the strain in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cad92bd125498a60d6fa6c59aeca5a8
https://escholarship.org/uc/item/7q56h3x9
https://escholarship.org/uc/item/7q56h3x9
Publikováno v:
Chemical Communications. 58:3071-3071
Correction for ‘19F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes’ by Kathleen E. Prosser et al., Chem. Commun., 2021, 57, 4934–4937, DOI: 10.1039/D1CC01231B.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9239dd7b8a2ccb6ce3643d7e98f8ddc
https://doi.org/10.1039/d2cc90072f
https://doi.org/10.1039/d2cc90072f