Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kathleen Deponte"'
mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis
Autor:
Jaqueline Matias, Yingjun Cui, Geoffrey E. Lynn, Kathleen DePonte, Emily Mesquita, Hiromi Muramatsu, Mohamad G. Alameh, Garima Dwivedi, Ying K. Tam, Norbert Pardi, Drew Weissman, Erol Fikrig
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-5 (2024)
Abstract 19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore,
Externí odkaz:
https://doaj.org/article/6ba6b44c2bf94f4381c76ab31be850f1
Autor:
Yingjun Cui, Jaqueline Matias, Xiaotian Tang, Balasubramanian Cibichakravarthy, Kathleen DePonte, Ming-Jie Wu, Erol Fikrig
Publikováno v:
Ticks and Tick-Borne Diseases, Vol 15, Iss 1, Pp 102279- (2024)
Guinea pigs repeatedly exposed to Ixodes scapularis develop acquired resistance to the ticks (ATR). The molecular mechanisms of ATR have not been fully elucidated, and partially involves immune responses to proteins in tick saliva. In this study, we
Externí odkaz:
https://doaj.org/article/bfffc09d16444118ade1ee78c48ee114
Autor:
Sukanya Narasimhan, Nallakkandi Rajeevan, Morven Graham, Ming-Jie Wu, Kathleen DePonte, Solenne Marion, Orlanne Masson, Anya J. O’Neal, Joao H. F. Pedra, Daniel E. Sonenshine, Erol Fikrig
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Background Ixodes scapularis is the predominant tick vector of Borrelia burgdorferi, the agent of Lyme disease, in the USA. Molecular interactions between the tick and B. burgdorferi orchestrate the migration of spirochetes from the midgut t
Externí odkaz:
https://doaj.org/article/4654c8393ab74cbdb11c666caf8a7d85
Autor:
Gunjan Arora, Andaleeb Sajid, Yu-Min Chuang, Yuemei Dong, Akash Gupta, Kristen Gambardella, Kathleen DePonte, Lionel Almeras, George Dimopolous, Erol Fikrig
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Malaria is caused when Plasmodium sporozoites are injected along with saliva by an anopheline mosquito into the dermis of a vertebrate host. Arthropod saliva has pleiotropic effects that can influence local host responses, pathogen transmiss
Externí odkaz:
https://doaj.org/article/92e5b4645bb541b8bc0a49c53897ecab
Autor:
Dana K. Shaw, Xiaowei Wang, Lindsey J. Brown, Adela S. Oliva Chávez, Kathryn E. Reif, Alexis A. Smith, Alison J. Scott, Erin E. McClure, Vishant M. Boradia, Holly L. Hammond, Eric J. Sundberg, Greg A. Snyder, Lei Liu, Kathleen DePonte, Margarita Villar, Massaro W. Ueti, José de la Fuente, Robert K. Ernst, Utpal Pal, Erol Fikrig, Joao H. F. Pedra
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 co
Externí odkaz:
https://doaj.org/article/e93ff65b05c44e12b7a08eacf7918704
Autor:
Sukanya Narasimhan, Oriana Perez, Sara Mootien, Kathleen DePonte, Raymond A Koski, Erol Fikrig, Michel Ledizet
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68012 (2013)
Ixodes scapularis, the black-legged tick, vectors several human pathogens including Borrelia burgdorferi, the agent of Lyme disease in North America. Pathogen transmission to the vertebrate host occurs when infected ticks feed on the mammalian host t
Externí odkaz:
https://doaj.org/article/35b829a70eb547e1b0acafdd06582523
Autor:
Tim J Schuijt, Sukanya Narasimhan, Sirlei Daffre, Kathleen DePonte, Joppe W R Hovius, Cornelis Van't Veer, Tom van der Poll, Kamran Bakhtiari, Joost C M Meijers, Eric T Boder, Alje P van Dam, Erol Fikrig
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15926 (2011)
Repeated exposure of rabbits and other animals to ticks results in acquired resistance or immunity to subsequent tick bites and is partially elicited by antibodies directed against tick antigens. In this study we demonstrate the utility of a yeast su
Externí odkaz:
https://doaj.org/article/e8a59f8366f542689f5da9feb4f453f7
Autor:
Sukanya Narasimhan, Kathleen Deponte, Nancy Marcantonio, Xianping Liang, Thomas E Royce, Kenneth F Nelson, Carmen J Booth, Benjamin Koski, John F Anderson, Fred Kantor, Erol Fikrig
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e451 (2007)
In North America, the black-legged tick, Ixodes scapularis, an obligate haematophagus arthropod, is a vector of several human pathogens including Borrelia burgdorferi, the Lyme disease agent. In this report, we show that the tick salivary gland trans
Externí odkaz:
https://doaj.org/article/78d0b7c23b144a3398503515f4260c03
Autor:
Girish Neelakanta, Xin Li, Utpal Pal, Xianzhong Liu, Deborah S Beck, Kathleen DePonte, Durland Fish, Fred S Kantor, Erol Fikrig
Publikováno v:
PLoS Pathogens, Vol 3, Iss 3, p e33 (2007)
Survival of Borrelia burgdorferi in ticks and mammals is facilitated, at least in part, by the selective expression of lipoproteins. Outer surface protein (Osp) A participates in spirochete adherence to the tick gut. As ospB is expressed on a bicistr
Externí odkaz:
https://doaj.org/article/0a20552e92044d548c59cf6e041e0cd3
Autor:
Jesus G. Valenzuela, Sukanya Narasimhan, Jaqueline Matias, Husrev Diktas, Gunjan Arora, Andaleeb Sajid, Geoffrey E. Lynn, Kathleen DePonte, Norbert Pardi, Erol Fikrig, Drew Weissman, Cheyne Kurokawa
Publikováno v:
Vaccine
Guinea pigs exposed to multiple infestations with Ixodes scapularis ticks develop acquired resistance to ticks, which is also known as tick immunity. The I. scapularis salivary components that contribute to tick immunity are likely multifactorial. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b837fca50e945f931ba59b66f7d3fc0
https://doi.org/10.1016/j.vaccine.2021.11.003
https://doi.org/10.1016/j.vaccine.2021.11.003