Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kathleen D. Metzler"'
Autor:
Kathleen D. Metzler, Christian Goosmann, Aleksandra Lubojemska, Arturo Zychlinsky, Venizelos Papayannopoulos
Publikováno v:
Cell Reports, Vol 8, Iss 3, Pp 883-896 (2014)
Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion. However, during the formation of neutrophil extracellular traps (NETs), neutrophil elastase (NE) transl
Externí odkaz:
https://doaj.org/article/c05456111b6543e59c62a14bc2623df7
Autor:
Venizelos Papayannopoulos, Joachim Roesler, Dominique Reumaux, William M. Nauseef, Volker Wahn, Kathleen D. Metzler, Tobias A. Fuchs, Arturo Zychlinsky, Ilka Schulze
Publikováno v:
Blood. 117:953-959
The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable. Serious microbial infections, especially with Candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f477f1054eac74f75f9982d5637025
https://doi.org/10.1182/blood-2010-06-290171
https://doi.org/10.1182/blood-2010-06-290171
Publikováno v:
The Journal of Cell Biology
Neutrophil elastase escapes azurophilic granules, translocates to the nucleus, and degrades histones to promote chromatin decondensation necessary for NET formation.
Neutrophils release decondensed chromatin termed neutrophil extracellular traps
Neutrophils release decondensed chromatin termed neutrophil extracellular traps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f1f1909d3b10b68adf17aee96b428e
http://europepmc.org/articles/PMC3003309
http://europepmc.org/articles/PMC3003309
Autor:
Christian Goosmann, Kathleen D. Metzler, Aleksandra Lubojemska, Arturo Zychlinsky, Venizelos Papayannopoulos
Publikováno v:
Cell Reports
Cell Reports, Vol 8, Iss 3, Pp 883-896 (2014)
Cell Reports, Vol 8, Iss 3, Pp 883-896 (2014)
Summary Neutrophils contain granules loaded with antimicrobial proteins and are regarded as impermeable organelles that deliver cargo via membrane fusion. However, during the formation of neutrophil extracellular traps (NETs), neutrophil elastase (NE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d5defd38bf06d39eca76ef2e9d6b9a
https://pubmed.ncbi.nlm.nih.gov/25066128
https://pubmed.ncbi.nlm.nih.gov/25066128
Publikováno v:
Annual review of immunology. 30
Neutrophils are the most abundant white blood cells in circulation, and patients with congenital neutrophil deficiencies suffer from severe infections that are often fatal, underscoring the importance of these cells in immune defense. In spite of neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba305be6b577b8dc2aaad21335bd8f6a
https://pubmed.ncbi.nlm.nih.gov/22224774
https://pubmed.ncbi.nlm.nih.gov/22224774