Výsledky vyhledávání - "Kathleen C. M. Campbell"

The audiogram: Detection of pure-tone stimuli in ototoxicity monitoring and assessments of investigational medicines for the inner ear

Autor: Colleen G. Le Prell, Carmen C. Brewer, Kathleen C. M. Campbell

Publikováno v: J Acoust Soc Am

Pure-tone thresholds have long served as a gold standard for evaluating hearing sensitivity and documenting hearing changes related to medical treatments, toxic or otherwise hazardous exposures, ear disease, genetic disorders involving the ear, and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b430a95d8909ca9b8bfa9fe2a36d3b6
https://pubmed.ncbi.nlm.nih.gov/35931504

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D-methionine administered as late as 36 hours post-noise exposure rescues from permanent threshold shift and dose-dependently increases serum antioxidant levels

Autor: Kathleen C. M. Campbell, Nicole Cosenza, Robert Meech, Michael Buhnerkempe, Jun Qin, Leonard Rybak, Daniel J. Fox

Publikováno v: International Journal of Audiology. 62:151-158

To elucidate D-methionine's (D-met) dose and time rescue parameters from steady-state or impulse noise-induced permanent threshold shift (PTS) and determine D-met rescue's influence on serum and cochlear antioxidant levels.Five D-met doses at 0, 50,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8983c41d8365274b627b0d4988608f2f
https://doi.org/10.1080/14992027.2021.2022790

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Oral D-methionine protects against cisplatin-induced hearing loss in humans: phase 2 randomized clinical trial in India

Autor: Daniel A. Hamstra, A. Rehemtulla, Michael G. Buhnerkempe, Kathleen C. M. Campbell, Brian D. Ross, Prasad S. Sunkara

Publikováno v: International journal of audiology. 61(8)

Objective: This exploratory Phase 2 clinical trial is the first determining safety and efficacy of oral D-methionine (D-met) in reducing cisplatin-induced ototoxicity.Design: Randomised parallel do...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66fe122bb6982a04b8ef204f6653326
https://pubmed.ncbi.nlm.nih.gov/34622731

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D-methionine immediate and continued rescue after noise exposure does not prevent temporary threshold shift but alters cochlear and serum antioxidant levels

Autor: Robert P. Meech, Michael G. Buhnerkempe, Jun Qin, Leonard P. Rybak, Nicole Cosenza, Kathleen C. M. Campbell, Daniel J. Fox

Publikováno v: International journal of audiology. 61(9)

Objective Determine if D-methionine (D-met) rescue prevents temporary threshold shift (TTS) from steady-state or impulse noise and determine D-met's impact on serum and cochlear antioxidant levels. Design D-met at 50, 100 or 200 mg/kg/doses were admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d6454510c922d25637d67f07d7dfbf
https://pubmed.ncbi.nlm.nih.gov/34369249

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Drug-Induced Ototoxicity: Diagnosis and Monitoring

Autor: Kathleen C. M. Campbell, Colleen G. Le Prell

Publikováno v: Drug Safety. 41:451-464

Ototoxicity diagnosis and management has historically been approached using a variety of methods. However, in recent years a consensus on useful and practical approaches has been developed through clinical guidelines of the American Speech Language H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1413e693e2e9dc5583309b2625334ba0
https://doi.org/10.1007/s40264-017-0629-8

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Guidelines for Auditory Threshold Measurement for Significant Threshold Shift

Autor: Michael E. Hoffer, Kathleen C. M. Campbell, Jonathan Kil, Colleen G. Le Prell, Tanisha L. Hammill

Publikováno v: Otology & Neurotology. 37:e263-e270

The purpose of this article is to provide guidelines for determining a Significant Noise-Induced Threshold Shift in clinical trials involving human populations. The article reviews recommendations for the standards to be referenced for human subjects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28b77817339764034fc3ab17c52d2ae
https://doi.org/10.1097/mao.0000000000001135

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D-methionine (D-met) significantly reduces kanamycin-induced ototoxicity in pigmented guinea pigs

Autor: Seth M. Martin, Tim L. Hargrove, Robert P. Meech, Steven J. Verhulst, Kathleen C. M. Campbell, Daniel J. Fox

Publikováno v: International Journal of Audiology. 55:273-278

Test D-methionine (D-met) as an otoprotectant from kanamycin-induced ototoxicity and determine the lowest maximally protective D-met dose.Auditory brainstem responses (ABR) were measured at 4, 8, 14, and 20 kHz at baseline and two, four, and six week

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314e78a6f30b8bf0e8b5d5b9b12e975e
https://doi.org/10.3109/14992027.2016.1143980

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Double-blind placebo-controlled multicenter phase II trial to evaluate D-methionine in preventing/reducing oral mucositis induced by radiation and chemotherapy for head and neck cancer

Autor: Sudhir Borgonha, Avraham Eisbruch, Kuei C. Lee, Babu Phillip, Prasad S. Sunkara, Brian D. Ross, Alnawaz Rehemtulla, Kathleen C. M. Campbell, Daniel A. Hamstra

Publikováno v: Headneck. 40(7)

Background The purpose of this study was to test if oral D-methionine (D-met) reduced mucositis during chemoradiotherapy. Methods We conducted a placebo-controlled double-blind randomized phase II trial of D-met (100 mg/kg p.o. b.i.d.) testing the ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf626791c7454dcfc3a35a4b7d2ea6d
https://pubmed.ncbi.nlm.nih.gov/29473247

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