Hydroxylated Polychlorinated Biphenyls Selectively Bind Transthyretin in Blood and Inhibit Amyloidogenesis: Rationalizing Rodent PCB Toxicity

Autor: Stephen Safe, Satheesh K. Palaninathan, Hans E. Purkey, James C. Sacchettini, Jeffery W. Kelly, Craig P. Smith, Kathleen C. Kent

Publikováno v: Chemistry & Biology. 11(12):1719-1728

SummaryPolychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-PCBs) are known to bind to transthyretin (TTR) in vitro, possibly explaining their bioaccumulation, rodent toxicity, and presumed human toxicity. Herein, we show that seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4eef26c03fe2af08bc0da4e7f4d1318

Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

Autor: Sarah J. Parker, Juan F. Calderón, Christel Van Erp, Djahida Bedja, Loretha Myers, David C. Loch, Rosanne Rouf, Russell A. Norris, Harry C. Dietz, Sara K. Cooke, Daniel P. Judge, Mark E. Lindsay, Elizabeth E. Gerber, David L. Huso, Elena M. Gallo, Colette M. Ap Rhys, Yichun Chen, Jennifer P Habashi, Kathleen C. Kent, Kimberly Sauls

Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan syndrome. LDS is caused by heterozygous missense mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96f9ec04a707eb11e3f353d112545b4
https://europepmc.org/articles/PMC3871227/

Contributors

Autor: Russell C. Addis, Jon D. Ahlstrom, Michal Amit, Peter W. Andrews, Joyce Axelman, M. Azim Surani, Nissim Benvenisty, Mickie Bhatia, Ali H. Brivanlou, Joseph W. Carnwath, Melissa K. Carpenter, Howard Y. Chang, Xin Chen, Tao Cheng, Susana M. Chuva de Sousa Lopes, Gregory O. Clark, Joshua D. Dowell, Jonathan S. Draper, Martin Evans, Loren J. Field, Margaret T. Fuller, Richard L. Gardner, Svetlana Gavrilov, John D. Gearhart, Charles A. Gersbach, Marko E. Horb, Joseph Itskovitz-Eldor, Junfeng Ji, Penny Johnson, D. Leanne Jones, Kathleen C. Kent, Candace L. Kerr, Ali Khademhosseini, Irina Klimanskaya, Jennifer N. Kraszewski, Wilfried A. Kues, Donald W. Landry, Robert Langer, Shulamit Levenberg, John W. Littlefield, Andrea Lucas-Hahn, Anne McLaren, Jill McMahon, M. Martins-Green, Yoav Mayshar, Douglas Melton, Christine L. Mummery, Andras Nagy, Heiner Niemann, Shin-Ichi Nishikawa, Hitoshi Niwa, Keisuke Okita, Virginia E. Papaioannou, Ethan S. Patterson, Alice Pébay, Martin F. Pera, M. Petreaca, Emily N. Price, Jane Rossant, Michael Rubart, David T. Scadden, Thomas Schulz, Michael J. Shamblott, Harvir Singh, David L. Stocum, James A. Thomson, David Tosh, Alan Trounson, Chunhui Xu, Kohei Yamamizu, Shinya Yamanaka, Jun K. Yamashita, Holly Young, Bonan Zhong, Leonard I. Zon, Thomas P. Zwaka, Robert Zweigerdt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::329cf269010ada18af8f4bc14c1c4090
https://doi.org/10.1016/b978-0-12-385942-6.01003-9

Familial thoracic aortic dilation and bicommissural aortic valve: a prospective analysis of natural history and inheritance

Autor: Melissa L. Loscalzo, Bart Loeys, Philip J. Spevak, Harry C. Dietz, Kathleen C. Kent, Denise L.M. Goh

Publikováno v: American journal of medical genetics. Part A. (17)

The autosomal dominant inheritance of bicommissural aortic valve (BAV) (Online Mendelian Inheritance in Man #109730) in some families is well-documented; however, the inheritance of BAV with thoracic aortic aneurysm (TAA) is less clear. Whether the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27053c1630828cef82e94017aadb0e3
https://pubmed.ncbi.nlm.nih.gov/17676603

Contributors

Autor: Russell C. Addis, Bruce Alberts, Michal Amit, Peter W. Andrews, Hitomi Aoki, Makoto Asashima, Joyce Axelman, Daniel Becker, Nissim Benvenisty, Mickie Bhatia, C. Clare Blackburn, Michele Boiani, Susan Bonner-Weir, Josephine Bowles, Richard L. Boyd, Marianne Bronner-Fraser, Eric W. Brunskill, Scott Bultman, Frederick Charles Campbell, Anne Camus, Melissa K. Carpenter, Fatima Cavaleri, Constance Cepko, Yijing Chen, Susana M. Chuva de Sousa Lopes, Gregory O. Clark, Jérôme Collignon, Paul Collodi, Chad Cowan, George Q. Daley, Christian Dani, Joshua D. Dowell, Jonathan S. Draper, Gregory R. Dressler, Micha Drukker, Gabriela Durcova-Hills, Robert G. Edwards, Rebecca S. Eisenberg, Ravindhra Elluru, Sir Martin Evans, Lianchun Fan, Margaret A. Farley, Donna M. Fekete, Loren J. Field, Donald W. Fink, Lesley M. Forrester, Margaret T. Fuller, Miho Furue, David L. Garbers, Richard L. Gardner, John D. Gearhart, Sharon Gerecht-Nir, Jason W. Gill, Rodolfo Gonzalez, Daniel H.D. Gray, Ronald M. Green, Michal Gropp, Alexandra Haagensen, F. Kent Hamra, Richard P. Harvey, Susan M. Hawes, Shin-Ichi Hayashi, Anne L. Hazlehurst, Hiroaki Hemmi, Hiroshi Hisatsune, James Huettner, Bradley Huntsman, Catherine Iéhlé, Jamie Imitola, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Penny A. Johnson, D. Leanne Jones, Elizabeth A. Jones, Gerard Karsenty, Gil Katz, Pritinder Kaur, Robert G. Kelly, Kathleen C. Kent, Candace L. Kerr, Ali Khademhosseini, Hanita Khaner, Chris Kintner, Irina Klimanskaya, Nobuyuki Kondoh, Peter Koopman, Naoko Koyano-Nakagawa, Jennifer N. Kraszewski, Robb Krumlauf, Tilo Kunath, Takahiro Kunisada, Robert Langer, Robert Lanza, Jean Pyo Lee, Shulamit Levenberg, S. Robert Levine, Haifan Lin, John W. Littlefield, Michael J. Lysaght, Fiona A. Mack, Terry Magnuson, Anna Malashicheva, Ofer Mandelboim, Nancy R. Manley, Klaus I. Matthaei, Yoav Mayshar, John W. McDonald, Dame Anne McLaren, Jill McMahon, Alexander Meissner, Harald von Melchner, Douglas A. Melton, Nathan Montgomery, Mary Tyler Moore, Tsutomu Motohashi, Franz-Josef Mueller, Christine Mummery, Satomi Nishikawa, Shin-Ichi Nishikawa, Andras Nagy, Hitoshi Niwa, Hiromi Okuyama, Jitka Ourednik, Vaclav Ourednik, Masahito Oyamada, Yumiko Oyamada, Virginia E. Papaioannou, Kook I. Park, Ethan S. Patterson, Larry T. Patterson, Alice Pébay, Martin F. Pera, Aitana Perea-Gomez, Anthony C.F. Perry, James N. Petitte, Blaine W. Phillips, S. Steven Potter, Arti K. Rai, Christopher Reeve, Benjamin Reubinoff, Janet Rossant, Michael Rubart, Pierre Savatier, Hans Schöler, Cordula Schulz, Nikolaus Schultz, Michael J. Shamblott, Richard L. Sidman, M. Celeste Simon, Evan Y. Snyder, A. Francis Stewart, Lorenz Studer, Azim Surani, Tetsuro Takamatsu, Yang D. Teng, Irma Thesleff, James A. Thomson, David Tosh, Paul Trainor, Alan O. Trounson, Motokazu Tsuneto, Mark Tummers, Edward Upjohn, George Varigos, Cécile Vernochet, Jay L. Vivian, Zhongde Wang, Gordon C. Weir, Susan E. Wert, Jeffrey A. Whitsett, J. David Wininger, Zhuoru Wu, Chunhui Xu, Toshiyuki Yamane, Jun Yamashita, Yukiko M. Yamashita, Hidetoshi Yamazaki, Laurie Zoloth, Thomas P. Zwaka, Robert Zweigerdt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5bc76f68389b95a274f8f5574cc9b15
https://doi.org/10.1016/b978-012436643-5/50000-6