Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study

Autor: Kathleen C. Schmidt, Inna Loutaev, Zenaide Quezado, Carrie Sheeler, Carolyn Beebe Smith

Publikováno v: Neurobiology of Disease, Vol 143, Iss , Pp 104978- (2020)

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein (FMRP), a putative translation suppressor, is absent or significantly reduced in FXS. One prevailing hypothesis is that rates

Externí odkaz: https://doaj.org/article/607311faf2cf4cb7a573b2072f003399

Decreased rates of cerebral protein synthesis in conscious young adults with fragile X syndrome demonstrated by L-[1

Autor: Kathleen C, Schmidt, Inna, Loutaev, Thomas V, Burlin, Audrey, Thurm, Carrie, Sheeler, Carolyn Beebe, Smith

Publikováno v: J Cereb Blood Flow Metab

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein, a putative translation suppressor, is significantly reduced in FXS. The prevailing hypothesis is that rates of cerebral prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4ef634f2d5813ae77e6c7e3f91f8c45
https://pubmed.ncbi.nlm.nih.gov/35350914

Regional rates of brain protein synthesis are unaltered in dexmedetomidine sedated young men with fragile X syndrome: A L-[1-11C]leucine PET study

Autor: Carrie Sheeler, Kathleen C Schmidt, Carolyn Beebe Smith, Zenaide M.N. Quezado, Inna Loutaev

Publikováno v: Neurobiology of disease
Neurobiology of Disease, Vol 143, Iss, Pp 104978-(2020)

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. Fragile X mental retardation protein (FMRP), a putative translation suppressor, is absent or significantly reduced in FXS. One prevailing hypothesis is that rates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad14090211fc93a75402aaefe0c5761
https://doi.org/10.1016/j.nbd.2020.104978

Impact of tissue kinetic heterogeneity on PET quantification: Case study with the L-[1-11C]leucine PET method for cerebral protein synthesis rates

Autor: Giampaolo Tomasi, Kathleen C Schmidt, Mattia Veronese, Alessandra Bertoldo, Carolyn Beebe Smith

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Veronese, M, Bertoldo, A, Tomasi, G, Smith, C B & Schmidt, K C 2018, ' Impact of tissue kinetic heterogeneity on PET quantification : case study with the L-[1-11C]leucine PET method for cerebral protein synthesis rates ', Scientific Reports, vol. 8, no. 1 . https://doi.org/10.1038/s41598-017-18890-x
Scientific Reports

Functional quantification with PET is generally based on modeling that assumes tissue regions are kinetically homogeneous. Even in regions sufficiently small to approach homogeneity, spillover due to resolution limitations of PET scanners may introdu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ab7dec6a10209a1bf73e0d48e981b4
http://hdl.handle.net/11577/3262683

Use of Spectral Analysis with Iterative Filter for Voxelwise Determination of Regional Rates of Cerebral Protein Synthesis with L-[1-11C]leucine PET

Autor: Kathleen C Schmidt, Mattia Veronese, Alessandra Bertoldo, Carolyn Beebe Smith

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 32:1073-1085

A spectral analysis approach was used to estimate kinetic parameters of the L-[1-11C]leucine positron emission tomography (PET) method and regional rates of cerebral protein synthesis ( rCPS) on a voxel-by-voxel basis. Spectral analysis applies to bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e1bb94c7d3e2ff0e69fb1b57824fc7
https://doi.org/10.1038/jcbfm.2012.27