Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathleen Bridges"'
Publikováno v:
Ecological Indicators, Vol 168, Iss , Pp 112759- (2024)
Drought is a prolonged dry period that can have severe impacts on the environment, human health, economies, agriculture, and energy resources. It can lead to water shortages, ruin crops, dry out forests, and reduce the availability of food and water
Externí odkaz:
https://doaj.org/article/4bd158b611e145e18488cb9847bd99ab
Autor:
Manish Kumar, David Molkentine, Jessica Molkentine, Kathleen Bridges, Tongxin Xie, Liangpeng Yang, Andrew Hefner, Meng Gao, Reshub Bahri, Annika Dhawan, Mitchell J. Frederick, Sahil Seth, Mohamed Abdelhakiem, Beth M. Beadle, Faye Johnson, Jing Wang, Li Shen, Timothy Heffernan, Aakash Sheth, Robert L. Ferris, Jeffrey N. Myers, Curtis R. Pickering, Heath D. Skinner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in histone acetyltransferases (HATs) CREBBP and EP300 are generally thought to lead to decreased function or absence of protein product. Here the authors describe a gain of function of several CREBBP mutations leading to baseline hyper-acet
Externí odkaz:
https://doaj.org/article/9e9b057abf944363949c648ff88a38f3
Autor:
Phillip M. Pifer, Vlad C. Sandulache, Kathryn A. Mason, Manish Kumar, Liang Yang, Jessica M. Molkentine, Howard D. Thames, Beth M. Beadle, Aakash Sheth, David Molkentine, David Valdecanas, Rishi Bahri, Mohamed Abdelhakiem, Heath D. Skinner, Andrew J. Hefner, Curtis R. Pickering, Kathleen Bridges, Raymond E. Meyn
Squamous cell carcinoma driven by human papillomavirus (HPV) is more sensitive to DNA-damaging therapies, such as radiation, than its HPV-negative counterpart. Here we show that p16, the clinically utilized surrogate for HPV positivity, renders cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a49088ee08ac0d95d5c3addeff6569fc
https://doi.org/10.21203/rs.3.rs-130839/v3
https://doi.org/10.21203/rs.3.rs-130839/v3
Autor:
Liang Yang, Raymond E. Meyn, Phillip M. Pifer, Rishi Bahri, Kathryn A. Mason, Jessica M. Molkentine, Howard D. Thames, Heath D. Skinner, Curtis R. Pickering, Mohamed Abdelhakiem, Beth M. Beadle, Andrew J. Hefner, Kathleen Bridges, Manish Kumar, Aakash Sheth, David Valdecanas, Vlad C. Sandulache, David Molkentine
Human papillomavirus (HPV) drives the development of squamous cell carcinoma at several sites, including the oropharynx. Generally, the presence of HPV renders a tumor more sensitive to DNA-damaging therapies such as radiation; however, the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4166147183bcbc0857306ed091b01c5
https://doi.org/10.21203/rs.3.rs-130839/v1
https://doi.org/10.21203/rs.3.rs-130839/v1
Autor:
Reshub Bahri, Annika Dhawan, Liangpeng Yang, Li Shen, Jessica M. Molkentine, Andrew J. Hefner, Jing Wang, Robert L. Ferris, Beth M. Beadle, Meng Gao, Kathleen Bridges, Mohamed Abdelhakiem, Aakash Sheth, Manish Kumar, Sahil Seth, Heath D Skinner, Faye M. Johnson, Jeffrey N. Myers, Curtis R. Pickering, Timothy P. Heffernan, Tongxin Xie, David Molkentine, Mitchell J. Frederick
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiosensitizers for clinical use. Herein we perform in vivo shRNA screening to identify targets generally associated with radiation response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d0fbc54e6849ef9f4b8260ed195d92
https://pubmed.ncbi.nlm.nih.gov/34732714
https://pubmed.ncbi.nlm.nih.gov/34732714
Autor:
Liang Yang, Jing Wang, Jessica M. Molkentine, Robert L. Ferris, Timothy P. Heffernan, Faye M. Johnson, Meng Gao, Aakash Sheth, Heath D. Skinner, Curtis R. Pickering, Sahil Seth, Mohamed Abdelhakiem, Manish Kumar, Li Shen, Andrew J. Hefner, Kathleen Bridges, Mitchell J. Frederick, Tongxin Xie, David Molkentine, Jeffrey N. Myers, Beth M. Beadle
Despite radiation forming the curative backbone of over 50% of malignancies, there are no genomically-driven radiation sensitizers for clinical use. We performedin vivoshRNA screening to identify targets generally associated with radiation response a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db543fb8f1a8b13d4c8290647d1629b2
https://doi.org/10.1101/2020.04.10.028217
https://doi.org/10.1101/2020.04.10.028217
Autor:
Alma Z. Faust, Heath D. Skinner, Tongxin Xie, Curtis R. Pickering, Liangpeng Yang, Raymond E. Meyn, David A. Clump, Robert L. Ferris, Aakash Sheth, David Molkentine, Mitchell J. Frederick, Jessica M. Molkentine, Jeffrey N. Myers, Kathleen Bridges, Timothy P. Heffernan, Kathryn A. Mason
Publikováno v:
Int J Radiat Biol
PURPOSE: Head and neck cancers (HNSCC) are routinely treated with radiotherapy; however normal tissue toxicity remains a concern. Therefore, it is important to validate treatment modalities combining molecularly targeted agents with radiotherapy to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff633cb3ef17fd2894f31784b90ba11
https://europepmc.org/articles/PMC7483862/
https://europepmc.org/articles/PMC7483862/
Autor:
Crosby D. Rock, Raymond E. Meyn, Heath D. Skinner, Xingxing Chen, Thomas A. Buchholz, Stuart D. Shumway, Kathleen Bridges, Huifeng Liu
Publikováno v:
Oncotarget
Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase inhibitor, MK-8776, for its ability to radiosensitize human tumor cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb10f60c23deb66f99cb5ea56c3ac9b
https://doi.org/10.18632/oncotarget.12311
https://doi.org/10.18632/oncotarget.12311
Autor:
Carlo Toniatti, Carolyn A. Buser, Kathleen Bridges, Raymond E. Meyn, Huifeng Liu, Thomas A. Buchholz
Publikováno v:
Oncotarget
// Kathleen A. Bridges 1 , Carlo Toniatti 2 , Carolyn A. Buser 3 , Huifeng Liu 1 , Thomas A. Buchholz 4 , and Raymond E. Meyn 1 1 Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 2 IRBM/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbfd3a8f1b823267419e77bebb3b9c4
https://doi.org/10.18632/oncotarget.2083
https://doi.org/10.18632/oncotarget.2083