Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Kathleen Aertgeerts"'
Autor:
Thao T. Ho, Jasmine T. Nguyen, Juping Liu, Pawel Stanczak, Aaron A. Thompson, Yingzhuo G. Yan, Jasmine Chen, Charles K. Allerston, Charles L. Dillard, Hao Xu, Nicholas J. Shoger, Jill S. Cameron, Mark E. Massari, Kathleen Aertgeerts
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 603-607 (2017)
Galanin Receptor 3 (GALR3) is a G-protein-coupled receptor with a widespread distribution in the brain and plays a role in a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior
Externí odkaz:
https://doaj.org/article/75527cfda4c84f24806d95423f249dc0
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2507
Overexpression of biologically functional GPCRs and homogeneous purified protein solutions are required to enable structural studies and protein-based biophysical assay development. Iterative and time-consuming optimization cycles of protein engineer
Publikováno v:
Methods in Molecular Biology ISBN: 9781071623671
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def3e2d3f4bda4f1f749bd71d1f6e249
https://doi.org/10.1007/978-1-0716-2368-8_17
https://doi.org/10.1007/978-1-0716-2368-8_17
Autor:
Yingzhuo Yan, Guibao Gu, J. A. Vivian, Adia Zhang, Ali Tabatabaei, Laurent Gomez, Yu-wen Li, J. Guy Breitenbucher, Kathleen Aertgeerts, Hao Xu, Anne Danks, Eben Massari, Andrew Morse, Noelle Warren, Trevor Scott
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 370:399-407
Inhibition of phosphodiesterase 2A (PDE2A) has been proposed as a potential approach to enhance cognitive functioning and memory through boosting intracellular cGMP/cAMP and enhancing neuroplasticity in memory-related neural circuitry. Previous precl
Autor:
Kiev S. Ly, Laurent Gomez, Mark Eben Massari, Markus Metz, Rui Xu, Tami Jo Marrone, W. Sinko, J.G. Breitenbucher, B. Appleton, R. Truong, B. Selfridge, Kathleen Aertgeerts, William F. Vernier, Yingzhuo Yan, Kristen Sebring
Publikováno v:
Journal of Medicinal Chemistry. 61:7754-7766
In medicinal chemistry, accurate prediction of additivity-based structure-activity relationship (SAR) analysis rests on three assumptions: (1) a consistent binding pose of the central scaffold, (2) no interaction between the R group substituents, and
Autor:
Hao Xu, Aaron Thompson, Kathleen Aertgeerts, Charles L. Dillard, Jill S. Cameron, Pawel Stanczak, Jasmine T. Nguyen, Charles K. Allerston, Juping Liu, Yingzhuo G. Yan, Jasmine Chen, Thao T. Ho, Nicholas J. Shoger, Mark Eben Massari
Publikováno v:
Data in Brief
Data in Brief, Vol 12, Iss C, Pp 603-607 (2017)
Data in Brief, Vol 12, Iss C, Pp 603-607 (2017)
Galanin Receptor 3 (GALR3) is a G-protein-coupled receptor with a widespread distribution in the brain and plays a role in a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior
Autor:
Margaret McCarrick, Richard Barido, Troy Vickers, Ali Tabatabaei, J. Guy Breitenbucher, Mark Eben Massari, Robert Lemus, Laurent Gomez, Marco Peters, Markus Metz, Rui Xu, Xianbo Zhou, David Neul, William F. Vernier, Nicola J. Broadbent, Yingzhou G. Yan, Graeme Freestone, Kathleen Aertgeerts, Zachary W. Yoder, Noelle Warren, Carsten B. Andersen, Kara Schmelzer, Kristen Sebring, Kiev S. Ly, Tami Jo Marrone, Dong Lee
Publikováno v:
Journal of medicinal chemistry. 60(5)
A series of potent and selective [1,2,4]triazolo[1,5-a]pyrimidine PDE2a inhibitors is reported. The design and improvement of the binding properties of this series was achieved using X-ray crystal structures in conjunction with careful analysis of el
Autor:
Weston Lane, Franz Gruswitz, Yoshihiko Hirozane, Ankita Srivastava, Kathleen Aertgeerts, Kengo Okada, Andrew John Jennings, Jason Yano, Gyorgy Snell, Georgia Kefala, Jasmine T. Nguyen, Anthony Ivetac
Publikováno v:
Nature. 513:124-127
The X-ray crystal structure of human GPR40 receptor in the presence of TAK-875, an orally available, potent and selective human GPR40 agonist. The G-protein-coupled receptor (GPCR) human GPR40 (hGPR40, also known as free fatty-acid receptor 1) is an
Autor:
Nicholas J. Shoger, Charles K. Allerston, Charles L. Dillard, Yingzhuo G. Yan, Jasmine Chen, Juping Liu, Pawel Stanczak, Thao T. Ho, Hao Xu, Mark Eben Massari, Jasmine T. Nguyen, Jill S. Cameron, Aaron Thompson, Kathleen Aertgeerts
Publikováno v:
Protein expression and purification. 133
Recent innovative approaches to stabilize and crystallize GPCRs have resulted in an unprecedented breakthrough in GPCR crystal structures as well as application of the purified receptor protein in biophysical and biochemical ligand binding assays. Ho
Autor:
Oliver S. Smart, Paul Emsley, Cary B. Bauer, David A. Case, John L. Markley, Joseph Marcotrigiano, Jasmine Young, Atsushi Nakagawa, Seth F. Harris, Haruki Nakamura, Wolfram Tempel, Radka Svobodová, T. Krojer, Pamela A. Williams, Robert T. Nolte, Catherine E. Peishoff, Jorg Hendle, Chenghua Shao, Jeff Blaney, Dale E. Tronrud, Paul D. Adams, Randy J. Read, Marc C. Nicklaus, Kirk Clark, Helen M. Berman, Jeffrey A. Bell, Evan E Bolton, Suzanna C. Ward, Stephen K. Burley, Alan E. Mark, Garib N. Murshudov, Victoria A. Feher, Matthew T. Miller, John Spurlino, Sameer Velankar, Steven Sheriff, Tom Darden, Wladek Minor, Talapady N. Bhat, John D. Westbrook, Gerard J. Kleywegt, Terry R. Stouch, Huanwang Yang, Gérard Bricogne, Thomas C. Terwilliger, Anil K. Padyana, Zukang Feng, Colin R. Groom, Andrzej Joachimiak, David G. Brown, Anthony Nicholls, Gaetano T. Montelione, Thomas Holder, Kathleen Aertgeerts, Stephen M. Soisson, Gregory L. Warren, Susan Pieniazek
Publikováno v:
Structure (London, England : 1993), vol 24, iss 4
Adams, PD; Aertgeerts, K; Bauer, C; Bell, JA; Berman, HM; Bhat, TN; et al.(2016). Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24(4), 502-508. doi: 10.1016/j.str.2016.02.017. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/42h5d920
Adams, PD; Aertgeerts, K; Bauer, C; Bell, JA; Berman, HM; Bhat, TN; et al.(2016). Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24(4), 502-508. doi: 10.1016/j.str.2016.02.017. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/42h5d920
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent\ud an important source of information concerning drug-target interactions, providing atomic level insights\ud into the physical chemistry of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fa7fc51624930579bc888e19578253
https://www.repository.cam.ac.uk/handle/1810/254110
https://www.repository.cam.ac.uk/handle/1810/254110