Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kathleen A. Trychta"'
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The lumen of the endoplasmic reticulum (ER) has resident proteins that are critical to perform the various tasks of the ER such as protein maturation and lipid metabolism. These ER resident proteins typically have a carboxy-terminal ER retention/retr
Externí odkaz:
https://doaj.org/article/055b9f5b3e3d4131b3297496d14b375d
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1829-1840.e6 (2018)
Summary: Retention of critical endoplasmic reticulum (ER) luminal proteins needed to carry out diverse functions (e.g., protein synthesis and folding, lipid metabolism) is mediated through a carboxy-terminal ER retention sequence (ERS) and its intera
Externí odkaz:
https://doaj.org/article/aa01718337ef4e73aafa887623435c3a
Autor:
Reinis Svarcbahs, Sarah M. Blossom, Helena S. Baffoe-Bonnie, Kathleen A. Trychta, Lacey K. Greer, James Pickel, Mark J. Henderson, Brandon K. Harvey
Publikováno v:
Transgenic Research. 32:209-221
Maintenance of calcium homeostasis is important for proper endoplasmic reticulum (ER) function. When cellular stress conditions deplete the high concentration of calcium in the ER, ER-resident proteins are secreted into the extracellular space in a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacd76a61397ae3f5d3d7c9b7ffc2836
https://doi.org/10.1007/s11248-023-00349-7
https://doi.org/10.1007/s11248-023-00349-7
Autor:
Kathleen A. Trychta, Brandon K. Harvey
Publikováno v:
Multidisciplinary Digital Publishing Institute
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ORCID
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 1974
UnpayWall
ORCID
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 1974
Drugs of abuse can cause local and systemic hyperthermia, a known trigger of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). Another trigger of ER stress and UPR is ER calcium depletion which causes ER exodosis, the secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464cf372f42599241485e7cdac534cea
https://doi.org/10.3390/ijms23041974
https://doi.org/10.3390/ijms23041974
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 9 (2021)
Frontiers in Chemistry, Vol 9 (2021)
The lumen of the endoplasmic reticulum (ER) has resident proteins that are critical to perform the various tasks of the ER such as protein maturation and lipid metabolism. These ER resident proteins typically have a carboxy-terminal ER retention/retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15676e694d51cb103d1f86182059e691
https://doi.org/10.3389/fchem.2021.689608
https://doi.org/10.3389/fchem.2021.689608
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5436, p 5436 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
The KDEL receptor retrieval pathway is essential for maintaining resident proteins in the endoplasmic reticulum (ER) lumen. ER resident proteins serve a variety of functions, including protein folding and maturation. Perturbations to the lumenal ER m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9aba5cd426942524e544dfcabaa9d1d
https://www.mdpi.com/1422-0067/22/11/5436
https://www.mdpi.com/1422-0067/22/11/5436
Autor:
Fumihiko Urano, Alexey V. Zakharov, Xiaokang Yan, Adam Yasgar, David G. Maloney, Kuo Jen Wu, Susanne Bäck, Xin Hu, Dingyin Tao, Xin Xu, Ganesha Rai, Hideaki Yano, Oksana Gavrilova, Carina Danchik, Brandon K. Harvey, Ajit Jadhav, Mikko Airavaara, Shyh Ming Yang, Anton Simeonov, Amy Wang, Mark J. Henderson, Kathleen A. Trychta, Yun Wang, Gergely Zahoránszky-Kőhalmi, Lei Shi, Emily S. Wires
Publikováno v:
Cell Rep
Endoplasmic reticulum (ER) dysregulation is associated with pathologies including neurodegenerative, muscular, and diabetic conditions. Depletion of ER calcium can lead to the loss of resident proteins in a process termed exodosis. To identify compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533304cff990505d799ec3e79ecffb6b
https://europepmc.org/articles/PMC8545458/
https://europepmc.org/articles/PMC8545458/
The lumen of the endoplasmic reticulum (ER) has resident proteins that are critical to perform the various tasks of the ER such as protein maturation and lipid metabolism. These ER resident proteins typically have a carboxy-terminal ER retention sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e467a54a8c540fa9258c6eef226c0b
https://doi.org/10.1101/2021.03.21.435734
https://doi.org/10.1101/2021.03.21.435734
Autor:
Kenner C. Rice, Emily J. Heathward, Lorenzo Leggio, Christopher T. Richie, Kathleen A. Trychta, Agnieszka Sulima, Brandon K. Harvey, Susanne Bäck, Mehdi Farokhnia
Publikováno v:
Biomarkers. 23:756-765
CONTEXT: Endoplasmic reticulum (ER) calcium depletion is associated with diverse diseases, including cardiac, hepatic and neurologic diseases. OBJECTIVE: The aim of the present study was to identify and characterize an endogenous protein that could b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3fe2b89a3bb43a8bb2de16dfffc958
https://doi.org/10.1080/1354750x.2018.1490968
https://doi.org/10.1080/1354750x.2018.1490968
Autor:
Mark J. Henderson, Emily S. Wires, Christopher T. Richie, Kathleen A. Trychta, Brandon K. Harvey
Publikováno v:
Molecular Biology of the Cell
Depletion of ER calcium can lead to cell death and is implicated in numerous diseases. Secreted ER calcium-monitoring proteins (SERCaMPs) are secreted in response to ER calcium depletion. SERCaMPs identified ER calcium depletion in primary neurons ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94768b4e43db262d889eb7cf3ecd649f
https://doi.org/10.1091/mbc.e14-06-1141
https://doi.org/10.1091/mbc.e14-06-1141