Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Kathleen A. O'Leary"'
Autor:
Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris, Linda A. Schuler
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infilt
Externí odkaz:
https://doaj.org/article/ed62145c75cf435aa09efab35a43623c
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment fo
Externí odkaz:
https://doaj.org/article/5182a8b990d848bdaa69308ac2077051
Autor:
Linda A. Schuler, Kathleen A. O’Leary
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Prolactin coordinates with the ovarian steroids to orchestrate mammary development and lactation, culminating in nourishment and an increasingly appreciated array of other benefits for neonates. Its central activities in mammary epithelial growth and
Externí odkaz:
https://doaj.org/article/890c152d12da4a31b35ed89c0806b80e
Autor:
Kathleen A. O'Leary, Michael P. Shea, Stephanie Salituro, Courtney E. Blohm, Linda A. Schuler
Publikováno v:
Stem Cell Reports, Vol 9, Iss 4, Pp 1167-1179 (2017)
Hormones drive mammary development and function and play critical roles in breast cancer. Epidemiologic studies link prolactin (PRL) to increased risk for aggressive cancers that express estrogen receptor α (ERα). However, in contrast to ovarian st
Externí odkaz:
https://doaj.org/article/71a50e29243b4b40beb7917e2dbc3d90
Autor:
Linda A. Schuler, Caroline M. Alexander, Kari B. Wisinski, Andreas Friedl, Vincent Goffin, Saja A. Fakhraldeen, Kathleen A. O'Leary, Michael P. Shea
Supplemental Tables 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a528479488284c5962d2cd068ae4e0e8
https://doi.org/10.1158/0008-5472.22417473.v1
https://doi.org/10.1158/0008-5472.22417473.v1
Autor:
Linda A. Schuler, Caroline M. Alexander, Kari B. Wisinski, Andreas Friedl, Vincent Goffin, Saja A. Fakhraldeen, Kathleen A. O'Leary, Michael P. Shea
This file contains additional technical detail (antibodies used, gating strategy for FACS) and additional experimental data to complement that shown in the main figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7daad44b16300298a01e28c05aeffd
https://doi.org/10.1158/0008-5472.22417476.v1
https://doi.org/10.1158/0008-5472.22417476.v1
Autor:
Linda A. Schuler, Caroline M. Alexander, Kari B. Wisinski, Andreas Friedl, Vincent Goffin, Saja A. Fakhraldeen, Kathleen A. O'Leary, Michael P. Shea
Although antiestrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα+) breast cancer, 25% to 40% fail to respond. Although multiple mechanisms underlie evasion of these treatments, including tumor heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b44379cf0495053845583fdfbf888e
https://doi.org/10.1158/0008-5472.c.6509853.v1
https://doi.org/10.1158/0008-5472.c.6509853.v1
Autor:
Ying Zhang, Raghava N. Sriramaneni, Paul A. Clark, Justin C. Jagodinsky, Mingzhou Ye, Wonjong Jin, Yuyuan Wang, Amber Bates, Caroline P. Kerr, Trang Le, Raad Allawi, Xiuxiu Wang, Ruosen Xie, Thomas C. Havighurst, Ishan Chakravarty, Alexander L. Rakhmilevich, Kathleen A. O’Leary, Linda A. Schuler, Paul M. Sondel, Kyungmann Kim, Shaoqin Gong, Zachary S. Morris
Publikováno v:
Nature communications. 13(1)
Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize tumor antigen presentation or fully overcome suppressive mechanisms in t
Autor:
Jennifer L. Matucha, Bradford Bopp, Matthew Will, Erica Anspach Will, Kathleen M. O'Leary, Glen Adaniya
Publikováno v:
Fertility and Sterility. 118:e139
Autor:
Debra E. Rugowski, Jorge F Guerrero, Suzanne M. Ponik, Fatou Jallow, Linda A. Schuler, Kathleen A. O'Leary
Publikováno v:
Oncogene
Metastatic, anti-estrogen resistant estrogen receptor α positive (ER+) breast cancer is the leading cause of breast cancer deaths in U.S. women. While studies have demonstrated the importance of the stromal tumor microenvironment in cancer progressi