Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kathleen A. Hershberger"'
Autor:
Zachary R. Markovich, Jessica H. Hartman, Ian T. Ryde, Kathleen A. Hershberger, Abigail S. Joyce, Patrick L. Ferguson, Joel N. Meyer
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100084- (2022)
Aims: Mitochondrial dysfunction is implicated in several diseases, including neurological disorders such as Parkinson’s disease. However, there is uncertainty about which of the many mechanisms by which mitochondrial function can be disrupted may l
Externí odkaz:
https://doaj.org/article/af65153e866440f4a28635d49c513a85
Autor:
Kathleen A. Hershberger, John P. Rooney, Elena A. Turner, Lauren J. Donoghue, Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, Jina J. Kim, Rashmi Joglekar, Jonathan D. Hibshman, Latasha L. Smith, Dhaval P. Bhatt, Olga R. Ilkayeva, Matthew D. Hirschey, Joel N. Meyer
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 102000- (2021)
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria.
Externí odkaz:
https://doaj.org/article/b4cfc3d8ec28428e988509c328dc431a
Autor:
Tess C Leuthner, Laura Benzing, Brendan F Kohrn, Christina M Bergemann, Michael J Hipp, Kathleen A Hershberger, Danielle F Mello, Tymofii Sokolskyi, Kevin Stevenson, Ilaria R Merutka, Sarah A Seay, Simon G Gregory, Scott R Kennedy, Joel N Meyer
Publikováno v:
Nucleic acids research. 50(15)
Mitochondrial DNA (mtDNA) is prone to mutation in aging and over evolutionary time, yet the processes that regulate the accumulation of de novo mtDNA mutations and modulate mtDNA heteroplasmy are not fully elucidated. Mitochondria lack certain DNA re
Autor:
Tess C Leuthner, Laura Benzing, Brendan F Kohrn, Christina M Bergemann, Michael J Hipp, Kathleen A Hershberger, Danielle F Mello, Tymofii Sokolskyi, Ilaria R Merutka, Sarah A Seay, Scott R Kennedy, Joel N Meyer
Mitochondrial DNA (mtDNA) is prone to mutation in aging and over evolutionary time, yet the processes that regulate the accumulation of de novo mtDNA mutations and modulate mtDNA heteroplasmy are not fully elucidated. Mitochondria lack certain DNA re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::600b6971059570e78d4cbd9fa22f5bad
https://doi.org/10.1101/2022.03.28.486090
https://doi.org/10.1101/2022.03.28.486090
Autor:
Ian T. Ryde, Latasha L. Smith, Olga Ilkayeva, John P. Rooney, Kathleen A. Hershberger, Jonathan D. Hibshman, Laura L. Maurer, Lauren J. Donoghue, Matthew D. Hirschey, Joel N. Meyer, Elena A. Turner, Jina J. Kim, Dhaval P. Bhatt, Rakesh Bodhicharla, Rashmi Joglekar
Publikováno v:
Redox Biology, Vol 43, Iss, Pp 102000-(2021)
Redox Biology
Redox Biology
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage resulting from some genotoxicants than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria.
Autor:
Matthew A Schechter, Michael K H Hsieh, Linda W Njoroge, J Will Thompson, Erik J Soderblom, Bryan J Feger, Constantine D Troupes, Kathleen A Hershberger, Olga R Ilkayeva, Whitney L Nagel, Gina P Landinez, Kishan M Shah, Virginia A Burns, Lucia Santacruz, Matthew D Hirschey, Matthew W Foster, Carmelo A Milano, M Arthur Moseley, Valentino Piacentino, Dawn E Bowles
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104157 (2014)
The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development of more effective hear
Externí odkaz:
https://doaj.org/article/97d4172e41884dda9d397f4cdd8030bd
Autor:
Jina J. Kim, Ian T. Ryde, Latasha L. Smith, Elena A. Turner, Jonathan D. Hibshman, Matthew D. Hirschey, Joel N. Meyer, Laura L. Maurer, Kathleen A. Hershberger, Dhaval P. Bhatt, Olga Ilkayeva, John P. Rooney, Rashmi Joglekar, Lauren J. Donoghue
The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c678a96776edeae2b673b37b9cbba8c
https://doi.org/10.1101/2020.11.25.398164
https://doi.org/10.1101/2020.11.25.398164
Autor:
Juan Liu, Jason W. Locasale, Kathleen A. Hershberger, Paul A. Grimsrud, Dennis M. Abraham, Matthew D. Hirschey
Publikováno v:
Journal of Biological Chemistry. 293:10630-10645
Mitochondrial Sirtuin 5 (SIRT5) is an NAD+-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac func
Publikováno v:
Nature Reviews Nephrology. 13:213-225
The coenzyme nicotinamide adenine dinucleotide (NAD+) has key roles in the regulation of redox status and energy metabolism. NAD+ depletion is emerging as a major contributor to the pathogenesis of cardiac and renal diseases and NAD+ repletion strate
Autor:
Kathleen A, Hershberger, Dennis M, Abraham, Juan, Liu, Jason W, Locasale, Paul A, Grimsrud, Matthew D, Hirschey
Publikováno v:
The Journal of biological chemistry. 293(27)
Mitochondrial Sirtuin 5 (SIRT5) is an NAD(+)-dependent demalonylase, desuccinylase, and deglutarylase that controls several metabolic pathways. A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac fu