Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kathleen A Messemer"'
Autor:
Sahar Tavakoli, Vivian Garcia, Eric Gähwiler, Isaac Adatto, Apoorva Rangan, Kathleen A. Messemer, Sara Ashrafi Kakhki, Song Yang, Victoria S. Chan, Margot E. Manning, Haleh Fotowat, Yi Zhou, Amy J. Wagers, Leonard I. Zon
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112365- (2023)
Summary: Stem cell transplantation presents a potentially curative strategy for genetic disorders of skeletal muscle, but this approach is limited by the deleterious effects of cell expansion in vitro and consequent poor engraftment efficiency. In an
Externí odkaz:
https://doaj.org/article/e15cef7ae5ba4dcdbf25249bf15ca76b
Autor:
John Lian, Ryan G. Walker, Andrea D’Amico, Ana Vujic, Melanie J. Mills, Kathleen A. Messemer, Kourtney R. Mendello, Jill M. Goldstein, Krystynne A. Leacock, Soraya Epp, Emma V. Stimpfl, Thomas B. Thompson, Amy J. Wagers, Richard T. Lee
Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGFβ family proteins that interact with nearly identical signaling receptors and antagonist proteins. However, GDF11 appears to activate SMAD2/3 in vitro and in vivo more p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563ca82570f048749642e1a55a4bb43d
Autor:
Sahar Tavakoli, Isaac Adatto, Sara Ashrafi Kakhki, Victoria S Chan, Haleh Fotowat, Eric Gähwiler, Margot E Manning, Kathleen A Messemer, Apoorva Rangan, Song Yang, Amy J Wagers, Leonard I Zon
SummaryStem cell transplantation presents a potentially curative strategy for genetic disorders of skeletal muscle, but this approach is limited due to the deleterious effects of cell expansionin vitroand consequent poor engraftment efficiency. In an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9604ab835744f8a3c35188db57f60907
https://doi.org/10.1101/2023.01.13.523942
https://doi.org/10.1101/2023.01.13.523942
Autor:
Samuel J. Wattrus, Miook Cho, Austin Valido, Amy J. Wagers, Kathleen A. Messemer, Paul Besseling, Richard T. Lee, Ryan G. Walker, Melanie J. Mills, Jill M. Goldstein, Kyu Ha Lee, Jordan P. Lewandowski
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports
Scientific Reports
Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf23623c74443ab125114c1e26986909
http://link.springer.com/article/10.1038/s41598-019-54766-y
http://link.springer.com/article/10.1038/s41598-019-54766-y
Autor:
Simona Cristea, Fei Ji, Michael S. Hoetker, Bruno Di Stefano, Ruslan I. Sadreyev, Masakazu Yamamoto, Kathleen A. Messemer, Alexander Meissner, Aaron J. Huebner, Franziska Michor, Masaki Yagi, Naftali Horwitz, Anthony Patelunas, David J. Goldhamer, A. Almada, Nikolaos Tsopoulidis, Konrad Hochedlinger, Jocelyn Charlton, Ori Bar-Nur, Amy J. Wagers
Publikováno v:
Genes Dev
Genes and Development
Genes & Development, 35 (17-18)
Genes and Development
Genes & Development, 35 (17-18)
The generation of myotubes from fibroblasts upon forced MyoD expression is a classic example of transcription factor-induced reprogramming. We recently discovered that additional modulation of signaling pathways with small molecules facilitates repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761430d06c8b0d8285b6cc1b0b333fe2
Autor:
Jeffrey J. Widrick, Alexandra C. Stanton, Behzad Moghadaszadeh, Amy J. Wagers, Naftali Horwitz, Emily C Troiano, Bryan L Peacker, Mohammadsharif Tabebordbar, Emily M King, Krystynne A Leacock, Pardis C. Sabeti, Simon Ye, Sahar Tavakoli, Kim A. Lagerborg, Kathleen A. Messemer, Alan H. Beggs, Liana Tellez, Allison Krunnfusz
Publikováno v:
Cell. 184(19)
Replacing or editing disease-causing mutations holds great promise for treating many human diseases. Yet, delivering therapeutic genetic modifiers to specific cells in vivo has been challenging, particularly in large, anatomically distributed tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e45d7a4abfeb5420171f7106bf4755
https://pubmed.ncbi.nlm.nih.gov/34732902
https://pubmed.ncbi.nlm.nih.gov/34732902
Autor:
Naftali Horwitz, Feodor D. Price, Lee L. Rubin, Amy J. Wagers, Michelle Ko, Özge Vargel Bölükbaşı, Manisha Sinha, Alfredo E. Gonzalez, Sonia Chen, A. Almada, Kathleen A. Messemer
Publikováno v:
Cell reports. 34(4)
Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle. Although SCs have been investigated for nearly 60 years, the molecular drivers that transform quiescent SCs into the rapidly dividing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bc0ddff82ccc052f45d668b6182365
https://pubmed.ncbi.nlm.nih.gov/33503437
https://pubmed.ncbi.nlm.nih.gov/33503437
Autor:
Amy J. Wagers, Jessica C. Garbern, Kathleen A. Messemer, Richard T. Lee, Hilal Sengul, Jill M. Goldstein, Marcos Fernández-Alfara, Amy C. Kristl
Publikováno v:
Blood
Tightly regulated production of mature blood cells is essential for health and survival in vertebrates and dependent on discrete populations of blood-forming (hematopoietic) stem and progenitor cells. Prior studies suggested that inhibition of growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330330af5eb1bb38f38b46de019f5a96
https://pubmed.ncbi.nlm.nih.gov/31530563
https://pubmed.ncbi.nlm.nih.gov/31530563
Autor:
Meryem Gonzalez-Celeiro, Kathleen A. Messemer, Luk H. Vandenberghe, Sara Ashrafi Kakhki, Kexian Zhu, Yulia Shwartz, Jason Cheng, Bryan L Peacker, Charles F. Albright, Ru Xiao, Mohammadsharif Tabebordbar, Trisha Barungi, Leo D. Wang, Jill M. Goldstein, Amy J. Wagers, Ya-Chieh Hsu
Publikováno v:
Cell Reports, 27 (4)
Cell reports
Cell reports
In vivo delivery of genome-modifying enzymes holds significant promise for therapeutic applications and functional genetic screening. Delivery to endogenous tissue stem cells, which provide an enduring source of cell replacement during homeostasis an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483fec36d913b046d7fcd481334ce8f2
https://doi.org/10.1016/j.celrep.2019.03.105
https://doi.org/10.1016/j.celrep.2019.03.105
Autor:
Goldstein, Jill M.1,2,3, Valido, Austin1, Lewandowski, Jordan P.1,2, Walker, Ryan G.1,2, Mills, Melanie J.1,2, Messemer, Kathleen A.1,2,3, Besseling, Paul1,2, Lee, Kyu Ha4, Wattrus, Samuel J.1,2, Cho, Miook1,2,3, Lee, Richard T.1,2, Wagers, Amy J.1,2,3,5 amy_wagers@harvard.edu
Publikováno v:
Scientific Reports. 12/9/2019, Vol. 9 Issue 1, pN.PAG-N.PAG. 1p.