Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Kathleen A Mahon"'
Autor:
Olga Medina-Martinez, Felipe Amaya-Manzanares, Chaomei Liu, Marisela Mendoza, Rina Shah, Li Zhang, Richard R Behringer, Kathleen A Mahon, Milan Jamrich
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4513 (2009)
Rx is a paired-like homeobox gene that is required for vertebrate eye formation. Mice lacking Rx function do not develop eyes or the posterior pituitary. To determine whether Rx is required cell autonomously in these tissues, we generated embryonic c
Externí odkaz:
https://doaj.org/article/e3f78c156f80476487e4408066d06780
Autor:
Milton J. Finegold, Stephen J. Elledge, Kathleen A. Mahon, Michael T. Tetzlaff, Robert J. Schwartz, Mamie Li, Pumin Zhang, Wei Yu, J. Wade Harper
Publikováno v:
Proceedings of the National Academy of Sciences. 101:3338-3345
The mammalian F-box protein Fbw7 and its Caenorhabditis elegans counterpart Sel-10 have been implicated in the ubiquitin-mediated turnover of cyclin E as well as the Notch/Lin-12 family of transcriptional activators. Both unregulated Notch and cyclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a6adf8f47ed3573eaf597035ebef01f
https://doi.org/10.1073/pnas.0307875101
https://doi.org/10.1073/pnas.0307875101
Autor:
Milton J. Finegold, Subrahmanyam S. Chirala, Martin M. Matzuk, Jianqiang Mao, Kathleen A. Mahon, Lutfi Abu-Elheiga, Hua Chang, Salih J. Wakil
Publikováno v:
Proceedings of the National Academy of Sciences. 100:6358-6363
In animals, including humans, the source of long-chain saturated fatty acids is de novo synthesis, which is mediated by fatty acid synthase (FAS), ingested food, or both. To understand the importance of de novo fatty acid synthesis, we generated FAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77efa4e899de14e813e7eb4ff0abdcd7
https://doi.org/10.1073/pnas.0931394100
https://doi.org/10.1073/pnas.0931394100
Autor:
Shioko Kimura, Samuel L. Pfaff, Kamal Sharma, Brigid L.M. Hogan, Kathleen A. Mahon, Naoyuki Takuma, Hui Z. Sheng, Heiner Westphal, Yasuhide Furuta, Jerrold M. Ward
Publikováno v:
Development. 125:4835-4840
Targeted disruption of the homeobox gene T/ebp (Nkx2.1, Ttf1, Titf1) in mice results in ablation of the pituitary. Paradoxically, while T/ebp is expressed in the ventral diencephalon during forebrain formation, it is not expressed in Rathke’s pouch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa8645ec07d042a637ad6f981c3088c
https://doi.org/10.1242/dev.125.23.4835
https://doi.org/10.1242/dev.125.23.4835
Publikováno v:
Mechanisms of Development. 70:25-34
The axial structures, the notochord and the neural tube, play an essential role in the dorsoventral patterning of somites and in the differentiation of their many cell lineages. Here, we investigated the role of the axial structures in the mediolater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f422b38be94ae0b7a1811b0137a11f63
https://doi.org/10.1016/s0925-4773(97)00168-8
https://doi.org/10.1016/s0925-4773(97)00168-8
Autor:
Kathleen A. Mahon, Eric C. Swindell, Milan Jamrich, Travis J. Bailey, Felipe Amaya-Manzanares, Felix Loosli, Chaomei Liu, Joachim Wittbrodt
Publikováno v:
genesis. 44:361-363
Rx is a homeobox-containing gene that is critical for vertebrate eye development. Its expression domain delineates a field of cells from which the retina and the ventral hypothalamus develop. The 5' upstream regulatory sequences of the medaka fish Rx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8ff75a4740cc269b7a868e82ceb525
https://doi.org/10.1002/dvg.20225
https://doi.org/10.1002/dvg.20225
Publikováno v:
Nature. 387:603-607
Development of the vertebrate eye requires a series of steps including specification of the anterior neural plate, evagination of the optic vesicles from the ventral forebrain, and the cellular differentiation of the lens and retina. Homeobox-contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92425ba86b2a3a3f165f0d03a92613e
https://doi.org/10.1038/42475
https://doi.org/10.1038/42475
Autor:
Heiner Westphal, Ilan R. Kirsch, Albert F. Parlow, Kathleen A. Mahon, Forbes D. Porter, Deborah J. Good
Publikováno v:
Nature Genetics. 15:397-401
The family of basic helix-loop-helix (bHLH) genes comprises transcription factors involved in many aspects of growth and development. We have previously described two bHLH transcription factors, Nhlh1 and Nhlh2 (originally named NSCL1 and NSCL2). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a123ce6954fc3e61e77aa9db0bc121cc
https://doi.org/10.1038/ng0497-397
https://doi.org/10.1038/ng0497-397
Autor:
Heiner Westphal, Kathleen A. Mahon, Bedrich Mosinger, Stefano Bertuzzi, Alexander B. Zhadanov, Sing-Ping Huang, Hui Z. Sheng, Alexander Grinberg, Eric J. Lee, Tetsuya Fujii
Publikováno v:
Science. 272:1004-1007
During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Targeted gene disruption in mice showed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4cdbeee3383b6a77e7cf007c63cfaf
https://doi.org/10.1126/science.272.5264.1004
https://doi.org/10.1126/science.272.5264.1004
Autor:
Ronald A. DePinho, Sharon D. Morgenbesser, James W. Horner, Kathleen A. Mahon, Han Woong Lee, Kimi S. Hatton, Lynda Chin, Damin Peng, Fung Chow Chiu
Publikováno v:
Molecular and Cellular Biology. 16:1794-1804
To determine the role of L-Myc in normal mammalian development and its functional relationship to other members of the Myc family, we determined the normal patterns of L-myc gene expression in the developing mouse by RNA in situ hybridization and ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3554ef8c79bb4f12e01ab7396162015d
https://doi.org/10.1128/mcb.16.4.1794
https://doi.org/10.1128/mcb.16.4.1794