Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kathleen A, Elias"'
Autor:
Katjuša Brejc, Jeffrey T. Finer, Maria Pokrovskii, David R. Cox, Daniel W. Pierce, Marc Garard, Ramesh Baliga, Congrong Niu, Todd Tochimoto, Kathleen A. Elias, Guillermo Godinez, Stephen F. Vatner, You Tang Shen, Roman Sakowicz, Bradley P. Morgan, Sandra H. Sueoka, Pu Ping Lu, Fady I. Malik, Tatsuo Katori, Alexander Muci, David Lenzi, David J. Morgans, Corey Valdez, Sheila Sylvester, Kenneth Lee, Xiangping Qian, Ion Suehiro, Erica Kraynack, Raja Kawas, David A. Kass, James J. Hartman, Hector P. Rodriguez, Robert L. Anderson, Wenyue Wang
Publikováno v:
Science. 331:1439-1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b655534b7d4dbf40b4a85dea7dd873d
https://doi.org/10.1126/science.1200113
https://doi.org/10.1126/science.1200113
Autor:
Todd Tochimoto, Zhengping Wang, Erica Kraynack, Xiangping Qian, Sheila Sylvester, Ion Suehiro, Alexander Muci, Hong Jiang, S. Corey Valdez, Adam Lewis Tomasi, Smith Whitney W, Kenneth Lee, Robert F. Anderson, Marc Garard, James J. Hartman, Donghong Xu, Hector M. Rodriguez, Guillermo Godinez, Sandra H. Sueoka, Pu-Ping Lu, Scott Collibee, Fady I. Malik, Wenyue Wang, Raja Kawas, Bradley P. Morgan, Nebojsa Djordjevic, Kathleen A. Elias, David J. Morgans
Publikováno v:
ACS Medicinal Chemistry Letters. 1:472-477
We report the design, synthesis, and optimization of the first, selective activators of cardiac myosin. Starting with a poorly soluble, nitro-aromatic hit compound (1), potent, selective, and soluble myosin activators were designed culminating in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fa6e36712323135868eb9a2d577637
https://doi.org/10.1021/ml100138q
https://doi.org/10.1021/ml100138q
Autor:
Minh Nguyen, Shuichi Miyakawa, Gregory Landes, Mary Haak-Frendscho, Mark Armanini, Rinat Yerushalmi, Kathleen Ann Elias, Samuel Leung, Toshiyuki Mori, Toshimitsu Arai, Dongxia Gao, Junichi Kato, Karen A. Gelmon, Andrew D Simmons
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 21(24)
Purpose: The RET proto-oncogene has been implicated in breast cancer, and the studies herein describe the preclinical and safety assessment of an anti-RET antibody–drug conjugate (ADC) being developed for the treatment of breast cancer. Experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5fb9410fdbef321c9682da1203f950
https://pubmed.ncbi.nlm.nih.gov/26240273
https://pubmed.ncbi.nlm.nih.gov/26240273
Autor:
Natasha Shinsky, Lyn Powell-Braxton, Kathleen A. Elias, Wei-Qiang Gao, Gladys Ingle, Klaus D. Beck
Publikováno v:
Journal of Neurobiology. 39:142-152
Although insulin-like growth factor-I (IGF-I) can act as a neurotrophic factor for peripheral neurons in vitro and in vivo following injury, the role IGF-I plays during normal development and functioning of the peripheral nervous system is unclear. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::967f2221357c00358d7e5f027a740d6d
https://doi.org/10.1002/(sici)1097-4695(199904)39:1<142::aid-neu11>3.0.co
https://doi.org/10.1002/(sici)1097-4695(199904)39:1<142::aid-neu11>3.0.co
Publikováno v:
Pharmaceutical Research. 13:23-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331df5b125d9d4151129f32d150f76ad
https://doi.org/10.1023/a:1016060729594
https://doi.org/10.1023/a:1016060729594
Autor:
Robert S. McDowell, R G Hammonds, John Burnier, Michael J. Cronin, Gladys Ingle, Stanley Mark S, Thomas E. Rawson, Kathleen A. Elias, Todd C. Somers
Publikováno v:
Endocrinology. 136:5694-5699
Reexamination of the hexapeptide GH-releasing peptide (GHRP-6) structure/function has lead to the development of four novel classes of compound that stimulate GH release. Each class is represented as follows: a pentapeptide, G-7039; a tetrapeptide, G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba7c1474fcb9b56887810e9f5268a92
https://doi.org/10.1210/endo.136.12.7588325
https://doi.org/10.1210/endo.136.12.7588325
Autor:
Gregory Landes, Kathleen Ann Elias
Publikováno v:
Development of Antibody-Based Therapeutics ISBN: 9781441959539
In this chapter the preclinical considerations for antibody target discovery, validation, and in vitro and in vivo pharmacology will be discussed. A deep understanding of both the biology and the pathology of disease is essential for target identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f83ebafb2710f7cb8cb4b47d79976e30
https://doi.org/10.1007/978-1-4419-5955-3_8
https://doi.org/10.1007/978-1-4419-5955-3_8
Publikováno v:
DNA and Cell Biology. 9:369-375
The matrix upon which cells grow affects their morphology, growth rate, response to external stimuli, and protein synthesis. GH3 cells, a well-characterized rat pituitary tumor cell line, synthesize and secrete growth hormone and prolactin (Prl). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab1ffedd70efad7907dea2c974399ad
https://doi.org/10.1089/dna.1990.9.369
https://doi.org/10.1089/dna.1990.9.369
Autor:
Cynthia L, Adams, Vadim, Kutsyy, Daniel A, Coleman, Ge, Cong, Anne Moon, Crompton, Kathleen A, Elias, Donald R, Oestreicher, Jay K, Trautman, Eugeni, Vaisberg
Publikováno v:
Methods in enzymology. 414
Compounds with similar target specificities and modes of inhibition cause similar cellular phenotypes. Based on this observation, we hypothesized that we could quantitatively classify compounds with diverse mechanisms of action using cellular phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eabc13c78e8520fced990475ea434b48
https://pubmed.ncbi.nlm.nih.gov/17110206
https://pubmed.ncbi.nlm.nih.gov/17110206
Autor:
Daniel A. Coleman, Cynthia L. Adams, Vadim Kutsyy, Eugeni A. Vaisberg, Ge Cong, Kathleen A Elias, Anne M. Crompton, Donald R. Oestreicher, Jay Trautman
Compounds with similar target specificities and modes of inhibition cause similar cellular phenotypes. Based on this observation, we hypothesized that we could quantitatively classify compounds with diverse mechanisms of action using cellular phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ee9fc779838fac048e41eb3e61c949
https://doi.org/10.1016/s0076-6879(06)14024-0
https://doi.org/10.1016/s0076-6879(06)14024-0