Výsledky vyhledávání - "Kathleen, Thayne"

Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants

Autor: Daniel A. Ladin, Ahmed E. M. Elhassanny, Rukiyah Van Dross, Kathleen Thayne, Andrew J. Morris, Colin S. Burns, Robert A. Kobet, Allison S. Danell, Hussam Albassam, Eman Soliman

Publikováno v: Prostaglandins & Other Lipid Mediators. 142:9-23

The combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid, arachidonoyl-ethanolamide (AEA), was a potent inducer of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dac3afe3cda625c841a55fa334a01763
https://doi.org/10.1016/j.prostaglandins.2019.03.001

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Abstract B34: Defining an orthotopic, syngeneic metastatic melanoma model for characterizing the immunotherapeutic activity of the prostamide, 15dPMJ2

Autor: Rukiyah Van Dross, Kathleen Thayne, Ariel L. Myers

Publikováno v: Cancer Research. 80:B34-B34

Metastatic melanoma (MM) is the deadliest form of skin cancer in the United States, with one person dying from the disease every hour. Metastasis occurs when cells from the primary tumor enter the systemic circulation and grow at local and distant or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b98fdf939f5f66a0418812960c4f81dd
https://doi.org/10.1158/1538-7445.camodels2020-b34

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Prostaglandin D

Autor: Ahmed E M, Elhassanny, Daniel A, Ladin, Eman, Soliman, Hussam, Albassam, Andrew, Morris, Robert, Kobet, Kathleen, Thayne, Colin, Burns, Allison S, Danell, Rukiyah, Van Dross

Publikováno v: Prostaglandinsother lipid mediators. 142

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ad30adc0d71ef08bbdffdb080eafa71
https://pubmed.ncbi.nlm.nih.gov/30858059

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Do Fish Oil Omega-3 Fatty Acids Enhance Antioxidant Capacity and Mitochondrial Fatty Acid Oxidation in Human Atrial Myocardium via PPARγ Activation?

Autor: Alan P. Kypson, Daniel S. Lark, Timothy M. Darden, Kathleen Thayne, Evelio Rodriguez, John Mark Williams, Ethan J. Anderson, Mitchel Harris, W. Randolph Chitwood, Saame Raza Shaikh

Publikováno v: Antioxidants & Redox Signaling. 21:1156-1163

Studies in experimental models suggest that n-3 polyunsaturated fatty acids (PUFAs) improve metabolic and anti-inflammatory/antioxidant capacity of the heart, although the mechanisms are unclear and translational evidence is lacking. In this study, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5179e9558e983a6a0300652eb0a14dd
https://doi.org/10.1089/ars.2014.5888

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Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle

Autor: Lalage A. Katunga, Robert C. Hickner, Justin D. La Favor, Christopher J. Wingard, Ethan J. Anderson, Kelsey H. Fisher-Wellman, P. Darrell Neufer, Kathleen Thayne, Taylor A. Mattox

Publikováno v: The Journal of Physiology. 591:3471-3486

Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas HFHS diets are largely deleter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eaf4df04b65045f23d033cb856671de1
https://doi.org/10.1113/jphysiol.2013.254193

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Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n−3 polyunsaturated fatty acids

Autor: Kathleen Thayne, Mitchel Harris, Saame Raza Shaikh, Ethan J. Anderson, Kristen Carraway

Publikováno v: Biochemical Journal. 441:359-366

Diets replete with n−3 PUFAs (polyunsaturated fatty acids) are known to have therapeutic potential for the heart, although a specifically defined duration of the n−3 PUFA diet required to achieve these effects remains unknown, as does their mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8893af93ade367ba88aa6ed5e973a403
https://doi.org/10.1042/bj20110626

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Corrigendum to 'Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy' [Mol Metab 4 (6) (2015) 493–506]☆

Autor: Kathleen Thayne, Timothy M. Darden, Jimmy T. Efird, Jitka A. Virag, Ethan J. Anderson, Hazaim Alwair, Lalage A. Katunga, Cherese Beatty, Alan P. Kypson, Preeti Gudimella, Scott Abernathy, Taylor A. Mattox

Publikováno v: Molecular Metabolism, Vol 4, Iss 10, p 753 (2015)

Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa4ef6f463edf3fb074b9dcf0e76ffd
https://europepmc.org/articles/PMC4588427/

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Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation

Autor: Wesley T. O'Neal, W. Randolph Chitwood, Kathleen Thayne, Jimmy T. Efird, Ethan J. Anderson, Theodore C. Koutlas, Stephen W. Davies, Alan P. Kypson, Curtis A. Anderson, Lalage A. Katunga, Evelio Rodriguez, T. Bruce Ferguson, J.Mark Williams, Linda C. Kindell, Timothy M. Darden

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Onset of postoperative atrial fibrillation ( POAF ) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF , and the ability of clinicians to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eecd029e107c676184cf27fccb3d32
http://europepmc.org/articles/PMC3959694

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Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium

Autor: Robert M. Lust, Kathleen Thayne, Susan D. Kent, Tracy L. Johnson, Ethan J. Anderson, Harrison D. Blanton, Jonathan DeAntonio, Jitka A. I. Virag, Fatiha Moukdar, Jian Ding

We have previously shown that myocardial infarct size in nonreperfused hearts of mice with a functional deletion of the circadian rhythm gene mPer2 (mPer2-M) was reduced by 43%. We hypothesized that acute ischemia-reperfusion injury (I/R = 30 min I/2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72cb919f3bfc329c2887bd213ec3dba7
https://europepmc.org/articles/PMC3891252/

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