Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathleen, Schuck"'
Autor:
Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy O’Connor, Quentin Müller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf Groß, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert Hüser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Polarisation of metastasising cancer cells in circulation has not been investigated before. Here the authors identify single cell polarity as a distinct polarisation state of single cells in liquid phase, and show that perturbing single cell polarity
Externí odkaz:
https://doaj.org/article/e4d4ca03df544a909e2ed53aef5fd83a
Publikováno v:
Expert Opinion on Therapeutic Targets. 25:5-13
Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancer entities, which is characterized by abundant desmoplastic stroma. The stroma consists of extracellular matrix, infiltrating immune cells, cancer-associated fibroblasts (CAFs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76792fbcd4cd5861aed41a535140c948
https://doi.org/10.1080/14728222.2021.1857727
https://doi.org/10.1080/14728222.2021.1857727
Autor:
Susanne Raulefs, Zhiheng Zhang, Jörg Kleeff, Vanesa Fernández-Sáiz, Torsten Hechler, Guosheng Wang, Xiaoping Zou, Yuan Wan, Hongzhen Li, Helmut Friess, Hana Algül, Thomas Engleitner, Shanshan Shen, Christoph W. Michalski, Kalliope N. Diakopoulos, Yuanyuan Yu, Andre Mihaljevic, Yibin Deng, Roland Rad, Kathleen Schuck, Nadja Maeritz, Bo Kong, Maximilian Reichert, Verena Weber, Jingjing Li, Andreas Pahl, Rupert Öllinger
Publikováno v:
Gastroenterology. 161(5)
Background & Aims Promoted by pancreatitis, oncogenic KrasG12D triggers acinar cells' neoplastic transformation through acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia. Anterior gradient 2 (Agr2), a known inhibitor of p53,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48295f7e92200b3ed808a455d0c804a9
https://pubmed.ncbi.nlm.nih.gov/34303658
https://pubmed.ncbi.nlm.nih.gov/34303658
Autor:
Zhiheng Zhang, Jörg Kleeff, Nadja Maeritz, Susanne Raulefs, Xiaoping Zou, Helmut Friess, Christina Ludwig, Dianbo Yao, Kathleen Schuck, Metello Innocenti, Yamin Zhao, Shanshan Shen, Vivien Tissen, Achim Krüger, Christoph W. Michalski, Jan G. D’Haese, Rob A. van der Kammen, Carsten Jäger, Benjamin Schoeps, Anna Melissa Schlitter, Bo Kong
Background & Aims Oncogenic KrasG12D induces neoplastic transformation of pancreatic acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic process, and drives pancreatic ductal adenocarcinoma (PDAC). mTOR (mechanistic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34c09707c2496b2d8d168be927eda2
https://hdl.handle.net/10281/396252
https://hdl.handle.net/10281/396252
Autor:
Yamin, Zhao, Benjamin, Schoeps, Dianbo, Yao, Zhiheng, Zhang, Kathleen, Schuck, Vivien, Tissen, Carsten, Jäger, Anna Melissa, Schlitter, Rob, van der Kammen, Christina, Ludwig, Jan G, D'Haese, Susanne, Raulefs, Nadja, Maeritz, Shanshan, Shen, Xiaoping, Zou, Achim, Krüger, Jörg, Kleeff, Christoph W, Michalski, Helmut, Friess, Metello, Innocenti, Bo, Kong
Publikováno v:
Gastroenterology. 160(5)
Oncogenic KrasA mouse model of inflammation-accelerated KrasWe found that mTORC1 and mTORC2 are markedly activated in human and mouse ADM lesions, and cooperate to promote KrasHere, we show that mTORC1 and mTORC2 attain a dual, yet nonredundant regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4560c9a27e846ea57221b61a92f95f35
https://pubmed.ncbi.nlm.nih.gov/33388318
https://pubmed.ncbi.nlm.nih.gov/33388318
Autor:
Aristeidis Papargyriou, Rupert Öllinger, Steffen Teller, Katja Steiger, Maximilian Reichert, Karin Feldmann, Roland Rad, Katja Peschke, Wilko Weichert, Thomas Engleitner, Carlo Maurer, Dieter Saur, Rim Sabrina Jahan Sarker, Kathleen Schuck, Anil K. Rustgi, Günter Schneider, Roland M. Schmid
Publikováno v:
Cancer Research. 81:PR003-PR003
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibroblast-rich desmoplastic stroma which plays a critical role in the progression and therapeutic resistance of PDAC. The stroma is composed of extracellular matrix proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f027a9cd94bd7aa79d18881eb364ad1
https://doi.org/10.1158/1538-7445.tme21-pr003
https://doi.org/10.1158/1538-7445.tme21-pr003
Autor:
Helmut Friess, Y. Yu, Kathleen Schuck, Nadja Maeritz, J. Cao, Y. Zhao, Bo Kong, Zhiheng Zhang
Publikováno v:
Pancreatology. 20:S127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b2496236f7ffe8ceb8c0a0d1067b9d
https://doi.org/10.1016/j.pan.2020.07.232
https://doi.org/10.1016/j.pan.2020.07.232
Autor:
Beiyuan Fu, Dieter Saur, Christian Veltkamp, Thomas Engleitner, Alex Strong, Wolfgang Enard, Sebastian Mueller, Sebastian Lange, Magdalena Zukowska, Nina Schönhuber, Thorsten Kaltenbacher, Mathias J Friedrich, Ruby Banerjee, Maxim Barenboim, Hsi-Yu Yen, Julia Hess, Pentao Liu, Barbara Seidler, Swati Parekh, Björn Konukiewitz, Sabine Klein, Maximilian Zwiebel, Jorge de la Rosa, Lena Rad, Roman Maresch, Stefan Eser, Allan Bradley, Kathleen Schuck, Fernando Constantino-Casas, Roland Rad, Juliana Götzfried, Sandra Louzada, Fengtang Yang, Günter Klöppel, Christoph Ziegenhain, Mario F. Fraga, Marta I. Sierra, Ignacio Varela, Juan Cadiñanos, Rupert Öllinger, Wilko Weichert, Zonera Hassan, Katja Steiger, Günter Schneider, Oliver M. Dovey, Julia Mayerle, Kristian Unger, George S. Vassiliou, Andreas Arbeiter, Roland M. Schmid
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature 554, 62-68 (2018)
Nature
instname
Nature 554, 62-68 (2018)
Nature
The poor correlation of mutational landscapes with phenotypes limits our understanding of the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we show that oncogenic dosage-variation has a critical role in PDAC biology and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e231b6da1f1430a840ea2a8fe3e3f859
http://hdl.handle.net/10261/173621
http://hdl.handle.net/10261/173621
Autor:
Kathleen Schuck, N. Volkan Adsay, Anil K. Rustgi, Albert B. Reynolds, Lauren Simon, Karin Feldmann, Dieter Saur, Wilko Weichert, Matthias Wirth, Anna Melissa Schlitter, Basil Bakir, Burcin Pehlivanoglu, Andres J. Klein-Szanto, Andrew D. Rhim, Leticia Moreira, Günter Schneider, Bahar Memis, Maximilian Reichert, Kensuke Suzuki, Ravikanth Maddipati, Jason R. Pitarresi, Mark Kriegsmann
Publikováno v:
Developmental Cell
Summary The regulation of metastatic organotropism in pancreatic ductal a denocarcinoma (PDAC) remains poorly understood. We demonstrate, using multiple mouse models, that liver and lung metastatic organotropism is dependent upon p120catenin ( p120ct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56436d38abe66b781ad7f4bd4e649d65
https://pubmed.ncbi.nlm.nih.gov/30613628
https://pubmed.ncbi.nlm.nih.gov/30613628
Publikováno v:
ESMO Open. 3:A99-A100
Introduction The role of epithelial to mesenchymal transition in metastatic processes remains a controversial field. While EMT is easily accessible in vitro , tracking EMT cells in vivo has been difficult for a long time. Therefore we created a dual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6a9d7bbc59141ef2e64b2bf7d4f850
https://doi.org/10.1136/esmoopen-2018-eacr25.239
https://doi.org/10.1136/esmoopen-2018-eacr25.239