Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kathleen, Klotz"'
Autor:
Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-17 (2021)
Abstract In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to define transcriptional states of colorectal cancer cells and sig
Externí odkaz:
https://doaj.org/article/cc6f299b784d44ffb0f05c6f27ba79b1
Autor:
Kathleen Klotz-Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Pamela Riemer, Mareen Lüthen, Thomas Sell, Katharina Kasack, Bastian Gastl, Sylvia S.S. Ispasanie, Tincy Simon, Nicole Janssen, Matthias Schwab, Johannes Zuber, David Horst, Nils Blüthgen, Reinhold Schäfer, Markus Morkel, Christine Sers
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108184- (2020)
Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly r
Externí odkaz:
https://doaj.org/article/2950671e43df461fba99d304a2fcf743
Autor:
Irem Ozkan-Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S.K. Gilbert, Kevin H. Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F. Petricoin, III, Nhan L. Tran, Shripad V. Bhagwat, Ramon V. Tiu, Sheng-Bin Peng, Laura E. Herring, Lee M. Graves, Christine Sers, Kris C. Wood, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107764- (2020)
Summary: We address whether combinations with a pan-RAF inhibitor (RAFi) would be effective in KRAS mutant pancreatic ductal adenocarcinoma (PDAC). Chemical library and CRISPR genetic screens identify combinations causing apoptotic anti-tumor activit
Externí odkaz:
https://doaj.org/article/5756388e183142489ccb4823f8985e8f
Autor:
Charles Spruck, Olle Sangfelt, Martin Widschwendter, Steven I. Reed, Dan Grander, Hans Nordgren, Per Sangfelt, Fredrik Petersson, Susanne Egyhazi, Johan Hansson, Mohammad Reza Zali, Babak Noori Nayer, Sepideh Zabihi Nejad, Markus Dagnell, Martin Corcoran, Elisabeth Mueller-Holzner, Christian Marth, Dimitra Dofou, Heidi Fiegl, Diana Cepeda, Alena Maljukova, Kathleen Klotz, Sophia Apostolidou, Natalie von der Lehr, Dahui Sun, Shahab Akhoondi
Supplementary Table 1 from FBXW7/hCDC4 Is a General Tumor Suppressor in Human Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ecf68db5a7048c1c006ed29fe6c1b
https://doi.org/10.1158/0008-5472.22371378.v1
https://doi.org/10.1158/0008-5472.22371378.v1
Autor:
Charles Spruck, Martin Widschwendter, James Wohlschlegel, Ajay A. Vashisht, Kathleen Klotz-Noack, Weijian Jiang, Dahui Sun, YingMeei Tan
PDF file - 212KB, Representative gene expression studies demonstrating overexpression of PPP2R2B in human cancers. Data obtained from the ONCOMINE database (2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f69061441ea41614a9ae7557ed42f32
https://doi.org/10.1158/0008-5472.22400964.v1
https://doi.org/10.1158/0008-5472.22400964.v1
Autor:
Charles Spruck, Martin Widschwendter, James Wohlschlegel, Ajay A. Vashisht, Kathleen Klotz-Noack, Weijian Jiang, Dahui Sun, YingMeei Tan
PDF file - 84KB, Cyclin E1 protein levels do not correlate with B56beta (A), B56delta (B), or Fbxw7alpha (C) expression in breast cancers. Fresh-frozen breast cancer specimens were analyzed for cyclin E1 protein by Western blotting and B56beta, B56de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca8eb8787894d6d7f7385afcb1ae1ad
https://doi.org/10.1158/0008-5472.22400967
https://doi.org/10.1158/0008-5472.22400967
Autor:
Charles Spruck, Martin Widschwendter, James Wohlschlegel, Ajay A. Vashisht, Kathleen Klotz-Noack, Weijian Jiang, Dahui Sun, YingMeei Tan
Cyclin E1 regulates the initiation of S-phase in cellular division. However, in many cancers, cyclin E1 is aberrantly overexpressed and this molecular phenotype correlates with increased tumor aggressiveness and poor patient survival. The molecular c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b0e96ab6d0c04bca265985802dd2c26
https://doi.org/10.1158/0008-5472.c.6505728
https://doi.org/10.1158/0008-5472.c.6505728
Autor:
Charles Spruck, Martin Widschwendter, James Wohlschlegel, Ajay A. Vashisht, Kathleen Klotz-Noack, Weijian Jiang, Dahui Sun, YingMeei Tan
PDF file - 167KB, Transfection of MDA-MB-231 cells with three different B55beta siRNAs decreases cyclin E1 protein level. Cells were harvested 48 hrs post-transfection. All subsequent experiments were performed using B55beta-siRNA-2. qPCR data showin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204a2c0d6b9cb0183a5c9eda8d7d6edd
https://doi.org/10.1158/0008-5472.22400973
https://doi.org/10.1158/0008-5472.22400973
Autor:
Charles Spruck, Olle Sangfelt, Martin Widschwendter, Steven I. Reed, Dan Grander, Hans Nordgren, Per Sangfelt, Fredrik Petersson, Susanne Egyhazi, Johan Hansson, Mohammad Reza Zali, Babak Noori Nayer, Sepideh Zabihi Nejad, Markus Dagnell, Martin Corcoran, Elisabeth Mueller-Holzner, Christian Marth, Dimitra Dofou, Heidi Fiegl, Diana Cepeda, Alena Maljukova, Kathleen Klotz, Sophia Apostolidou, Natalie von der Lehr, Dahui Sun, Shahab Akhoondi
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition components of the multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23907af830a4be9a61f44daaab6df85
https://doi.org/10.1158/0008-5472.c.6496770
https://doi.org/10.1158/0008-5472.c.6496770
Autor:
Charles Spruck, Martin Widschwendter, James Wohlschlegel, Ajay A. Vashisht, Kathleen Klotz-Noack, Weijian Jiang, Dahui Sun, YingMeei Tan
PDF file - 73KB, B55beta expression knockdown inhibits the growth and decreases cyclin E1 protein levels in colorectal cancer cell lines containing hypermethylated PP2R2B alleles (3). A, Growth of HT29 and HCT116 colorectal carcinoma cells transfecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f50e1dbfd174b7d59e69faeb63d19a1
https://doi.org/10.1158/0008-5472.22400961
https://doi.org/10.1158/0008-5472.22400961