Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Kathleen, H Burns"'
Autor:
Irina R. Arkhipova, Kathleen H. Burns, Katherine B. Chiappinelli, Edward B. Chuong, Clement Goubert, Alba Guarné, Amanda M. Larracuente, E. Alice Lee, Henry L. Levin
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The conference “Transposable Elements at the Crossroads of Evolution, Health and Disease” was hosted by Keystone Symposia in Whistler, British Columbia, Canada, on September 3–6, 2023, and was organized by Kathleen Burns, Harmit Malik
Externí odkaz:
https://doaj.org/article/ea3d4033cdaa4121823068b3340dce6f
Autor:
Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon, John M. Coffin, Daniel D. DeCarvalho, Joseph D. Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K. Knutson, Arnold J. Levine, Avindra Nath, Sophie Papa, Daniel Rios, John Sedivy, David T. Ting
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape
Externí odkaz:
https://doaj.org/article/afb42101dc1c4afbabb0c6b4ea01ef97
Autor:
Kevin C. L. Cheng, Jennifer M. Frost, Francisco J. Sánchez-Luque, Marta García-Canãdas, Darren Taylor, Wan R. Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam Ewing, José L. García-Pérez, Miguel R. Branco
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation, and Jumonji-domain histone demethylases. The epigenetic remodelling promoted by vitC improve
Externí odkaz:
https://doaj.org/article/f795feb9ee214159af694527040dae95
Autor:
Sho Sato, Michael Gillette, Pamela R. de Santiago, Eric Kuhn, Michael Burgess, Kristen Doucette, Yi Feng, Carlos Mendez-Dorantes, Paul J. Ippoliti, Sara Hobday, Marilyn A. Mitchell, Kai Doberstein, Stefan M. Gysler, Michelle S. Hirsch, Lauren Schwartz, Michael J. Birrer, Steven J. Skates, Kathleen H. Burns, Steven A. Carr, Ronny Drapkin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p is not only expressed but also r
Externí odkaz:
https://doaj.org/article/4b43d6de805a4bc5b6fd254961a19c5f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The identification of events occurring at target sites is critical to determine the safety of CRISPRbased DNA editing tools. Here, the authors show that LINE-1 retrotranspositions can occur frequently at canonical CRISPR/Cas9 editing sites, but are r
Externí odkaz:
https://doaj.org/article/475fb6a4bb494f549c6452ac89c19a9d
Autor:
Hale Tunbak, Rocio Enriquez-Gasca, Christopher H. C. Tie, Poppy A. Gould, Petra Mlcochova, Ravindra K. Gupta, Liane Fernandes, James Holt, Annemarthe G. van der Veen, Evangelos Giampazolias, Kathleen H. Burns, Pierre V. Maillard, Helen M. Rowe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The HUSH complex has been implicated in repressing LINE-1 elements. Here the authors reveal that the complex negatively regulates the type I IFN response in human cells through epigenetic regulation of LINE-1 elements
Externí odkaz:
https://doaj.org/article/ee339e70658d4865897566aa7c7f8a90
Autor:
Xiaolong Cao, Yeting Zhang, Lindsay M. Payer, Hannah Lords, Jared P. Steranka, Kathleen H. Burns, Jinchuan Xing
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Mobile elements are a major source of structural variants in the human genome, and some mobile elements can regulate gene expression and transcript splicing. However, the impact of polymorphic mobile element insertions (pMEIs) on
Externí odkaz:
https://doaj.org/article/310f26900f1a4e72992e3750ee034dd7
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Background Mobile elements are ubiquitous components of mammalian genomes and constitute more than half of the human genome. Polymorphic mobile element insertions (pMEIs) are a major source of human genomic variation and are gaining research
Externí odkaz:
https://doaj.org/article/d4e7a944c55b41388a9c6fc00748babf
Autor:
Daniel Ardeljan, Xuya Wang, Mehrnoosh Oghbaie, Martin S. Taylor, David Husband, Vikram Deshpande, Jared P. Steranka, Mikhail Gorbounov, Wan Rou Yang, Brandon Sie, H. Benjamin Larman, Hua Jiang, Kelly R. Molloy, Ilya Altukhov, Zhi Li, Wilson McKerrow, David Fenyö, Kathleen H. Burns, John LaCava
Publikováno v:
Mobile DNA, Vol 11, Iss 1, Pp 1-19 (2019)
Abstract Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and OR
Externí odkaz:
https://doaj.org/article/20049d0c7d7043acb41589f76709b424
Autor:
Laura M. Wake MD, Derek B. Allison MD, Alisha D. Ware MD, Jody E. Hooper MD, Alex S. Baras MD, PhD, Evan M. Bloch MBChB, MS, William Clarke PhD, Kathleen H. Burns MD, PhD, Karen S. Sfanos MS, PhD, Michael J. Borowitz MD, PhD, Charles Steenbergen MD, PhD, Ralph H. Hruban MD, Marissa J. White MD
Publikováno v:
Academic Pathology, Vol 8 (2021)
Pathologists who enter the workforce must have a diverse skill set beyond that of clinical diagnostics alone. Anticipating this need, the Johns Hopkins Pathology Residency Program developed Special Expertise Tracks to enhance training in relevant sub
Externí odkaz:
https://doaj.org/article/a86339f24c504feabc4054c257fe2eee