Výsledky vyhledávání - "Kathleen, Burks"

High-dose topotecan with granulocyte-colony stimulating factor in fluoropyrimidine-refractory colorectal cancer: A phase II and pharmacodynamic study

Autor: Seamus O'Reilly, Sharyn D. Baker, Ross C. Donehower, Louise B. Grochow, Eric K. Rowinsky, Kathleen Burks

Publikováno v: Annals of Oncology. 9:173-180

PURPOSE The premise for this study was that topotecan (TPT) resistance in preclinical studies is associated with low level expression of the p-glycoprotein (Pgp) multi-drug transporter conferred by the multi-drug resistant (MDR) phenotype, which migh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b8e32db7e8d4592e66f8fb603831ca
https://doi.org/10.1023/a:1008266630701

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Absence of a Primary Role for SCN10A Mutations in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Autor: Brittney Murray, Crystal Tichnell, Anneline S.J.M. te Riele, Cynthia A. James, Hugh Calkins, Daniel P. Judge, Michael Polydefkis, Nuria Amat-Alarcon, Kathleen Burks, Harikrishna Tandri

Publikováno v: Journal of Cardiovascular Translational Research, 9(1), 87. Springer New York
J Cardiovasc Transl Res

Prior reports have identified associations between SCN10A and cardiac disorders, such as atrial fibrillation and Brugada syndrome. We evaluated SCN10A in 151 probands with ARVD/C. In this cohort, 10 putatively pathogenic SCN10A variants were identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebfdb0fb9aeb0eceb135777c5ef600b
https://hdl.handle.net/1874/343555

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Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia

Autor: Steven D, Gore, Li-Jun, Weng, William D, Figg, Suoping, Zhai, Ross C, Donehower, George, Dover, Michael R, Grever, Constance, Griffin, Louise B, Grochow, Anita, Hawkins, Kathleen, Burks, Yelena, Zabelena, Carole B, Miller

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 8(4)

The aromatic fatty acid sodium phenylbutyrate (PB) promotes cytostasis and differentiation in a wide variety of tumor types; among several molecular activities, inhibition of histone deacetylase (HDAC) may account for many of its pharmacodynamic effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::727148432aa88e9b182b8eca01f299a4
https://pubmed.ncbi.nlm.nih.gov/11948101

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