Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kathiresan Selvam"'
Autor:
Kathiresan Selvam, Jun Xu, Hannah E. Wilson, Juntaek Oh, Qingrong Li, Dong Wang, John J. Wyrick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Transcription coupled-nucleotide excision repair (TC-NER) removes DNA lesions that block RNA polymerase II (Pol II) transcription. A key step in TC-NER is the recruitment of the TFIIH complex, which initiates DNA unwinding and damage verific
Externí odkaz:
https://doaj.org/article/ad0f7127914e449194ad0e44a7411397
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Sequencing of melanomas has identified hundreds of recurrent mutations in both coding and non-coding DNA. These include a number of well-characterized oncogenic driver mutations, such as coding mutations in the BRAF and NRAS oncogenes, and n
Externí odkaz:
https://doaj.org/article/a0d331b434214dffa3c79b8525560539
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010085 (2022)
Helix-distorting DNA lesions, including ultraviolet (UV) light-induced damage, are repaired by the global genomic-nucleotide excision repair (GG-NER) and transcription coupled-nucleotide excision repair (TC-NER) pathways. Previous studies have shown
Externí odkaz:
https://doaj.org/article/2815aac52fe04881b821cb0312c42571
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69007 (2013)
Mutants created by deleting the ddrA, ddrB, ddrC, ddrD, and pprA loci of Deinococcus radiodurans R1alone and in all possible combinations of pairs revealed that the encoded gene products contribute to this species' resistance to UV light and/or mitom
Externí odkaz:
https://doaj.org/article/19c7ed72f22e4e9abb33104955cb6455
Autor:
Wenzhi Gong, Richard Mitter, Wim Vermeulen, Dalton A Plummer, Chirantani Mukherjee, Marvin van Toorn, Karel Bezstarosti, Jesper Q. Svejstrup, Arjan F. Theil, Arnab Ray Chaudhuri, Anja Raams, Melanie van der Woude, John J. Wyrick, René Bernards, Yannick P Kok, Marcel A. T. M. van Vugt, Jurgen A. Marteijn, Barbara Steurer, Simona Cugusi, Adriaan B Houtsmuller, Jeroen Demmers, Shisheng Li, Joyce H.G. Lebbink, Kathiresan Selvam, Bart Geverts, Hannes Lans, Roel C. Janssens, Marit E. Geijer, Di Zhou, Bastiaan Evers, Calvin Shun Yu Lo
Publikováno v:
Nature Cell Biology, 23(6), 608-619. Nature Publishing Group
Nature cell biology
Nat Cell Biol
Nature cell biology
Nat Cell Biol
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8be2132ea5385e582a7d0be3b3d819
https://doi.org/10.1038/s41556-021-00692-z
https://doi.org/10.1038/s41556-021-00692-z
Publikováno v:
Proc Natl Acad Sci U S A
Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mechanism that removes RNA polymerase (RNAP)-stalling DNA damage from the transcribed strand (TS) of active genes. TC-NER deficiency in humans is associated with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4d78ef85fbef0c01f9cbe21bfdea33
https://doi.org/10.1073/pnas.2003868117
https://doi.org/10.1073/pnas.2003868117
Publikováno v:
Nucleic Acids Research
Nucleotide excision repair (NER) consists of global genomic NER (GG-NER) and transcription coupled NER (TC-NER) subpathways. In eukaryotic cells, genomic DNA is wrapped around histone octamers (an H3–H4 tetramer and two H2A–H2B dimers) to form nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81df4705cebf4bbf95067d56462845d
https://doi.org/10.1093/nar/gkz453
https://doi.org/10.1093/nar/gkz453
Publikováno v:
Journal of Molecular Biology. 431:1322-1338
Transcription coupled repair (TC-NER) is a subpathway of nucleotide excision repair triggered by stalling of RNA polymerase at DNA lesions. It has been suspected that transcriptional misincorporations of certain nucleotides opposite lesions that resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eeaebc9cf3e34499da8f3a8d60d9e6c
https://doi.org/10.1016/j.jmb.2019.02.010
https://doi.org/10.1016/j.jmb.2019.02.010
Autor:
René Bernards, Anja Raams, Jurgen A. Marteijn, Jesper Q. Svejstrup, Di Zhou, Arnab Ray Chaudhuri, Chirantani Mukherjee, Marvin van Toorn, Melanie van der Woude, Barbara Steurer, Arjan F. Theil, Wim Vermeulen, Joyce H.G. Lebbink, Kathiresan Selvam, Simona Cugusi, Adriaan B. Houtsmuller, Bart Geverts, Shisheng Li, Marit E. Geijer, Karel Bezstarosti, Bastiaan Evers, Hannes Lans, Jeroen Demmers, Roel C. Janssens, John J. Wyrick, Wenzhi Gong, Richard Mitter, Dalton A Plummer
Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA Polymerase II (Pol II), causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counterac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cae2bdda9091fcb8bbddab66b9eb692
https://doi.org/10.1101/2021.05.11.443558
https://doi.org/10.1101/2021.05.11.443558
