Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Kathiresan, Krishnan"'
Autor:
Alice Dupont Juhl, Christian W. Heegaard, Stephan Werner, Gerd Schneider, Kathiresan Krishnan, Douglas F. Covey, Daniel Wüstner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract Mitochondria receive cholesterol from late endosomes and lysosomes (LE/LYSs) or from the plasma membrane for production of oxysterols and steroid hormones. This process depends on the endo-lysosomal sterol transfer protein Niemann Pick C2 (N
Externí odkaz:
https://doaj.org/article/9c8c613b5a6d43229d449d238c083ed0
Autor:
Tamara Timic Stamenic, Francesca M. Manzella, Stefan Maksimovic, Kathiresan Krishnan, Douglas F. Covey, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
We recently reported that a neurosteroid analogue with T-channel-blocking properties (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH), induced hypnosis in rat pups without triggering neuronal apoptosis. Furthermore, we found that the inhib
Externí odkaz:
https://doaj.org/article/81ceb9b8553949458fa215c3060c28cb
Autor:
Makoto Ishikawa, Toru Nakazawa, Hiroshi Kunikata, Kota Sato, Takeshi Yoshitomi, Kathiresan Krishnan, Douglas F. Covey, Charles F. Zorumski, Yukitoshi Izumi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABAA receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely ina
Externí odkaz:
https://doaj.org/article/8debbb05cfa341cf9e039f7b3d81b327
Autor:
Noah M Dietzen, Mark J Arcario, Lawrence J Chen, John T Petroff II, K Trent Moreland, Kathiresan Krishnan, Grace Brannigan, Douglas F Covey, Wayland WL Cheng
Publikováno v:
eLife, Vol 11 (2022)
Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively th
Externí odkaz:
https://doaj.org/article/28bf0dd55ae64ba8b05cd03aeee35398
Autor:
McKenna Feltes, Samantha Moores, Sarah E. Gale, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F. Covey, Daniel S. Ory, Jean E. Schaffer
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 707-716 (2019)
Cholesterol is an essential structural component of cellular membranes and precursor molecule for oxysterol, bile acid, and hormone synthesis. The study of intracellular cholesterol trafficking pathways has been limited in part due to a lack of suita
Externí odkaz:
https://doaj.org/article/c2707b2c456643b7949e0c4f05ab5a12
Autor:
Yusuke Sugasawa, Wayland WL Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert, Douglas F Covey, Gustav Akk, Alex S Evers
Publikováno v:
eLife, Vol 9 (2020)
This study examines how site-specific binding to three identified neurosteroid-binding sites in the α1β3 GABAA receptor (GABAAR) contributes to neurosteroid allosteric modulation. We found that the potentiating neurosteroid, allopregnanolone, but n
Externí odkaz:
https://doaj.org/article/28aa0ecba7e8446f9f22fbe67ffe09fd
Autor:
Quy L. Tat, Srdjan M. Joksimovic, Kathiresan Krishnan, Douglas F. Covey, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Publikováno v:
Cells, Vol 9, Iss 12, p 2674 (2020)
Preemptive management of post-incisional pain remains challenging. Here, we examined the role of preemptive use of neuroactive steroids with activity on low-voltage activated T-type Ca2+ channels (T-channels) and γ-aminobutyric acid A (GABAA) recept
Externí odkaz:
https://doaj.org/article/9ca0b9f4a4cc426288ddcb11aff33e74
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Autor:
David B. Iaea, Sarah E. Gale, Agata A. Bielska, Kathiresan Krishnan, Hideji Fujiwara, Hui Jiang, Frederick R. Maxfield, Paul H. Schlesinger, Douglas F. Covey, Jean E. Schaffer, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2408-2419 (2015)
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhib
Externí odkaz:
https://doaj.org/article/b39cd01c69ac4c3ba074d9078dceaab5
Autor:
Kathiresan Krishnan, Zi-Wei Chen, Lei Wang, David E. Reichert, Daniel S. Ory, McKenna Feltes, Alex S. Evers, Jean E. Schaffer, Yusuke Sugasawa, Douglas F. Covey, Mingxing Qian, Sarah E. Gale
Publikováno v:
ACS Chem Biol
Aliphatic diazirine analogues of cholesterol have been used previously to elaborate the cholesterol proteome and identify cholesterol binding sites on proteins. Cholesterol analogues containing the trifluoromethylphenyl diazirine (TPD) group have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a69d3b7995c8bcb0e4f0032df5bd6c
https://doi.org/10.1021/acschembio.1c00364
https://doi.org/10.1021/acschembio.1c00364
Autor:
Maia Kinnebrew, Rachel E. Woolley, T. Bertie Ansell, Eamon F. X. Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S. P. Sansom, Douglas F. Covey, Christian Siebold, Rajat Rohatgi
Publikováno v:
Science Advances. 8
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and a second in the transmembrane domain (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecbac756ffd5793e4e4f0b3695b007b
https://doi.org/10.1126/sciadv.abm5563
https://doi.org/10.1126/sciadv.abm5563