Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kathi, Zarnack"'
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 901-916 (2024)
CircRNAs are an important class of RNAs with diverse cellular functions in human physiology and disease. A thorough knowledge of circRNAs including their biogenesis and subcellular distribution is important to understand their roles in a wide variety
Externí odkaz:
https://doaj.org/article/9998bf91e67f4d61935476da96e7a7e2
Autor:
Simone Franziska Glaser, Andre Brezski, Nina Baumgarten, Marius Klangwart, Andreas W. Heumüller, Ranjan Kumar Maji, Matthias S. Leisegang, Stefan Guenther, Christoph M. Zehendner, David John, Marcel H. Schulz, Kathi Zarnack, Stefanie Dimmeler
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112824- (2023)
Summary: Circular RNAs are generated by backsplicing and control cellular signaling and phenotypes. Pericytes stabilize capillary structures and play important roles in the formation and maintenance of blood vessels. Here, we characterize hypoxia-reg
Externí odkaz:
https://doaj.org/article/842d9acd005e4875bfd4b93449b53350
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Megan A. Palmer, Vanesa Maria Guerrero Ruiz, Giulia Cardamone, Silvia Rösser, Milou Heffels, Fabian Roesmann, Alexander Wilhelm, Dieter Lütjohann, Kathi Zarnack, Dominik Christian Fuhrmann, Marek Widera, Tobias Schmid, Bernhard Brüne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases. We characterized the impact of hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses. Specifically, hypox
Externí odkaz:
https://doaj.org/article/0529142dc6c74d528346fa922d05bbcf
Autor:
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz:
https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3
Autor:
Oliver Daniel Schwich, Nicole Blümel, Mario Keller, Marius Wegener, Samarth Thonta Setty, Melinda Elaine Brunstein, Ina Poser, Igor Ruiz De Los Mozos, Beatrix Suess, Christian Münch, François McNicoll, Kathi Zarnack, Michaela Müller-McNicoll
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-34 (2021)
Abstract Background Alternative polyadenylation (APA) refers to the regulated selection of polyadenylation sites (PASs) in transcripts, which determines the length of their 3′ untranslated regions (3′UTRs). We have recently shown that SRSF3 and S
Externí odkaz:
https://doaj.org/article/636b189fddc14c0eaedf12314fffd4e1
Autor:
Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Susan Boerner, Jan B. Heidelberger, Anke Busch, Heike Hänel, Andrea Voigt, Martin M. Möckel, Stefanie Ebersberger, Anica Scholz, Annabelle Dold, Tobias Schmid, Ingo Ebersberger, Jean-Yves Roignant, Kathi Zarnack, Julian König, Petra Beli
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-20 (2019)
Abstract Background Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional
Externí odkaz:
https://doaj.org/article/184af80dfd314f3694eb2622520459ab
Autor:
Camila de Oliveira Freitas Machado, Michal Schafranek, Mirko Brüggemann, María Clara Hernández Cañás, Mario Keller, Antonella Di Liddo, Andre Brezski, Nicole Blümel, Benjamin Arnold, Anja Bremm, Ilka Wittig, Nicolas Jaé, François McNicoll, Stefanie Dimmeler, Kathi Zarnack, Michaela Müller-McNicoll
Publikováno v:
Nucleic Acids Research. 51:870-890
Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to hypoxia. The SRSF6 level is strongly reduced in acute hypoxia, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0312fcd3683a8dd4ea5d79362d612aa
https://doi.org/10.1093/nar/gkac1225
https://doi.org/10.1093/nar/gkac1225
Autor:
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner
Publikováno v:
eLife, Vol 9 (2020)
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensat
Externí odkaz:
https://doaj.org/article/b68b2bc2ff684844afe3e2ee6dd99ca4
Autor:
Annabelle Dold, Hong Han, Niankun Liu, Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Heike Hänel, Anke Busch, Petra Beli, Kathi Zarnack, Julian König, Jean-Yves Roignant, Paul Lasko
Publikováno v:
PLoS Genetics, Vol 16, Iss 1, p e1008581 (2020)
Makorins are evolutionary conserved proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been linked to embryonic patterning but the mechanism remained unsolved. Here,
Externí odkaz:
https://doaj.org/article/f269777d24fd405bb6f2a90e862f6c95