Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kathi, Williams"'
Autor:
Jeff Lutman, Saloumeh K Fischer, Sid Sukumaran, Catherine Huang, Tracy Bentley, Keyang Xu, Gizette Sperinde, Luna Liu, Martha Hokom, Kathi Williams
Publikováno v:
Bioanalysis. 14(1)
Aim: Development of recombinant fusion proteins as drugs poses unique challenges for bioanalysis. This paper describes a case study of a glycosylated fusion protein, where variable glycosylation, matrix interference and high sensitivity needs posed u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b80114b17e3f8b33baa45adade66d4a
https://pubmed.ncbi.nlm.nih.gov/34789009
https://pubmed.ncbi.nlm.nih.gov/34789009
Publikováno v:
Bioanalysis. 11:1777-1785
Aim: Bedside or point-of-care testing (POCT) provides immediate results, allowing for rapid clinical decision making and management of critically ill patients. IL-6 is a central mediator in cytokine release syndrome and sepsis, two potentially life-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4191a0e60dda1376eaeb220ea973853c
https://doi.org/10.4155/bio-2019-0192
https://doi.org/10.4155/bio-2019-0192
Autor:
Juan Jenny Li, Yuwen Linda Lin, Saileta Prabhu, Kevin Lin, Suzie J. Scales, Gizette Sperinde, Shan Chung, Kathi Williams, Saloumeh K Fischer, James A. Ernst, Kai Zheng, An Song, Siddharth Sukumaran, Julien Lafrance-Vanasse, Van Nguyen, Devin Tesar, Rong Deng, Greg A. Lazar
Publikováno v:
mAbs. 11:942-955
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd5cc1f2d9b349c5ce6517191eeda48
https://doi.org/10.1080/19420862.2019.1605270
https://doi.org/10.1080/19420862.2019.1605270
Publikováno v:
Bioanalysis. 13(9)
Background: Low volume sampling technologies have come a long way; however, their uptake has been slow due to logistical and perceived implementation challenges. Additional studies are needed to overcome these barriers. Materials & methods/results: H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9024fa0899ffc366f9e2a2b13172030f
https://pubmed.ncbi.nlm.nih.gov/33900106
https://pubmed.ncbi.nlm.nih.gov/33900106
Autor:
Ian Harmon, Emmanuel Capio, Mikhail Briman, Saloumeh K Fischer, Hua Xu, Bryan Bothwell, Kathi Williams
Publikováno v:
Bioanalysis. 12(20)
Aim: Current blood monitoring methods require sample collection and testing at a central lab, which can take days. Point of care (POC) devices with quick turnaround time can provide an alternative with faster results, allowing for real-time data lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775e54cb6dd7dd93957aead96c645e8d
https://pubmed.ncbi.nlm.nih.gov/32975432
https://pubmed.ncbi.nlm.nih.gov/32975432
Publikováno v:
Bioanalysis. 9:1207-1216
Aim: Etrolizumab, a humanized monoclonal antibody, has demonstrated clinical remission in a Phase II study of ulcerative colitis patients. In the Phase III program, a second indication, Crohn's disease was added. The pharmacokinetic ELISA used in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ae5e5a4e01c8b601d4154f4f6e56fa
https://doi.org/10.4155/bio-2017-0102
https://doi.org/10.4155/bio-2017-0102
Autor:
Shan, Chung, Van, Nguyen, Yuwen Linda, Lin, Julien, Lafrance-Vanasse, Suzie J, Scales, Kevin, Lin, Rong, Deng, Kathi, Williams, Gizette, Sperinde, Juan Jenny, Li, Kai, Zheng, Siddharth, Sukumaran, Devin, Tesar, James A, Ernst, Saloumeh, Fischer, Greg A, Lazar, Saileta, Prabhu, An, Song
Publikováno v:
mAbs
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b24934924be00d9ba5b5fc66744542b7
https://pubmed.ncbi.nlm.nih.gov/30982394
https://pubmed.ncbi.nlm.nih.gov/30982394
Publikováno v:
Bioanalysis. 5:1649-1659
Background: In the bioanalytical laboratory, challenges associated with manual, repetitive, labor-intensive processes can be addressed by powerful automated liquid handlers; however, their implementation has been difficult due to lack of efficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193bb6f5d73b097e32140f6bdee8cc71
https://doi.org/10.4155/bio.13.123
https://doi.org/10.4155/bio.13.123
Publikováno v:
Analytical Biochemistry. 316:92-102
We have developed a LabChip-based plasmid assay that runs on the Agilent 2100 Bioanalyzer. The assay determines the sizes and relative concentrations of the multiple forms of plasmid samples. Twelve samples can be analyzed on each chip in an automate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b026abbd1f284bbc6dc47e621ca349c6
https://doi.org/10.1016/s0003-2697(03)00037-x
https://doi.org/10.1016/s0003-2697(03)00037-x
Autor:
Luc J. Bousse, Abdel Minalla, Robert S. Dubrow, Stephane Mouradian, Kathi Williams, Herman Yee
Publikováno v:
Analytical Chemistry. 73:1207-1212
We have developed a microfabricated analytical device on a glass chip that performs a protein sizing assay, by integrating the required separation, staining, virtual destaining, and detection steps. To obtain a universal noncovalent fluorescent label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efc5466b681e29a7d6b5331717c7e24
https://doi.org/10.1021/ac0012492
https://doi.org/10.1021/ac0012492