Výsledky vyhledávání - "Katherine W. Figueroa"

Investigating the interaction of McN-A-343 with the M1 muscarinic receptor using its nitrogen mustard derivative and ACh mustard

Autor: Hinako Suga, Frederick J. Ehlert, Katherine W. Figueroa

Publikováno v: British Journal of Pharmacology. 160:1534-1549

Background and purpose: We investigated how McN-A-343 inhibited the alkylation of the M1 muscarinic receptor by its nitrogen mustard derivative and that of ACh to identify whether it interacts allosterically or orthosterically. Experimental approach:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37a94bbf4c27fb8baa6d436e8f92538e
https://doi.org/10.1111/j.1476-5381.2010.00810.x

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Multilevel Genomic Approach in Pain Research: Basic Science and Clinical Implications

Autor: Z. David Luo, Katherine W. Figueroa

Publikováno v: Reviews in Analgesia. 10:45-58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1dea3b9cb96bc52b453eee0fecf6d34
https://doi.org/10.3727/154296108783994059

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5-Hydroxytryptamine receptor assays

Autor: M. Teresa Pulido-Rios, Katherine W. Figueroa, Graeme R. Martin

Publikováno v: Current Protocols in Pharmacology

5-Hydroxytryptamine (5-HT) receptors, by virtue of their broad expression pattern in peripheral and central tissues, regulate diverse physiological and behavioral responses through the activation of fourteen molecularly distinct receptor subtypes. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f534fc5e6095ca1f475d5f315f2977c
https://pubmed.ncbi.nlm.nih.gov/22294394

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JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability

Autor: Nigel P. Shankley, Clodagh Prendergast, Luc Ver Donck, Lina Li, E. Ghoos, Michele C. Rizzolio, Terrance D. Barrett, Jamie M. Freedman, Magda F. Morton, Katherine W. Figueroa, Laurence Cagnon, Xiaodong Wu, Brett D. Allison, Veronica Moreno, Guy Lagaud, Michael H. Rabinowitz, Jayashree Pyati

Publikováno v: The Journal of pharmacology and experimental therapeutics. 338(1)

JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide] is a representative of a new chemical class of competitive antagonists of cholecystokinin 2 (CCK2) receptors. In this study, the primary in vitro ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dfeb6715e9cb0a54e06d779fe0d75a
https://pubmed.ncbi.nlm.nih.gov/21493750

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One Hundred Years of Histamine Research

Autor: Nigel P. Shankley, Katherine W. Figueroa

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781441980557

In this introductory chapter, we revisit some of the landmarks in the history of histamine research. Since histamine was first synthesized (1907) and isolated as a bacterial contaminant of an extract of ergot (1910), the elucidation of its role in he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9e848bdad1c9c0c72cda810778a0a3e
https://doi.org/10.1007/978-1-4419-8056-4_1

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Selectivity of Agonists for the Active State of M1 to M4 Muscarinic Receptor Subtypes

Autor: Frederick J. Ehlert, Katherine W. Figueroa, Michael T. Griffin

We measured the intrinsic relative activity (RA(i)) of muscarinic agonists to detect possible selectivity for receptor subtypes and signaling pathways. RA(i) is a relative measure of the microscopic affinity constant of an agonist for the active stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9fbc95353304f164ec8a2c2c17899c
https://europepmc.org/articles/PMC2644050/

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Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected]

Autor: Z. David Luo, Doo-sik Kim, Tim Yolo, Katherine W. Figueroa, Amin Boroujerdi, Kang-Wu Li

Publikováno v: Pain. 143(1-2)

To explore cellular changes in sensory neurons after nerve injury and to identify potential target genes contributing to different stages of neuropathic pain development, we used Affymetrix oligo arrays to profile gene expression patterns in L5/6 dor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320a5298a9d60ca64e0c2445c3c14f35
https://pubmed.ncbi.nlm.nih.gov/19307059

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Use of acetylcholine mustard to study allosteric interactions at the M2 muscarinic receptor

Autor: Hinako Suga, Frederick J. Ehlert, Katherine W. Figueroa

We explored the interaction of a nitrogen mustard derivative of acetylcholine with the human M(2) muscarinic receptor expressed in Chinese hamster ovary cells using the muscarinic radioligand, [3H]N-methylscopolamine (NMS). Acetylcholine mustard caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aab52fa5e8f3935b55a3ecc6f5479a3
https://europepmc.org/articles/PMC2677819/

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