Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Katherine W Roche"'
Publikováno v:
eLife, Vol 4 (2015)
Kainate receptors (KARs) are a subfamily of glutamate receptors mediating excitatory synaptic transmission and Neto proteins are recently identified auxiliary subunits for KARs. However, the roles of Neto proteins in the synaptic trafficking of KAR G
Externí odkaz:
https://doaj.org/article/2c34d07d55514bb083c68e838e78a76c
Autor:
Young Ho Suh, Aki Yoshimoto-Furusawa, Karis A Weih, Lino Tessarollo, Katherine W Roche, Susan Mackem, Paul A Roche
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18444 (2011)
SNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SN
Externí odkaz:
https://doaj.org/article/56e16382f6a64aff903d79046d179b26
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Protein–protein interaction networks and signaling complexes are essential for normal brain function and are often dysregulated in neurological disorders. Nevertheless, unraveling neuron- and synapse-specific proteins interaction networks has remai
Externí odkaz:
https://doaj.org/article/583487e37b50432c8497ce2f4ba977a8
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results in social-communication impairments, as well as restricted and repetitive behaviors. Moreover, ASD is more prevalent in males, with a male to female ratio of 4 to 1. Althoug
Externí odkaz:
https://doaj.org/article/224199431d3e4d3b8038777d3221a519
Autor:
Jeremiah D. Paskus, Chen Tian, Erin Fingleton, Christine Shen, Xiaobing Chen, Yan Li, Samuel A. Myers, John D. Badger, II, Michael A. Bemben, Bruce E. Herring, Katherine W. Roche
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2944-2952.e5 (2019)
Summary: The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain
Externí odkaz:
https://doaj.org/article/619034fa4bec4ef59d632deb56145433
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Calcium-calmodulin-dependent protein kinase II (CaMKII) is well known for its roles in synaptic plasticity. Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity
Externí odkaz:
https://doaj.org/article/5fb48f87db034bfe9e462aad3de3908e
Autor:
Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll, Javier Diaz-Alonso
Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and MDGA2) are a family of synaptic organizers suggested to play an unusual rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ca99f368ad139fcfa61e0d6f1fcb49
https://doi.org/10.1101/2023.05.25.542333
https://doi.org/10.1101/2023.05.25.542333
Autor:
Erin Fingleton, Katherine W. Roche
Publikováno v:
Trends in Neurosciences. 46:411-412
Autor:
Xinglong Gu, Xia Mao, Marc P. Lussier, Mary Anne Hutchison, Liang Zhou, F. Kent Hamra, Katherine W. Roche, Wei Lu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new clas
Externí odkaz:
https://doaj.org/article/da577629600d4e19af92086f063fbc57
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The originally published version of this Article contained errors in Figure 5, for which we apologise. In panel c, the scatter graph was inadvertently replaced with a scatter graph comprising a subset of data points from panel d. Furthermore, the leg
Externí odkaz:
https://doaj.org/article/285590a6c6aa43ccbe9bb83ced51b30c