Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Katherine W Roche"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Protein–protein interaction networks and signaling complexes are essential for normal brain function and are often dysregulated in neurological disorders. Nevertheless, unraveling neuron- and synapse-specific proteins interaction networks has remai
Externí odkaz:
https://doaj.org/article/583487e37b50432c8497ce2f4ba977a8
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that results in social-communication impairments, as well as restricted and repetitive behaviors. Moreover, ASD is more prevalent in males, with a male to female ratio of 4 to 1. Althoug
Externí odkaz:
https://doaj.org/article/224199431d3e4d3b8038777d3221a519
Autor:
Jeremiah D. Paskus, Chen Tian, Erin Fingleton, Christine Shen, Xiaobing Chen, Yan Li, Samuel A. Myers, John D. Badger, II, Michael A. Bemben, Bruce E. Herring, Katherine W. Roche
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 2944-2952.e5 (2019)
Summary: The RhoGEFs Kalirin-7 and Trio are regulators of synaptic plasticity, and their dysregulation is associated with a range of neurodevelopmental and neurodegenerative disorders. Although studies have implicated both Kalirin and Trio in certain
Externí odkaz:
https://doaj.org/article/619034fa4bec4ef59d632deb56145433
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Calcium-calmodulin-dependent protein kinase II (CaMKII) is well known for its roles in synaptic plasticity. Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity
Externí odkaz:
https://doaj.org/article/5fb48f87db034bfe9e462aad3de3908e
Autor:
Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll, Javier Diaz-Alonso
Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and MDGA2) are a family of synaptic organizers suggested to play an unusual rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ca99f368ad139fcfa61e0d6f1fcb49
https://doi.org/10.1101/2023.05.25.542333
https://doi.org/10.1101/2023.05.25.542333
Autor:
Erin Fingleton, Katherine W. Roche
Publikováno v:
Trends in Neurosciences. 46:411-412
Autor:
Xinglong Gu, Xia Mao, Marc P. Lussier, Mary Anne Hutchison, Liang Zhou, F. Kent Hamra, Katherine W. Roche, Wei Lu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new clas
Externí odkaz:
https://doaj.org/article/da577629600d4e19af92086f063fbc57
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The originally published version of this Article contained errors in Figure 5, for which we apologise. In panel c, the scatter graph was inadvertently replaced with a scatter graph comprising a subset of data points from panel d. Furthermore, the leg
Externí odkaz:
https://doaj.org/article/285590a6c6aa43ccbe9bb83ced51b30c
Publikováno v:
J Neurosci
We recently identified an autism spectrum disorder/intellectual disability (ASD/ID)-related de novo mutation hotspot in the Rac1-activating GEF1 domain of the protein Trio. Trio is a Rho guanine nucleotide exchange factor (RhoGEF) that is essential f
Publikováno v:
Current Opinion in Neurobiology. 69:93-104
Many genes encoding synaptic proteins are associated with neurodevelopmental disorders (NDDs) such as autism spectrum disorders (ASDs), intellectual disability (ID), and epilepsy. Here we review recent studies on the synaptic effects of disease-assoc