Zobrazeno 1 - 8
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pro vyhledávání: '"Katherine Veleta"'
Publikováno v:
Neuro Oncol
Medulloblastomas in most patients are distinctively sensitive to radiation therapy, but the mechanisms that mediate this sensitivity are unclear. Current treatments still fail 20%-60% of patients with SHH medulloblastoma and can leave survivors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cff140f7288150ec62468ae3d7f2af
https://europepmc.org/articles/PMC8598465/
https://europepmc.org/articles/PMC8598465/
Publikováno v:
Neuro Oncol
Medulloblastomas, unlike other malignant brain tumors, are typically sensitive to radiation therapy (xRT). However, although xRT allows medulloblastoma patients to survive, it can also confer significant long term cognitive sequelae. Understanding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070bdd836f713fd9c678c4e54b5d77f5
https://europepmc.org/articles/PMC6847084/
https://europepmc.org/articles/PMC6847084/
Autor:
Duhyeong Hwang, Benjamin Babcock, Marina Sokolsky-Papkov, Timothy R. Gershon, You-Wen He, Katherine Veleta, Abigail H. Cleveland
Publikováno v:
Cell Death Differ
The tendency of brain cells to undergo apoptosis in response to exogenous events varies across neural development, with apoptotic threshold dependent on proliferation state. Proliferative neural progenitors show a low threshold for apoptosis, while t
Autor:
Timothy R. Gershon, Katherine Veleta
Medulloblastoma is markedly more sensitive to radiation and chemotherapy than other malignant brain tumors. We have previously shown that medulloblastomas radiation sensitivity of depends on the function of the internal apoptosis pathway. We tested w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d8e47ccd8a412d0d8feb4271d7381a
https://europepmc.org/articles/PMC6217661/
https://europepmc.org/articles/PMC6217661/
Publikováno v:
Integrative and Comparative Biology. 54:931-941
Reduced reproduction extends lifespan of females in many animals. To test the effects of reproduction on storage of macronutrients, we block reproductive output in the lubber grasshopper by injecting RNAi against the precursor to egg-yolk protein, vi
Autor:
Hedi Liu, Alyssa B. Stewart, Idoia Garcia, Sean O’Neill, Timothy R. Gershon, Katherine Veleta, Yen-Yu Ian Shih, Joseph R. Merrill, Andrew J. Crowther, Scott E. Williams, Shiyi Li, Kendall J. Lough, Esteban A. Oyarzabal
Publikováno v:
Development.
Alterations in genes that regulate brain size may contribute to both microcephaly and brain tumor formation. Here, we report that Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports t
Autor:
Katherine Veleta, Timothy R. Gershon
Publikováno v:
Neuro-Oncology. 19:iv46-iv46
Medulloblastoma is distinct among malignant brain tumors in being typically sensitive to radiation therapy. We have previously shown that the radiation sensitivity of medulloblastomas depends on the function of the intrinsic apoptosis pathway. We tes
Publikováno v:
Neuro-Oncology. 17:iii32-iii32
Medulloblastoma is markedly more sensitive to radiation and chemotherapy than glioblastoma or PNET, but the underlying mechanisms contributing to this sensitivity remain unknown. Identifying the molecular mechanisms that mediate sensitivity of medull