Výsledky vyhledávání - "Katherine T, Gillette"

PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

Autor: Alejandro Galindo-Tovar, R.I. Hussain, Peter C. M. Molenaar, Kurt A. Krobert, Torsten Christ, Katherine T. Gillette, Finn Olav Levy, Lu Chen, Emanuel Berk, Alberto J. Kaumann, Andreas Engel, Ursula Ravens

Publikováno v: British Journal of Pharmacology. 169:528-538

Background and purpose Phosphodiesterases PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c48d98bab8756efbf8d803fa6b8d8642
https://doi.org/10.1111/bph.12167

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Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

Autor: Torsten Christ, Alberto J. Kaumann, Andreas Engel, Emanuel Berk, Peter C. M. Molenaar, Katherine T. Gillette, Ursula Ravens, Alejandro Galindo-Tovar

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 387(7)

The beta-blockers carvedilol and metoprolol provide important therapeutic strategies for heart failure treatment. Therapy with metoprolol facilitates the control by phosphodiesterase PDE3, but not PDE4, of inotropic effects of catecholamines in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4861bd1f774400bc8018361685feac71
https://pubmed.ncbi.nlm.nih.gov/24668024

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PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

Autor: Peter, Molenaar, Torsten, Christ, Rizwan I, Hussain, Andreas, Engel, Emanuel, Berk, Katherine T, Gillette, Lu, Chen, Alejandro, Galindo-Tovar, Kurt A, Krobert, Ursula, Ravens, Finn Olav, Levy, Alberto J, Kaumann

Publikováno v: British journal of pharmacology. 169(3)

PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3-1 μM) or PDE4 inhibitor rolipr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::270fd12ab13c4a5afafbb8edab5a3f95
https://pubmed.ncbi.nlm.nih.gov/23489196

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