Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Katherine Schuyten"'
Autor:
Ludivine Moine, Bruce N. Rogers, Mark L. Weber, Karen Tse, Sheri L. Snow, Susan E. Drozda, Karen Baker, John A. Lowe, Kevin A. Serpa, Katherine Schuyten, Jennifer E. Davoren, Rong Suobao, Ann S. Wright, Shari L. DeNinno, Michelle Marie Claffey, Allen J. Duplantier, Christopher Ryan Butler, Brian P. Boscoe, Alan J. Clark, Polina Stolyar, Robert J. Mather, Lois K. Chenard, Haojing Rong, Gaurav Arora, Matthew R. Reese, Tammy Whisman, Lei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4941-4944
Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with suc
Autor:
Kari R. Fonseca, Rong Suobao, Bruce M. Bechle, Xinmin Gan, Michelle Marie Claffey, Amy B. Dounay, Jayvardhan Pandit, Edelweiss Evrard, Jamison B. Tuttle, Laura E. Zawadzke, Christine A. Strick, Brian M. Campbell, Katherine Schuyten, Artem G. Evdokimov, Vinod D. Parikh, Marie Anderson, Somraj Ghosh, Matthew R. Reese, James J. Valentine, Hong Wang, Patrick Robert Verhoest, Weldon Horner, Ji-Young Kim, Vanessa Paradis, Laura A. McAllister, Matthew Merrill Hayward, Michelle A. Salafia
Publikováno v:
ACS Medicinal Chemistry Letters. 3:187-192
Kynurenine aminotransferase (KAT) II has been identified as a potential new target for the treatment of cognitive impairment associated with schizophrenia and other psychiatric disorders. Following a high-throughput screen, cyclic hydroxamic acid PF-