Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Katherine Sarlo"'
Autor:
Matt Lynch, Thomas R. Downs, Shyam Kumar, Stefan Pfuhler, Meredith E. Crosby, Tim Mills, Matthew Scott Wagner, Ashley Sullivan, Katherine Sarlo, Ting Hu, Bob Reeder
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 745:38-50
While the collection of genotoxicity data and insights into potential mechanisms of action for nano-sized particulate materials (NPs) are steadily increasing, there is great uncertainty whether current standard assays are suitable to appropriately ch
Autor:
Ninna Willestofte Berg, Francis H Kruszewski, Beth Concoby, David A. Basketter, Katherine Sarlo
Publikováno v:
Journal of Immunotoxicology. 9:314-319
There exists considerable historic experience of the relationship between exposure and both the induction of sensitization and the elicitation of respiratory symptoms from industrial enzymes of bacterial and fungal origin used in a wide variety of de
Autor:
Katherine Sarlo, Beth Concoby, David A. Basketter, Ninna Willestofte Berg, Francis H Kruszewski
Publikováno v:
Journal of Immunotoxicology. 9:320-326
Detergent enzymes have a very good safety profile, with almost no capacity to generate adverse acute or chronic responses in humans. The exceptions are the limited ability of some proteases to produce irritating effects at high concentrations, and th
Publikováno v:
Journal of Immunotoxicology. 8:46-55
1,4-Phenylenediamine (PPD) and the structurally-related 1,4-toluenediamine (PTD) are frequently used oxidative hair dye precursors that can induce a delayed-type hypersensitivity reaction known as contact allergy. Very rare cases of Type 1 (IgE-media
Autor:
Clarence Bohne, Keith Casey, Katherine Sarlo, Charles Fryer, Edwin D. Clark, Mike Kuhn, Karen Blackburn, Janine Anne Flood, Joel G. Chaney, Suzanne Neu, Jeff T. Grothaus, Dana Abbott
Publikováno v:
Toxicology. 263:117-126
Understanding tissue distribution and clearance of nanomaterials following different routes of exposure is needed for risk assessment. F344 female rats received single or multiple exposures to 20 nm, 100 nm or 1000 nm latex fluorospheres by intraveno
Autor:
Gregory M. Adamson, Katherine Sarlo, J. David Innis, Victoria L. Hollis, D. Bruce Kirchner, Laura S. Babcock
Publikováno v:
Journal of Immunotoxicology. 1:71-77
Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-s
Autor:
Jennifer S. Parris, Patricia A. Horn, Edwin D. Clark, Katherine Sarlo, J. Ann McCay, Michael K. Robinson, Vanessa L. Peachee, Kimber L. White, Yvonne L. Veloso
Publikováno v:
Toxicological Sciences. 58:299-305
b/d ), a cross of C57Bl/6 (H-2 b ) 3 DBA/2 (H-2 d ) has been used for most of the development work. Preliminary data in the CB6F1(H-2 d/b ), a cross of Balb/c (H-2 d ) 3 C57Bl/6 showed that this strain was similar to the BDF1 in its response to enzym
Autor:
Rebecca J. Dearman, Nancy I. Kerkvliet, Katherine Sarlo, Ian Kimber, Steve L. Taylor, James D. Astwood
Publikováno v:
Toxicological Sciences. 48:157-162
The ability of exogenous proteins to cause respiratory and gastrointestinal allergy, and sometimes systemic anaphylactic reactions, is well known. What is not clear however, are the properties that confer on proteins the ability to induce allergic se
Autor:
Laura S. Babcock, Katherine Sarlo, Patricia A. Horn, Thomas T. Kawabata, E. Robert Fletcher, Michael K. Robinson
Publikováno v:
Toxicological Sciences. 43:39-46
A mouse intranasal test (MINT) was developed to determine the relative allergenicity of detergent enzymes. In this simple method, various doses of the enzymes are administered in a detergent matrix, via intranasal instillation, on days 1, 3, and 10,
Publikováno v:
Journal of Allergy and Clinical Immunology. 100:480-487
A guinea pig intratracheal test was developed to assess the respiratory allergenicity of enzymes used in the detergent industry. Information gained from this test was used in a process for setting operational exposure guidelines to protect worker hea