Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Katherine S. H. Beckham"'
Autor:
Sonja Staack, Matt D. Johansen, Laura Berneking, Laura Paulowski, Lucia Asar, Nhi Van, Laurent Kremer, Yonatan Degefu, Holger Rohde, Katherine S. H. Beckham, Annabel Parret, Florian P. Maurer, Flor Vásquez Sotomayor, Keith Combrink, Bree B. Aldridge, Martin Aepfelbacher, Matthias Wilmanns
Infections caused byMycobacterium abscessusare difficult to treat due to its intrinsic resistance to most antibiotics. Formation of biofilms and the capacity ofM. abscessusto survive inside host phagocytes further complicate eradication. Herein, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a396a4319ff1ec6fe446cc4031876026
https://doi.org/10.1101/2021.07.12.452042
https://doi.org/10.1101/2021.07.12.452042
Autor:
Mads Gabrielsen, Katherine S H Beckham, Victoria A Feher, Caroline E Zetterström, Dai Wang, Sylke Müller, Mikael Elofsson, Rommie E Amaro, Olwyn Byron, Andrew J Roe
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32217 (2012)
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced sta
Externí odkaz:
https://doaj.org/article/f1d1bcf768034b47ad2805c83446d23a
Autor:
Jayde A Gawthorne, L Evan Reddick, Snezhana N Akpunarlieva, Katherine S H Beckham, John M Christie, Neal M Alto, Mads Gabrielsen, Andrew J Roe
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52962 (2012)
In this work, we describe the utility of Light, Oxygen, or Voltage-sensing (LOV) flavoprotein domains from plant phototropins as a reporter for protein expression and function. Specifically, we used iLOV, an enhanced and more photostable variant of L
Externí odkaz:
https://doaj.org/article/e4119eba0a0a4a3eaec859a4c3afe9bd
Publikováno v:
Progress in biophysics and molecular biology. 152
Tuberculosis (TB) remains the foremost cause of death by infectious disease and is propagated by the pathogen Mycobacterium tuberculosis (Mtb). The virulence associated with Mtb is mediated by proteins secreted into host cells by the type VII secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2968927d0270b5af6ba3cbc2fdc9e7
https://pubmed.ncbi.nlm.nih.gov/31765647
https://pubmed.ncbi.nlm.nih.gov/31765647
Autor:
Katherine S. H. Beckham, Wolfgang Lugmayr, Annabel H. A. Parret, Edith N.G. Houben, Mandy Rettel, Matthias Wilmanns, Dmitri I. Svergun, Thomas C. Marlovits, Haydyn D. T. Mertens, Mikhail M. Savitski, Luciano Ciccarelli, Catalin M. Bunduc, Roy Ummels, Wilbert Bitter, Julia Mayr
Publikováno v:
Beckham, K S H, Ciccarelli, L, Bunduc, C M, Mertens, H D T, Ummels, R, Lugmayr, W, Mayr, J, Rettel, M, Savitski, M M, Svergun, D I, Bitter, W, Wilmanns, M, Marlovits, T C, Parret, A H A & Houben, E N G 2017, ' Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis ', Nature Microbiology, vol. 2, pp. 17047 . https://doi.org/10.1038/nmicrobiol.2017.47
Nature Microbiology, 2. Nature Publishing Group
Nature microbiology 2, 17047 (2017). doi:10.1038/nmicrobiol.2017.47
Beckham, K S H, Ciccarelli, L, Bunduc, C M, Mertens, H D T, Ummels, R, Lugmayr, W, Mayr, J, Rettel, M, Savitski, M M, Svergun, D I, Bitter, W, Wilmanns, M, Marlovits, T C, Parret, A H A & Houben, E N G 2017, ' Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis ', NATURE MICROBIOLOGY, vol. 2, no. 6, 17047 . https://doi.org/10.1038/nmicrobiol.2017.47
NATURE MICROBIOLOGY, 2(6):17047. Nature Publishing Group
Nature Microbiology, 2. Nature Publishing Group
Nature microbiology 2, 17047 (2017). doi:10.1038/nmicrobiol.2017.47
Beckham, K S H, Ciccarelli, L, Bunduc, C M, Mertens, H D T, Ummels, R, Lugmayr, W, Mayr, J, Rettel, M, Savitski, M M, Svergun, D I, Bitter, W, Wilmanns, M, Marlovits, T C, Parret, A H A & Houben, E N G 2017, ' Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis ', NATURE MICROBIOLOGY, vol. 2, no. 6, 17047 . https://doi.org/10.1038/nmicrobiol.2017.47
NATURE MICROBIOLOGY, 2(6):17047. Nature Publishing Group
Nature microbiology 2, 17047 (2017). doi:10.1038/nmicrobiol.2017.47
Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids$^1$. To transport substrates across this complex cell envelope, mycobacteria r
Mycobacteria are characterized by their impermeable outer membrane, which is rich in mycolic acids$^1$. To transport substrates across this complex cell envelope, mycobacteria r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c336a8231d31af8d816e663a0fe57310
https://research.vumc.nl/en/publications/5def332a-3c4e-44cd-9da1-425f5c494d8b
https://research.vumc.nl/en/publications/5def332a-3c4e-44cd-9da1-425f5c494d8b
Autor:
Anna Grabowska, Michele Cianci, André Colom, Thomas R. Schneider, Dirk Schnappinger, Annabel H. A. Parret, Terezie Panikova, Luiz Pedro S. de Carvalho, Vivian Pogenberg, Claude Gutierrez, Olivier Neyrolles, Katherine S. H. Beckham, Kanchiyaphat Ariyachaokun, Pierre Genevaux, Laure Botella, Yves-Marie Boudehen, Acely Garza-Garcia, Anne Tuukkanen, Dmitri I. Svergun, Diana Freire, Matthias Wilmanns, Ambre Sala, Antonio Peixoto
Publikováno v:
Molecular Cell
Molecular cell 73(6), 1282-1291.e8 (2019). doi:10.1016/j.molcel.2019.01.028
Molecular Cell, Elsevier, 2019, 73 (6), pp.1282-1291.e8. ⟨10.1016/j.molcel.2019.01.028⟩
Molecular cell 73(6), 1282-1291.e8 (2019). doi:10.1016/j.molcel.2019.01.028
Molecular Cell, Elsevier, 2019, 73 (6), pp.1282-1291.e8. ⟨10.1016/j.molcel.2019.01.028⟩
Summary Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c417031894e3e2203c7666925887a823
http://europepmc.org/articles/PMC6436930
http://europepmc.org/articles/PMC6436930
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 68:522-526
Thiol peroxidase (Tpx) is an atypical 2-Cys peroxiredoxin, which has been suggested to be important for cell survival and virulence in Gram-negative pathogens. The structure of a catalytically inactive version of this protein in an orthorhombic cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe908b44370fe77cb97770796c6df27b
https://doi.org/10.1107/s1744309112011487
https://doi.org/10.1107/s1744309112011487
Autor:
Timothy J. Mitchell, Andrew J. Roe, Hanna Uvell, Arvind Mahajan, Mads Gabrielsen, Dai Wang, Olwyn Byron, Richard Burchmore, Katherine S. H. Beckham, Sarah MacDonald, Caroline E. Zetterström, Pawel Herzyk, Brian O. Smith, Mikael Elofsson, Jai J. Tree, David L. Gally
Publikováno v:
The Journal of Biological Chemistry
Wang, D, Zetterstrom, C E, Gabrielsen, M, Beckham, K S, Tree, J J, Macdonald, S E, Byron, O, Mitchell, T J, Gally, D L, Herzyk, P, Mahajan, A, Uvell, H, Burchmore, R, Smith, B O, Elofsson, M & Roe, A J 2011, ' Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds ', Journal of Biological Chemistry, vol. 286, no. 34, pp. 29922-29931 . https://doi.org/10.1074/jbc.M111.233858
Wang, D, Zetterstrom, C E, Gabrielsen, M, Beckham, K S, Tree, J J, Macdonald, S E, Byron, O, Mitchell, T J, Gally, D L, Herzyk, P, Mahajan, A, Uvell, H, Burchmore, R, Smith, B O, Elofsson, M & Roe, A J 2011, ' Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence blocking compounds ', Journal of Biological Chemistry, vol. 286, no. 34, pp. 29922-29931 . https://doi.org/10.1074/jbc.M111.233858
A class of anti-virulence compounds, the salicylidene acylhydrazides, have been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work, we provide th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b5dceeb19b39bc22b7f81bc5ef1953
http://europepmc.org/articles/PMC3191033
http://europepmc.org/articles/PMC3191033
Autor:
Dai Wang, Neil W. Isaacs, Andrew J. Roe, Caroline E. Zetterström, Katherine S. H. Beckham, Mikael Elofsson, Mads Gabrielsen
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:1606-1609
Thiol peroxidase is an atypical 2-Cys peroxiredoxin that reduces alkyl hydroperoxides. Wild-type and C61S mutant protein have been recombinantly expressed in Escherichia coli and purified using nickel-affinity chromatography. Initial crystallization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb99049ea701055ea3a37789b4ea670
https://doi.org/10.1107/s1744309110039679
https://doi.org/10.1107/s1744309110039679
Publikováno v:
Protein Expression and Purification. 71:184-189
The formate–nitrite transporter family is composed of integral membrane proteins that possess six to eight α-helical transmembrane domains. Genes encoding these proteins are observed widely in prokaryotic genomes as well as certain groups of lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6653feb6789495fbbc32eab45d69ab6b
https://doi.org/10.1016/j.pep.2009.12.005
https://doi.org/10.1016/j.pep.2009.12.005