Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Katherine R. Mariner"'
Autor:
Katherine R. Mariner, Ian Chopra, Janez Konc, Alex J. O'Neill, Blaž Vehar, Martina Hrast, Stanislav Gobec, Andreja Kovač, Dušanka Janežič
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5137-5146
d -Alanine: d -alanine ligase (Ddl), an intracellular bacterial enzyme essential for cell wall biosynthesis, is an attractive target for development of novel antimicrobial drugs. This study focused on an extensive evaluation of two families of Ddl in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1752c30460889ee451f781199c8cdf02
https://doi.org/10.1016/j.bmc.2011.07.020
https://doi.org/10.1016/j.bmc.2011.07.020
Autor:
Katherine R. Mariner, Rachel Trowbridge, Colin W. G. Fishwick, Alex J. O'Neill, Ian Chopra, Martin J. McPhillie, A. Peter Johnson
Publikováno v:
ACS Medicinal Chemistry Letters. 2:729-734
Bacterial RNA polymerase (RNAP) is essential for transcription and is an antibacterial target for small molecule inhibitors. The binding region of myxopyronin B (MyxB), a bacterial RNAP inhibitor, offers the possibility of new inhibitor design. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f841a0049f6ef9232384da1b82497d
https://doi.org/10.1021/ml200087m
https://doi.org/10.1021/ml200087m
Autor:
Martin J. McPhillie, Katherine R. Mariner, Rachel Trowbridge, Catriona Smith, Alex J. O'Neill, Ian Chopra, Colin W. G. Fishwick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:2413-2416
We explored the properties of corallopyronin A (CorA), a poorly characterized inhibitor of bacterial RNA polymerase (RNAP). It displayed a 50% inhibitory concentration of 0.73 μM against RNAP, compared with 11.5 nM for rifampin. The antibacterial ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee45978e903075238b538c3af9807a3
https://doi.org/10.1128/aac.01742-10
https://doi.org/10.1128/aac.01742-10
Autor:
Martine Nguyen-Distèche, Nick K. Olrichs, Ana Maria Amoroso, Samo Turk, Jean-Marie Frère, Bernard Joris, Julieanne M. Bostock, Ian Chopra, Julien Offant, Katherine R. Mariner, Eefjan Breukink, Stanislav Gobec, Thierry Vernet, Adeline Derouaux, Mohammed Terrak, Astrid Zervosen
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1098. ⟨10.1016/j.bcp.2011.02.008⟩
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1098. ⟨10.1016/j.bcp.2011.02.008⟩
International audience; Bacterial peptidoglycan glycosyltransferases (GTs) of family 51 catalyze the polymerization of the lipid II precursor into linear peptidoglycan strands. This activity is essential to bacteria and represents a validated target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55834dee6b61204793b307e3fa63e73a
https://doi.org/10.1016/j.bcp.2011.02.008
https://doi.org/10.1016/j.bcp.2011.02.008
Autor:
Ian Chopra, Colin W. G. Fishwick, Katherine R. Mariner, Rachel Trowbridge, Keith W. Miller, Alex J. O'Neill, Anil Agarwal
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:4506-4509
Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f3232e0cfd94c7216d206f69bb8fb0
https://doi.org/10.1128/aac.00753-10
https://doi.org/10.1128/aac.00753-10
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:637-639
Antistaphylococcal agents commonly lack activity against Gram-negative bacteria like Escherichia coli owing to the permeability barrier presented by the outer membrane and/or the action of efflux transporters. When these intrinsic resistance mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dc1a0d89ae2e4965d40fa55fc74595
https://doi.org/10.1128/aac.02005-12
https://doi.org/10.1128/aac.02005-12
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:1784-1786
We further examined the usefulness of previously reported Bacillus subtilis biosensors for antibacterial mode-of-action studies. The biosensors could not detect the tRNA synthetase inhibitors mupirocin, indolmycin, and borrelidin, some inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6f6774321e075d08204c75a31e2b4d
https://doi.org/10.1128/aac.01710-10
https://doi.org/10.1128/aac.01710-10