Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katherine R Mattaini"'
Autor:
Jude Alsarraj, Farhoud Faraji, Thomas R Geiger, Katherine R Mattaini, Mia Williams, Josephine Wu, Ngoc-Han Ha, Tyler Merlino, Renard C Walker, Allen D Bosley, Zhen Xiao, Thorkell Andresson, Dominic Esposito, Nicholas Smithers, Dave Lugo, Rab Prinjha, Anup Day, Nigel P S Crawford, Keiko Ozato, Kevin Gardner, Kent W Hunter
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80746 (2013)
Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target of BET inhibitors, encodes two isofo
Externí odkaz:
https://doaj.org/article/c2c9aa744b3a4146a566e38515814caa
Autor:
Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson, Matthew G. Vander Heiden
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods In order to study the effect o
Externí odkaz:
https://doaj.org/article/3c3135e5d5674410bb51cf7b8aa97abe
Autor:
Allison N. Lau, Roderick T. Bronson, Matthew G. Vander Heiden, Katherine R. Mattaini, Mark R. Sullivan, Brian P. Fiske
Publikováno v:
BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods In order to study the effect of increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236bed89a9d6b9008901850d85390c90
https://doi.org/10.1186/s12885-019-5933-5
https://doi.org/10.1186/s12885-019-5933-5
Publikováno v:
Rockefeller University Press
The Journal of Cell Biology
The Journal of Cell Biology
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19470143389f20c62189b76da795ef24
https://doi.org/10.1083/jcb.201604085
https://doi.org/10.1083/jcb.201604085
Autor:
Emily A Dennstedt, Anna A. Nguyen, Alexander Muir, Mark R. Sullivan, Sharanya Sivanand, Alicia M. Darnell, Katherine R. Mattaini, Marcus Bosenberg, Katrina Meeth, Caroline A. Lewis, Matthew G. Vander Heiden, Montana F. Reilly
Publikováno v:
Cell Metab
PMC
PMC
Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number gain of the gene encoding the first enzyme in the pathway, phosphoglycerate dehy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bfebc95e381fe8444a937d19591faf
https://pubmed.ncbi.nlm.nih.gov/30905671
https://pubmed.ncbi.nlm.nih.gov/30905671
Autor:
Mark R. Sullivan, Brian P. Fiske, Katherine R. Mattaini, Roderick T. Bronson, Matthew G. Vander Heiden, Allison N. Lau
SUMMARYCopy number gain of thePHGDHgene that encodes the first enzyme of the serine biosynthesis pathway is found in some human cancers, including a subset of melanomas. In order to study the effect of increasedPHGDHexpression in tissuesin vivo, we g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89bd7bb8e6586a594b585e9c186b35f
https://doi.org/10.1101/249250
https://doi.org/10.1101/249250
Autor:
Jing Fan, Matthew G. Vander Heiden, Katherine R. Mattaini, Ryan E. Looper, Ling Liu, Xin Teng, Joshua D. Rabinowitz
Publikováno v:
ACS Chemical Biology
Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c863e65546925401ddbcfd77167384b
https://doi.org/10.1021/cb500683c
https://doi.org/10.1021/cb500683c
Autor:
Katherine R. Mattaini, Edouard Mullarky, Lewis C. Cantley, Jason W. Locasale, Matthew G. Vander Heiden
Publikováno v:
Pigment Cell & Melanoma Research. 24:1112-1115
The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bcd15265795ce3d37c66488ba309df
https://doi.org/10.1111/j.1755-148x.2011.00919.x
https://doi.org/10.1111/j.1755-148x.2011.00919.x
Autor:
Natalie I. Vokes, Katherine R. Mattaini, Christian M. Metallo, William J. Israelsen, M. G. Vander Heiden, Jason W. Locasale, Brian P. Fiske, Gregory Stephanopoulos, Lewis C. Cantley, Sophia Y. Lunt, Talya L. Dayton
Publikováno v:
Vander Heiden via Courtney Crummett
Proliferating cells adapt metabolism to support the conversion of available nutrients into biomass. How cell metabolism is regulated to balance the production of ATP, metabolite building blocks, and reducing equivalents remains uncertain. Proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c3d82c59f4b630fefae1e3cbf2ca24
https://doi.org/10.1101/sqb.2012.76.010900
https://doi.org/10.1101/sqb.2012.76.010900
Autor:
Matthew G. Vander Heiden, Brian P. Fiske, Shawn M. Davidson, Mitali Kini, Katherine R. Mattaini, Edward J. Brignole, Catherine L. Drennan
Publikováno v:
Cancer & Metabolism
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b061803c282d921a66571ef716c8b6f
https://pubmed.ncbi.nlm.nih.gov/25926973
https://pubmed.ncbi.nlm.nih.gov/25926973