Výsledky vyhledávání - "Katherine R, Heberlein"

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

Autor: Mohammad Mahfuzul Haque, Brant E. Isakson, Mauro Siragusa, Katherine R. Heberlein, William C. Sessa, Dennis J. Stuehr, Jonathan V. Pascale, Victor Garcia, Eon Joo Park, Florian Fröhlich

Publikováno v: Proc Natl Acad Sci U S A

Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a critical mediator of vascular function. eNOS is tightly regulated at various levels, including transcription, co- and posttranslational modifications, and by various protein-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35609f9b3086ed7af6449719637665b6
https://doi.org/10.1073/pnas.1918761117

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A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction

Autor: Brant E. Isakson, Katherine R. Heberlein, Angela K. Best, Christoph Kaun, Adam C. Straub, Jenny E. Han, Johann Wojta

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 32:1271-1279

Objective— Plasminogen activator inhibitor-1 (PAI-1) has previously been shown to be key to the formation of myoendothelial junctions (MEJs) in normal and pathological states (eg, obesity). We therefore sought to identify the mechanism whereby PAI-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df497addf3548989b0aff907a113b848
https://doi.org/10.1161/atvbaha.112.246371

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A New Method for In Vivo Visualization of Vessel Remodeling Using a Near-Infrared Dye

Autor: Anthony C. Bruce, Mark A. Greyson, Scott A. Seaman, Jeremy A. Ross, Jenny Han, Shayn M. Peirce, Brant E. Isakson, Katherine R. Heberlein, Marie Billaud, Angela K. Best

Publikováno v: Microcirculation. 18:163-171

Please cite this paper as: Billaud, Ross, Greyson, Bruce, Seaman, Heberlein, Han, Best, Peirce and Isakson (2011). A New Method for In Vivo Visualization of Vessel Remodeling Using a Near-Infrared Dye. Microcirculation 18(3), 163–171. Abstract Obje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06dc4def1ec4d94ede37010583558e56
https://doi.org/10.1111/j.1549-8719.2011.00085.x

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A new method for in vivo visualization of vessel remodeling using a near-infrared dye

Autor: Marie, Billaud, Jeremy A, Ross, Mark A, Greyson, Anthony C, Bruce, Scott A, Seaman, Katherine R, Heberlein, Jenny, Han, Angela K, Best, Shayn M, Peirce, Brant E, Isakson

Publikováno v: Microcirculation (New York, N.Y. : 1994). 18(3)

Vascular obstructive events can be partially compensated for by remodeling processes that increase vessel diameter and collateral tortuosity. However, methods for visualizing remodeling events in vivo and with temporal comparisons from the same anima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1465bbb425ad9032ccbb6c31bf72d227
https://pubmed.ncbi.nlm.nih.gov/21418375

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Plasminogen activator inhibitor-1 regulates myoendothelial junction formation

Autor: Norbert Leitinger, Katherine R. Heberlein, Angela K. Best, Robin Looft-Wilson, Brant E. Isakson, Adam C. Straub, Poonam Sharma, Akshaya K. Meher, Mark A. Greyson

Rationale : Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular disease states; however, its target of action within the vessel wall is undefined. Objective : Determine the ability of PAI-1 to regulate myoendothelial junctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a4dc1a0d0de1042b5e7968013bb2a9
https://europepmc.org/articles/PMC2848897/

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Site-specific connexin phosphorylation is associated with reduced heterocellular communication between smooth muscle and endothelium

Autor: Michael J. Rizzo, Katherine R. Heberlein, Adam C. Straub, Angela K. Best, Scott Boitano, Brant E. Isakson, Scott R. Johnstone

Publikováno v: Journal of vascular research. 47(4)

Background/Aims: Myoendothelial junctions (MEJs) represent a specialized signaling domain between vascular smooth muscle cells (VSMC) and endothelial cells (EC). The functional consequences of phosphorylation state of the connexins (Cx) at the MEJ ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2293ceec985c675015295bea3a0bcd2a
https://pubmed.ncbi.nlm.nih.gov/20016202

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