Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katherine Pohl"'
Autor:
Vivian Y. Chang, Yuwei He, Samantha Grohe, Morgan R. Brady, Aldi Chan, Rucha S. Kadam, Tiancheng Fang, Amara Pang, Katherine Pohl, Evelyn Tran, Michelle Li, Jenny Kan, Yurun Zhang, Josie J. Lu, Joshua P. Sasine, Heather A. Himburg, Peibin Yue, John P. Chute
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110306- (2024)
Summary: Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid sk
Externí odkaz:
https://doaj.org/article/c1457d4f4fb74ff7af820506ba0c3075
Autor:
Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoi
Externí odkaz:
https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
Autor:
Xiao Yan, Heather A. Himburg, Katherine Pohl, Mamle Quarmyne, Evelyn Tran, Yurun Zhang, Tiancheng Fang, Jenny Kan, Nelson J. Chao, Liman Zhao, Phuong L. Doan, John P. Chute
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1584-1594 (2016)
Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hema
Externí odkaz:
https://doaj.org/article/a87fd976b98a4dc39d648d93607105b6
Autor:
Yurun Zhang, Tiancheng Fang, Katherine Pohl, Martina Roos, John P. Chute, Peter A. Scott, Anna Patricia L. Javier, Vivian Y. Chang, Paulina K. Lin, Amara Pang, Christina M. Termini, Heather A. Himburg, Xiao Yan, Liman Zhao, Lia Signaevskaia, Mamle Quarmyne, Jenny Kan
Publikováno v:
Blood
Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant transformation over time. Extrinsic regulation of HSC DNA repair is not well understood, and therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f57c1b35fce4e9e1cfbbb26c5d3f6b
https://doi.org/10.1182/blood.2020005895
https://doi.org/10.1182/blood.2020005895
Autor:
Michelle Li, Liman Zhao, Heather A. Himburg, Tiancheng Fang, Yurun Zhang, Katherine Pohl, Martina Roos, Christina M. Termini, William H. McBride, Mamle Quarmyne, Robert Damoiseaux, Hyo Jin Gim, Michael E. Jung, Xiao Yan, John P. Chute, Julian P. Whitelegge, Emelyne Diers, Jenny Kan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ce2ccfb97329a8c01e40b8d756036f
https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
Autor:
Tiancheng Fang, Jenny Kan, Yurun Zhang, Katherine Pohl, John P. Chute, Mamle Quarmyne, Heather A. Himburg, Nelson J. Chao, Evelyn Tran, Phuong L. Doan, Xiao Yan, Liman Zhao
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1584-1594 (2016)
SummaryImprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe37da93c60ec710a2a9507a438eef0b
https://doi.org/10.1016/j.celrep.2016.10.025
https://doi.org/10.1016/j.celrep.2016.10.025
Autor:
Katherine Pohl
Publikováno v:
Repositório Institucional da UFU
Universidade Federal de Uberlândia (UFU)
instacron:UFU
Universidade Federal de Uberlândia (UFU)
instacron:UFU
FAPEMIG - Fundação de Amparo a Pesquisa do Estado de Minas Gerais Este estudo teve o objetivo de analisar o corpo enquanto lócus de expressão do sofrimento psíquico após a vivência de uma experiência traumática como a violência sexual inces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da49ffe5570e874430eea7d1aa25b7d
https://doi.org/10.14393/ufu.di.2018.737
https://doi.org/10.14393/ufu.di.2018.737
Autor:
John P. Chute, Katherine Pohl, Xiao Yan, Liman Zhao, Joshua P. Sasine, Nelson J. Chao, Heather A. Himburg, Jeffrey R. Harris, Evelyn Tran, Mamle Quarmyne, Jenny Kan, Phuong L. Doan, Grace V. Hancock
The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known as Sp7 transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa1dfa0bce276f2b9162ecf7c7747ac
https://europepmc.org/articles/PMC5592969/
https://europepmc.org/articles/PMC5592969/
Autor:
Vivian Y. Chang, John P. Chute, Heather A. Himburg, Katherine Pohl, Tiancheng Fang, Evelyn Tran
Publikováno v:
Blood. 132:1284-1284
Aging hematopoietic stem cells display distinct abnormalities such as myeloid skewing, decreased repopulating capacity, and leukemia predisposition. Radiation exposure potentiates aging of the hematopoietic system, as evidenced by premature and persi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6872f51f28b546ac8ac0f7600109e201
https://doi.org/10.1182/blood-2018-99-119929
https://doi.org/10.1182/blood-2018-99-119929
Autor:
John P. Chute, Katherine Pohl, John M. Timmerman, Jenny Kan, Dennis J. Slamon, Christina M. Termini, Hyung Chan Suh
Publikováno v:
Blood. 132:3693-3693
Background: The combination of antigen recognition, costimulatory ligands, and dendritic cells (DC)-derived cytokines (IL-12 or type I IFNs) stimulate T cells upon antigen presentation of DC. Chimeric antigen receptor (CAR) T cells induce anti-tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7e56ee92c940a28160f704ea997a66
https://doi.org/10.1182/blood-2018-99-115296
https://doi.org/10.1182/blood-2018-99-115296