Výsledky vyhledávání - "Katherine Paweletz"

Combination of AMG 160, a PSMA x CD3 half-life extended bispecific T-cell engager (HLE BiTE) immune therapy, with an anti-PD-1 antibody in prostate cancer (PCa)

Autor: Katherine Paweletz, Shyun Li, Gloria Juan, Julie M. Bailis

Publikováno v: Journal of Clinical Oncology. 38:155-155

155 Background: AMG 160 is an HLE BiTE immune therapy that binds prostate-specific membrane antigen (PSMA) on tumor cells and CD3 on T cells, leading to T cell activation, cytokine production, and tumor cell lysis. A phase 1 study of AMG 160 in patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ed3eb9b3c361c5bd791d0acee8ab504
https://doi.org/10.1200/jco.2020.38.6_suppl.155

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Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells

Autor: Ian McCaffery, Susan Swift, Stephen Kaufman, C. Glenn Begley, Leigh Busse, Liqin Liu, Steven G. Elliott, Angus M. Sinclair, Angela Coxon, Katherine Paweletz

Publikováno v: Blood. 115:4264-4272

Erythropoiesis stimulating agents (ESAs) have been reported to activate erythropoietin receptors (EpoR) on cell types, including endothelial, neuronal, renal tubule, and cardiac cells. ESAs have also been reported to promote angiogenesis. However, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff7ee318963a003e593a8ba6c1a8326
https://doi.org/10.1182/blood-2009-10-248666

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A novel MHC- dextramer assay to identify melanoma antigen-specific CD8+ T cells from solid tumor disaggregates and matched peripheral blood

Autor: Katherine Paweletz, Shen-Wu Wang, Robert D. Loberg, Gloria Juan, Michael Chastain

Publikováno v: Journal for Immunotherapy of Cancer

Meeting abstracts Cytotoxic CD8+ T lymphocytes (CTL) mediate target cell killing of tumor cells. New technological advances in multi-parameter flow cytometry have enabled the detection and enumeration of antigen-specific CD8+ T cells (MHC-class I dex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e102081ed6967dab9419cce97b89a6
https://doi.org/10.1186/2051-1426-3-s2-p109

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Abstract 439: Detection of aurora kinase A (AURKA) focal amplification in plasma samples of patients with recurrent ovarian cancer

Autor: Robert D. Loberg, Katherine Paweletz, Abraham Anderson, Gregory Friberg, Florian D. Vogl, Erick Gamelin, Gloria Juan

Publikováno v: Cancer Research. 76:439-439

Purpose: Aurora kinases are associated with acquired resistance to therapy in human cancers. We hypothesized that AURKA amplification is a late event in ovarian cancer (OC) progression and that frequency of amplification might be underestimated if as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6f4d6dafce852a1f7982420281cc225
https://doi.org/10.1158/1538-7445.am2016-439

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Population pharmacokinetic/pharmacodynamic model of subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity after oral administration of AMG 221, a selective 11β-HSD1 inhibitor

Autor: Minghan Wang, John M. Rossi, Maurice Emery, Edgar Bautista, Oranee Daniels, Riccardo Perfetti, Katherine Paweletz, Anna Akrami, Marc R. Gastonguay, Megan A. Gibbs, John P. Gibbs, Ian McCaffery, Brian H. Smith

Publikováno v: Journal of clinical pharmacology. 51(6)

Inhibition of 11β-HSD1 is hypothesized to improve measures of insulin sensitivity and hepatic glucose output in patients with type II diabetes. AMG 221 is a potent, small molecule inhibitor of 11β-HSD1. The objective of this analysis is to describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da846414264d2b07c0e98e38cd4caf8
https://pubmed.ncbi.nlm.nih.gov/20663992

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Functional EpoR Pathway Utilization Is Not Detected in Primary Tumor Cells Isolated from Human Breast, Non-Small Cell Lung, Colorectal, and Ovarian Tumor Tissues

Autor: Katherine Paweletz, Leigh Busse, C. Glenn Begley, Ian McCaffery, V. Dan Fitzpatrick, Scott D. Patterson, Steve Elliott, John M. Rossi

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0122149 (2015)
PLoS ONE

Several clinical trials in oncology have reported increased mortality or disease progression associated with erythropoiesis-stimulating agents. One hypothesis proposes that erythropoiesis-stimulating agents directly stimulate tumor proliferation and/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0286d23469c1fcbbd916f948b5128bf7
https://doi.org/10.1371/journal.pone.0122149

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Abstract 1105: Redundancy of growth factor utilization and complex molecular analyses in human primary tumors highlights potential resistance mechanisms for targeted agents

Autor: John Rossi, Robert D. Loberg, Michael B. Bass, Chetan Deshpande, Dan Baker, Maha Rizk, Katherine Paweletz, Michael A. Damore, Scott D. Patterson, Ian McCaffery

Publikováno v: Cancer Research. 73:1105-1105

Redundancy in growth factor (GF) pathway utilization in human tumors has been hypothesized to be a primary resistance mechanism to targeted therapeutics. Little evidence has been reported in primary tumors to demonstrate functional differences betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::348b690cb64a98dc80f4ddd4edb48944
https://doi.org/10.1158/1538-7445.am2013-1105

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Megakaryocytes Do Not Express Erythropoietin Receptor (EpoR) and Do Not Respond to Recombinant Human Erythropoietin (rHuEpo) Stimulation

Autor: Raffi Manoukian, Katherine Paweletz, Shen-Wu Wang, John M. Rossi, Robert D. Loberg, Beate Sable, Yanyan Tudor, Ian McCaffery, Scott D. Patterson

Publikováno v: Blood. 118:4783-4783

Abstract 4783 Recently, clinical studies were conducted in chronic kidney disease of type 2 diabetes patients that suggested an increased risk of stroke in patients receiving Erythropoiesis Stimulating Agents (ESAs) compared to placebo. One proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab95dd0013f2d3f294e3798d6588c175
https://doi.org/10.1182/blood.v118.21.4783.4783

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Epor Is Not Expressed or Functional in Primary Tumor Cells Isolated Directly From Human Primary and Metastatic Epithelial Tumors Including Breast, Non-Small Cell Lung, Colorectal, and Ovarian Tissues

Autor: Ian McCaffery, Scott D. Patterson, V. Dan Fitzpatrick, Katherine Paweletz, Steve Elliott, Yanyan Tudor, C. Glenn Begley, John M. Rossi

Publikováno v: Blood. 118:4781-4781

Abstract 4781 Several clinical trials have reported increased mortality or disease progression associated with erythropoiesis-stimulating agents (ESA) in patients with cancer. One hypothesis proposes that ESAs stimulate tumor proliferation and or sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474529bc8d73b22ca0f150c0469127d9
https://doi.org/10.1182/blood.v118.21.4781.4781

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Analysis of cell surface erythropoietin receptor (EpoR) expression and function in human epithelial tumor tissues

Autor: Ian McCaffery, Scott D. Patterson, Steven G. Elliott, Yanyan Tudor, Katherine Paweletz, John M. Rossi, V. D. Fitzpatrick

Publikováno v: Journal of Clinical Oncology. 27:11104-11104

11104 Background: EpoR mRNA and protein expression have been reported at low levels in human tumors implying EpoR may be functional in tumor cells with inferred implications for the use of erythropoiesis stimulating agents in the Oncology setting. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d312ecf288fae30e8759cf47ed4bf15
https://doi.org/10.1200/jco.2009.27.15_suppl.11104

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