Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katherine N. Choe"'
Autor:
Xiao-Feng Zheng, Sanket S. Acharya, Katherine N. Choe, Kumar Nikhil, Guillaume Adelmant, Shakti Ranjan Satapathy, Samanta Sharma, Keith Viccaro, Sandeep Rana, Amarnath Natarajan, Peter Sicinski, Jarrod A. Marto, Kavita Shah, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Regulation of post translational modification of 53BP1 is critical for genome integrity and regulation of DNA damage response. Here the authors reveal a CDK5-PP4 phospho-signaling cascade that leads 53BP1 to sites of DNA damage.
Externí odkaz:
https://doaj.org/article/2c564c99951247baadb473f227a8cb95
Publikováno v:
Molecular Cell. 65:380-392
Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d6ec46375a3cf78b01c183320807f9
https://doi.org/10.1016/j.molcel.2016.12.020
https://doi.org/10.1016/j.molcel.2016.12.020
Autor:
Guillaume Adelmant, Kavita Shah, Peter Sicinski, Shakti Ranjan Satapathy, Sanket S. Acharya, Dipanjan Chowdhury, Keith Viccaro, Kumar Nikhil, Katherine N. Choe, Amarnath Natarajan, Sandeep Rana, Xiaofeng Zheng, Jarrod A. Marto, Samanta Sharma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a53d1c7a234c2702cc545903b8bcea
https://doi.org/10.1038/s41467-019-12084-x
https://doi.org/10.1038/s41467-019-12084-x
Autor:
Georgios I. Karras, Subhajyoti De, Claudia M. Nicolae, Alexander H.S. Vlahos, Katherine N. Choe, George Lucian Moldovan, Erin R. Aho
Publikováno v:
Journal of Biological Chemistry. 289:13627-13637
All cells rely on genomic stability mechanisms to protect against DNA alterations. PCNA is a master regulator of DNA replication and S-phase-coupled repair. PCNA post-translational modifications by ubiquitination and SUMOylation dictate how cells sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151e90cfb4d40de059abe52ec9a4041f
https://doi.org/10.1074/jbc.m114.556340
https://doi.org/10.1074/jbc.m114.556340
Autor:
George Lucian Moldovan, Katherine N. Choe, Claudia M. Nicolae, Subhajyoti De, Veronique A. J. Smits, Raimundo Freire, Maria Rocio Delgado‐Diaz, Yuka Imamura Kawasawa, Daniel Constantin
Publikováno v:
EMBO reports. 17(6)
Defects in DNA replication, DNA damage response, and DNA repair compromise genomic stability and promote cancer development. In particular, unrepaired DNA lesions can arrest the progression of the DNA replication machinery during S‐phase, causing r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2800c0e749446f5388749bf99502fc39
https://pubmed.ncbi.nlm.nih.gov/27146074
https://pubmed.ncbi.nlm.nih.gov/27146074
Autor:
Ashley L. Colledge, Shen Shu Sung, Jong K. Yun, Vijay P. Kale, Jeremy A. Hengst, Katherine N. Choe, Yoshinori Takahashi, Taryn E. Dick, Shantu Amin, Dhimant Desai
Two structurally related protein kinase families, the Rho kinases (ROCK) and the myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK) are required for migration and invasion of cancer cells. We hypothesized that simultaneous targeting of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59dd31a2a72afd5feed29b4ca184163
https://europepmc.org/articles/PMC4182185/
https://europepmc.org/articles/PMC4182185/
